Literature DB >> 2823794

Induction of mRNA for phosphoenolpyruvate carboxykinase (GTP) by dexamethasone in cultured rat hepatocytes requires on-going protein synthesis.

V L Nebes1, S M Morris.   

Abstract

Dexamethasone is necessary and sufficient to induce mRNA for phosphoenolpyruvate carboxykinase (GTP) (PEPCK) by 19-fold in rat hepatocytes cultured in serum-free medium. However, the time required for maximum induction is 16 h. The slow induction suggested that glucocorticoids regulate the expression of an intermediate gene product(s) which is required for glucocorticoid stimulation of PEPCK-gene expression. Consistent with this notion was the finding that cycloheximide completely blocked the response to dexamethasone. In contrast, cycloheximide did not block the response to a cyclic AMP analogue.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2823794      PMCID： PMC1148264          DOI： 10.1042/bj2460237

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  31 in total

1.  Effects of cyclic adenosine monophosphate, dexamethasone and insulin on phosphoenolpyruvate carboxykinase synthesis in Reuber H-35 hepatoma cells.

Authors:  J M Gunn; S M Tilghman; R W Hanson; L Reshef; F J Ballard
Journal:  Biochemistry       Date:  1975-06-03       Impact factor: 3.162

2.  Induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase in the isolated perfused rat liver: interaction of dexamethasone and dibutyryl cyclic AMP.

Authors:  W Krone; W B Huttner; H J Seitz; W Tarnowski
Journal:  FEBS Lett       Date:  1975-03-15       Impact factor: 4.124

3.  Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. I. Multiple hormone regulatory elements and the effects of enhancers.

Authors:  A Wynshaw-Boris; J M Short; D S Loose; R W Hanson
Journal:  J Biol Chem       Date:  1986-07-25       Impact factor: 5.157

4.  Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

Authors:  J M Short; A Wynshaw-Boris; H P Short; R W Hanson
Journal:  J Biol Chem       Date:  1986-07-25       Impact factor: 5.157

5.  Glucocorticoid-regulated expression from the 5'-flanking region of the rat alpha 1-acid glycoprotein gene. Requirement for ongoing protein synthesis.

Authors:  E S Klein; R Reinke; P Feigelson; G M Ringold
Journal:  J Biol Chem       Date:  1987-01-15       Impact factor: 5.157

6.  Interaction of hydrocortisone and dibutyryl cyclic AMP in the induction of tyrosine amino-transferase and phosphoenolpyruvate carboxy-kinase in rat liver.

Authors:  W Krone; W B Huttner; H J Seitz; W Tarnowski
Journal:  FEBS Lett       Date:  1974-09-15       Impact factor: 4.124

7.  Alterations in translatable messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) in rat liver cytosol during deinduction.

Authors:  D Kioussis; L Reshef; H Cohen; S M Tilghman; P B Iynedjian; F J Ballard; R W Hanson
Journal:  J Biol Chem       Date:  1978-06-25       Impact factor: 5.157

8.  The effect of phorbol esters and diacylglycerol on expression of the phosphoenolpyruvate carboxykinase (GTP) gene in rat hepatoma H4IIE cells.

Authors:  D T Chu; D K Granner
Journal:  J Biol Chem       Date:  1986-12-25       Impact factor: 5.157

9.  Glucocorticoid-dependent expression of the albumin gene in adult rat hepatocytes.

Authors:  K Nawa; T Nakamura; A Kumatori; C Noda; A Ichihara
Journal:  J Biol Chem       Date:  1986-12-25       Impact factor: 5.157

10.  High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

Authors:  M N Berry; D S Friend
Journal:  J Cell Biol       Date:  1969-12       Impact factor: 10.539
View more
  5 in total

1.  Down-regulation of rat mitochondrial branched-chain 2-oxoacid dehydrogenase kinase gene expression by glucocorticoids.

Authors:  Y S Huang; D T Chuang
Journal:  Biochem J       Date:  1999-05-01       Impact factor: 3.857

Review 2.  Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver.

Authors:  F P Lemaigre; G G Rousseau
Journal:  Biochem J       Date:  1994-10-01       Impact factor: 3.857

3.  Cyclic AMP induces metallothionein gene expression in rat hepatocytes but not in rat kidney.

Authors:  V L Nebes; D DeFranco; S M Morris
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

4.  Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene.

Authors:  V M Christoffels; T Grange; K H Kaestner; T J Cole; G J Darlington; C M Croniger; W H Lamers
Journal:  Mol Cell Biol       Date:  1998-11       Impact factor: 4.272

5.  Protein-synthesis-dependent induction of annexin I by glucocorticoid.

Authors:  W T Wong; S C Frost; H S Nick
Journal:  Biochem J       Date:  1991-04-15       Impact factor: 3.857
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.