Literature DB >> 28239677

The discontinuity theory of immunity.

Thomas Pradeu1, Eric Vivier2.   

Abstract

Some biological systems detect the rate of change in a stimulus rather than the stimulus itself only. We suggest that the immune system works in this way. According to the discontinuity theory of immunity, the immune system responds to sudden changes in antigenic stimulation and is rendered tolerant by slow or continuous stimulation. This basic principle, which is supported by recent data on immune checkpoints in viral infections, cancers, and allergies, can be seen as a unifying framework for diverse immune responses.

Entities:  

Year:  2016        PMID： 28239677      PMCID： PMC5321532          DOI： 10.1126/sciimmunol.aag0479

Source DB:  PubMed          Journal:  Sci Immunol        ISSN： 2470-9468


  30 in total

1.  Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses.

Authors:  Z Grossman; W E Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

2.  Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery.

Authors:  Shaobo Han; Ayuna Asoyan; Hannah Rabenstein; Naoko Nakano; Reinhard Obst
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-08       Impact factor: 11.205

Review 3.  Redefining chronic viral infection.

Authors:  Herbert W Virgin; E John Wherry; Rafi Ahmed
Journal:  Cell       Date:  2009-07-10       Impact factor: 41.582

Review 4.  Control of adaptive immunity by the innate immune system.

Authors:  Akiko Iwasaki; Ruslan Medzhitov
Journal:  Nat Immunol       Date:  2015-04       Impact factor: 25.606

Review 5.  Immune checkpoint blockade: a common denominator approach to cancer therapy.

Authors:  Suzanne L Topalian; Charles G Drake; Drew M Pardoll
Journal:  Cancer Cell       Date:  2015-04-06       Impact factor: 31.743

6.  Continuous T cell receptor signals maintain a functional regulatory T cell pool.

Authors:  J Christoph Vahl; Christoph Drees; Klaus Heger; Sylvia Heink; Julius C Fischer; Jelena Nedjic; Naganari Ohkura; Hiromasa Morikawa; Hendrik Poeck; Sonja Schallenberg; David Rieß; Marco Y Hein; Thorsten Buch; Bojan Polic; Anne Schönle; Robert Zeiser; Annette Schmitt-Gräff; Karsten Kretschmer; Ludger Klein; Thomas Korn; Shimon Sakaguchi; Marc Schmidt-Supprian
Journal:  Immunity       Date:  2014-11-06       Impact factor: 31.745

7.  The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection.

Authors:  Matthew M Staron; Simon M Gray; Heather D Marshall; Ian A Parish; Jonathan H Chen; Curtis J Perry; Guoliang Cui; Ming O Li; Susan M Kaech
Journal:  Immunity       Date:  2014-11-13       Impact factor: 31.745

8.  Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

Authors:  Seth L Masters; Vasiliki Lagou; Isabelle Jéru; Paul J Baker; Lien Van Eyck; David A Parry; Dylan Lawless; Dominic De Nardo; Josselyn E Garcia-Perez; Laura F Dagley; Caroline L Holley; James Dooley; Fiona Moghaddas; Emanuela Pasciuto; Pierre-Yves Jeandel; Raf Sciot; Dena Lyras; Andrew I Webb; Sandra E Nicholson; Lien De Somer; Erika van Nieuwenhove; Julia Ruuth-Praz; Bruno Copin; Emmanuelle Cochet; Myrna Medlej-Hashim; Andre Megarbane; Kate Schroder; Sinisa Savic; An Goris; Serge Amselem; Carine Wouters; Adrian Liston
Journal:  Sci Transl Med       Date:  2016-03-30       Impact factor: 17.956

9.  Response to self antigen imprints regulatory memory in tissues.

Authors:  Michael D Rosenblum; Iris K Gratz; Jonathan S Paw; Karen Lee; Ann Marshak-Rothstein; Abul K Abbas
Journal:  Nature       Date:  2011-11-27       Impact factor: 49.962

10.  Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment.

Authors:  Nathalie T Joncker; Nataliya Shifrin; Frédéric Delebecque; David H Raulet
Journal:  J Exp Med       Date:  2010-09-06       Impact factor: 14.307
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  10 in total

Review 1.  Allergy in an Evolutionary Framework.

Authors:  Alvaro Daschner; Juan González Fernández
Journal:  J Mol Evol       Date:  2019-06-07       Impact factor: 2.395

Review 2.  Polyvalent design in the cGAS-STING pathway.

Authors:  Zachary T Bennett; Suxin Li; Baran D Sumer; Jinming Gao
Journal:  Semin Immunol       Date:  2021-12-15       Impact factor: 11.130

3.  CD8+ T Lymphocyte and NK Cell Network: Circuitry in the Cytotoxic Domain of Immunity.

Authors:  Roman V Uzhachenko; Anil Shanker
Journal:  Front Immunol       Date:  2019-08-13       Impact factor: 7.561

Review 4.  Immunological Paradigms, Mechanisms, and Models: Conceptual Understanding Is a Prerequisite to Effective Modeling.

Authors:  Zvi Grossman
Journal:  Front Immunol       Date:  2019-11-05       Impact factor: 7.561

5.  The vaccinologist's "dirty little secret": a better understanding of structure-function relationships of viral immunogens might advance rational HIV vaccine design.

Authors:  Gregor P Greslehner
Journal:  Arch Virol       Date:  2021-02-19       Impact factor: 2.574

Review 6.  Immunotherapy with NK cells: recent developments in gene modification open up new avenues.

Authors:  Lisa Marie Reindl; Nawid Albinger; Tobias Bexte; Stephan Müller; Jessica Hartmann; Evelyn Ullrich
Journal:  Oncoimmunology       Date:  2020-09-02       Impact factor: 8.110

7.  Immune Tolerance vs. Immune Resistance: The Interaction Between Host and Pathogens in Infectious Diseases.

Authors:  Hafiz Ishfaq Ahmad; Abdul Jabbar; Nadia Mushtaq; Zainab Javed; Muhammad Umar Hayyat; Javaria Bashir; Iqra Naseeb; Zain Ul Abideen; Nisar Ahmad; Jinping Chen
Journal:  Front Vet Sci       Date:  2022-03-29

8.  Experimental Infection of the Biomphalaria glabrata Vector Snail by Schistosoma mansoni Parasites Drives Snail Microbiota Dysbiosis.

Authors:  Anaïs Portet; Eve Toulza; Ana Lokmer; Camille Huot; David Duval; Richard Galinier; Benjamin Gourbal
Journal:  Microorganisms       Date:  2021-05-18

Review 9.  Cancer as a disease of old age: changing mutational and microenvironmental landscapes.

Authors:  Ezio Laconi; Fabio Marongiu; James DeGregori
Journal:  Br J Cancer       Date:  2020-02-11       Impact factor: 7.640

10.  Speed and Location Both Matter: Antigen Stimulus Dynamics Controls CAR-T Cell Response.

Authors:  Can Liu; Timothy Qi; J Justin Milner; Yong Lu; Yanguang Cao
Journal:  Front Immunol       Date:  2021-10-08       Impact factor: 8.786
  10 in total

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