Jocelyne Bloch1, Stéphanie P Lacour2, Grégoire Courtine3. 1. Service de Neurochirurgie, Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. 2. Center for Neuroprosthetics, School of Engineering, Institutes of Microengineering and Bioengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. 3. Service de Neurochirurgie, Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland3Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, EPFL, Lausanne, Switzerland.
Abstract
IMPORTANCE: A growing number of neurologic treatments rely on neural implants capable of delivering electrical and chemical stimulation to targeted regions of the central nervous system for extended periods. OBJECTIVE: To assess the potential of a novel class of multimodal neural implants, termed electronic dura mater or e-dura, to fulfill this need. EVIDENCE REVIEW: Results from preclinical applications of e-dura implants and clinical evidence. FINDINGS: The silicone-based implant e-dura embeds interconnects, electrodes, and chemotrodes that are entirely stretchable. These unique mechanical properties allow e-dura to conform to the circumvolutions of the brain and spinal cord without damaging neural tissues or triggering foreign body reactions. CONCLUSIONS AND RELEVANCE: Although challenges lie ahead to reach clinical fruition, the unique mechanical properties and integrated modalities of e-dura provide future opportunities to treat or alleviate neurologic deficits.
IMPORTANCE: A growing number of neurologic treatments rely on neural implants capable of delivering electrical and chemical stimulation to targeted regions of the central nervous system for extended periods. OBJECTIVE: To assess the potential of a novel class of multimodal neural implants, termed electronic dura mater or e-dura, to fulfill this need. EVIDENCE REVIEW: Results from preclinical applications of e-dura implants and clinical evidence. FINDINGS: The silicone-based implant e-dura embeds interconnects, electrodes, and chemotrodes that are entirely stretchable. These unique mechanical properties allow e-dura to conform to the circumvolutions of the brain and spinal cord without damaging neural tissues or triggering foreign body reactions. CONCLUSIONS AND RELEVANCE: Although challenges lie ahead to reach clinical fruition, the unique mechanical properties and integrated modalities of e-dura provide future opportunities to treat or alleviate neurologic deficits.
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