Literature DB >> 30038043

Coidentification of mcr-4.3 and blaNDM-1 in a Clinical Enterobacter cloacae Isolate from China.

Bhakti Chavda1, Jingnan Lv2, Mengyun Hou3, Kalyan D Chavda1, Barry N Kreiswirth1, Youjun Feng4, Liang Chen5, Fangyou Yu6,7.   

Abstract

We describe the first report of a clinical colistin-resistant ST84 Enterobacter cloacae isolate coharboring mcr-4.3 (previously named mcr-4.2) and blaNDM-1 from a patient in China. The blaNDM-1-harboring IncX3 plasmid and the novel mcr-4.3-harboring ColE plasmid were completely sequenced. Although this isolate showed a high level of resistance to colistin, mcr-4.3 plasmid transformation, gene subcloning, susceptibility testing, and lipid A matrix-assisted laser desorption ionization mass spectrometry analysis indicated that mcr-4.3 itself does not confer resistance to colistin.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  NDM-1; carbapenem resistant; colistin; mcr-4; plasmid

Mesh：

Substances：

Year:  2018        PMID： 30038043      PMCID： PMC6153785          DOI： 10.1128/AAC.00649-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

1.  Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes.

Authors:  Sally R Partridge; Vincenzo Di Pilato; Yohei Doi; Michael Feldgarden; Daniel H Haft; William Klimke; Samir Kumar-Singh; Jian-Hua Liu; Surbhi Malhotra-Kumar; Arjun Prasad; Gian Maria Rossolini; Stefan Schwarz; Jianzhong Shen; Timothy Walsh; Yang Wang; Basil Britto Xavier
Journal:  J Antimicrob Chemother       Date:  2018-10-01       Impact factor: 5.790

2.  Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016.

Authors:  Basil Britto Xavier; Christine Lammens; Rohit Ruhal; Samir Kumar-Singh; Patrick Butaye; Herman Goossens; Surbhi Malhotra-Kumar
Journal:  Euro Surveill       Date:  2016-07-07

3.  mcr-3 and mcr-4 Variants in Carbapenemase-Producing Clinical Enterobacteriaceae Do Not Confer Phenotypic Polymyxin Resistance.

Authors:  Jeanette W P Teo; Marimuthu Kalisvar; Indumathi Venkatachalam; Oon Tek Ng; Raymond T P Lin; Sophie Octavia
Journal:  J Clin Microbiol       Date:  2018-02-22       Impact factor: 5.948

4.  Colistin Resistance Gene mcr-1 and Its Variant in Escherichia coli Isolates from Chickens in China.

Authors:  Yong-Qiang Yang; Yun-Xia Li; Tao Song; Yan-Xian Yang; Wei Jiang; An-Yun Zhang; Xin-Yi Guo; Bi-Hui Liu; Yong-Xiang Wang; Chang-Wei Lei; Rong Xiang; Hong-Ning Wang
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

5.  Single-molecule sequencing to track plasmid diversity of hospital-associated carbapenemase-producing Enterobacteriaceae.

Authors:  Sean Conlan; Pamela J Thomas; Clayton Deming; Morgan Park; Anna F Lau; John P Dekker; Evan S Snitkin; Tyson A Clark; Khai Luong; Yi Song; Yu-Chih Tsai; Matthew Boitano; Jyoti Dayal; Shelise Y Brooks; Brian Schmidt; Alice C Young; James W Thomas; Gerard G Bouffard; Robert W Blakesley; James C Mullikin; Jonas Korlach; David K Henderson; Karen M Frank; Tara N Palmore; Julia A Segre
Journal:  Sci Transl Med       Date:  2014-09-17       Impact factor: 17.956

6.  Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance.

Authors:  Meredith S Wright; Yo Suzuki; Marcus B Jones; Steven H Marshall; Susan D Rudin; David van Duin; Keith Kaye; Michael R Jacobs; Robert A Bonomo; Mark D Adams
Journal:  Antimicrob Agents Chemother       Date:  2014-11-10       Impact factor: 5.191

7.  Complete nucleotide sequences of blaKPC-4- and blaKPC-5-harboring IncN and IncX plasmids from Klebsiella pneumoniae strains isolated in New Jersey.

Authors:  Liang Chen; Kalyan D Chavda; Henry S Fraimow; José R Mediavilla; Roberto G Melano; Michael R Jacobs; Robert A Bonomo; Barry N Kreiswirth
Journal:  Antimicrob Agents Chemother       Date:  2012-10-31       Impact factor: 5.191

8.  Co-occurrence of mcr-1, mcr-4 and mcr-5 genes in multidrug-resistant ST10 Enterotoxigenic and Shiga toxin-producing Escherichia coli in Spain (2006-2017).

Authors:  Vanesa García; Isidro García-Meniño; Azucena Mora; Saskia C Flament-Simon; Dafne Díaz-Jiménez; Jesús E Blanco; María Pilar Alonso; Jorge Blanco
Journal:  Int J Antimicrob Agents       Date:  2018-04-07       Impact factor: 5.283

9.  Identification of acquired antimicrobial resistance genes.

Authors:  Ea Zankari; Henrik Hasman; Salvatore Cosentino; Martin Vestergaard; Simon Rasmussen; Ole Lund; Frank M Aarestrup; Mette Voldby Larsen
Journal:  J Antimicrob Chemother       Date:  2012-07-10       Impact factor: 5.790

10.  An Evolutionarily Conserved Mechanism for Intrinsic and Transferable Polymyxin Resistance.

Authors:  Yongchang Xu; Wenhui Wei; Sheng Lei; Jingxia Lin; Swaminath Srinivas; Youjun Feng
Journal:  mBio       Date:  2018-04-10       Impact factor: 7.867
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  18 in total

1.  Identification of a Novel Plasmid Carrying mcr-4.3 in an Acinetobacter baumannii Strain in China.

Authors:  Furong Ma; Cong Shen; Yong Xia; Guo-Bao Tian; Xiaobin Zheng; Yan Liu; Hongtao Chen; Lanlan Zhong; Yingjian Liang; Kang Liao; Yongqiang Yang
Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

2.  MgrB Inactivation Is Responsible for Acquired Resistance to Colistin in Enterobacter hormaechei subsp. steigerwaltii.

Authors:  Amel Mhaya; Dominique Bégu; Slim Tounsi; Corinne Arpin
Journal:  Antimicrob Agents Chemother       Date:  2020-05-21       Impact factor: 5.191

3.  A novel plasmid-encoded mcr-4.3 gene in a colistin-resistant Acinetobacter baumannii clinical strain.

Authors:  Natacha Martins-Sorenson; Erik Snesrud; Danilo Elias Xavier; Luciana Camila Cacci; Anthony T Iavarone; Patrick McGann; Lee W Riley; Beatriz Meurer Moreira
Journal:  J Antimicrob Chemother       Date:  2020-01-01       Impact factor: 5.790

4.  Prevalence and Distribution of mcr Genotypes in a Large Retrospective Collection of Clinical Carbapenemase-Producing Enterobacterales, Singapore.

Authors:  Jeanette W P Teo; Sophie Octavia; Sai Rama Sridatta Prakki; Indumathi Venkatachalam; Kalisvar Marimuthu; Oon Tek Ng
Journal:  Antimicrob Agents Chemother       Date:  2022-08-29       Impact factor: 5.938

5.  Molecular mechanisms related to colistin resistance in Enterobacteriaceae.

Authors:  Zahra Aghapour; Pourya Gholizadeh; Khudaverdi Ganbarov; Abed Zahedi Bialvaei; Suhad Saad Mahmood; Asghar Tanomand; Mehdi Yousefi; Mohammad Asgharzadeh; Bahman Yousefi; Hossein Samadi Kafil
Journal:  Infect Drug Resist       Date:  2019-04-24       Impact factor: 4.003

6.  Definition of a Family of Nonmobile Colistin Resistance (NMCR-1) Determinants Suggests Aquatic Reservoirs for MCR-4.

Authors:  Huimin Zhang; Wenhui Wei; Man Huang; Zeeshan Umar; Youjun Feng
Journal:  Adv Sci (Weinh)       Date:  2019-04-03       Impact factor: 16.806

7.  First Report of bla VIM-4- and mcr-9-Coharboring Enterobacter Species Isolated from a Pediatric Patient.

Authors:  Kalyan D Chavda; Lars F Westblade; Michael J Satlin; Andrew C Hemmert; Mariana Castanheira; Stephen G Jenkins; Liang Chen; Barry N Kreiswirth
Journal:  mSphere       Date:  2019-09-11       Impact factor: 4.389

8.  Action and mechanism of the colistin resistance enzyme MCR-4.

Authors:  Huimin Zhang; Mengyun Hou; Yongchang Xu; Swaminath Srinivas; Man Huang; Lizhang Liu; Youjun Feng
Journal:  Commun Biol       Date:  2019-01-25

9.  Harnessing efficient multiplex PCR methods to detect the expanding Tet(X) family of tigecycline resistance genes.

Authors:  Kai Ji; Yongchang Xu; Jian Sun; Man Huang; Xu Jia; Chengjian Jiang; Youjun Feng
Journal:  Virulence       Date:  2020-12       Impact factor: 5.882

10.  Characterization of resistance mechanisms of Enterobacter cloacae Complex co-resistant to carbapenem and colistin.

Authors:  Shixing Liu; Renchi Fang; Ying Zhang; Lijiang Chen; Na Huang; Kaihang Yu; Cui Zhou; Jianming Cao; Tieli Zhou
Journal:  BMC Microbiol       Date:  2021-07-08       Impact factor: 3.605
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