Maryam Tayefi1, Mohammad Tajfard2, Sara Saffar3, Parichehr Hanachi4, Ali Reza Amirabadizadeh5, Habibollah Esmaeily6, Ali Taghipour6, Gordon A Ferns7, Mohsen Moohebati8, Majid Ghayour-Mobarhan9. 1. Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, 99199-91766 Mashhad, Iran ; Department of New Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Department of Health Education and Health Promotion, School of Health, Management and Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Neurogenic Inflammation Research Center, Department of New Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 4. Department of Biology, Biochemistry Unit, Alzahra University, Tehran, Iran. 5. Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran. 6. Department of Biostatistics and Epidemiology, School of Health, Management and Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 7. Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex BN1 9PH, UK. 8. Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Mouhebatim@mums.ac.ir. 9. Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, 99199-91766 Mashhad, Iran ; Department of New Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: ghayourm@mums.ac.ir.
Abstract
BACKGROUND AND AIMS: Coronary heart disease (CHD) is an important public health problem globally. Algorithms incorporating the assessment of clinical biomarkers together with several established traditional risk factors can help clinicians to predict CHD and support clinical decision making with respect to interventions. Decision tree (DT) is a data mining model for extracting hidden knowledge from large databases. We aimed to establish a predictive model for coronary heart disease using a decision tree algorithm. METHODS: Here we used a dataset of 2346 individuals including 1159 healthy participants and 1187 participant who had undergone coronary angiography (405 participants with negative angiography and 782 participants with positive angiography). We entered 10 variables of a total 12 variables into the DT algorithm (including age, sex, FBG, TG, hs-CRP, TC, HDL, LDL, SBP and DBP). RESULTS: Our model could identify the associated risk factors of CHD with sensitivity, specificity, accuracy of 96%, 87%, 94% and respectively. Serum hs-CRP levels was at top of the tree in our model, following by FBG, gender and age. CONCLUSION: Our model appears to be an accurate, specific and sensitive model for identifying the presence of CHD, but will require validation in prospective studies.
BACKGROUND AND AIMS: Coronary heart disease (CHD) is an important public health problem globally. Algorithms incorporating the assessment of clinical biomarkers together with several established traditional risk factors can help clinicians to predict CHD and support clinical decision making with respect to interventions. Decision tree (DT) is a data mining model for extracting hidden knowledge from large databases. We aimed to establish a predictive model for coronary heart disease using a decision tree algorithm. METHODS: Here we used a dataset of 2346 individuals including 1159 healthy participants and 1187 participant who had undergone coronary angiography (405 participants with negative angiography and 782 participants with positive angiography). We entered 10 variables of a total 12 variables into the DT algorithm (including age, sex, FBG, TG, hs-CRP, TC, HDL, LDL, SBP and DBP). RESULTS: Our model could identify the associated risk factors of CHD with sensitivity, specificity, accuracy of 96%, 87%, 94% and respectively. Serum hs-CRP levels was at top of the tree in our model, following by FBG, gender and age. CONCLUSION: Our model appears to be an accurate, specific and sensitive model for identifying the presence of CHD, but will require validation in prospective studies.