| Literature DB >> 28242671 |
Yong-Qiang Yang1, Yun-Xia Li1, Tao Song2, Yan-Xian Yang1, Wei Jiang1, An-Yun Zhang1, Xin-Yi Guo3, Bi-Hui Liu1, Yong-Xiang Wang1, Chang-Wei Lei1, Rong Xiang1, Hong-Ning Wang4.
Abstract
The mcr-1 gene was detected in 5.11% (58/1136) of Escherichia coli isolates of chicken origin from 13 provinces in China. A novel mcr-1 variant, named mcr-1.3, encoding an Ile-to-Val functional variant of MCR-1 was identified in a sequence type 155 (ST155) strain. An mcr-1.3-containing IncI2 plasmid, pHeN867 (60,757 bp), was identified. The transfer of pHeN867 led to a 32-fold increase in the MIC of colistin in the recipient, exhibiting an effect on colistin resistance that was similar to that of mcr-1.Entities:
Keywords: E. coli; colistin resistance; mcr-1.3; plasmid
Mesh:
Substances:
Year: 2017 PMID: 28242671 PMCID: PMC5404584 DOI: 10.1128/AAC.01204-16
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191