Literature DB >> 2849426

Cyclic AMP induces metallothionein gene expression in rat hepatocytes but not in rat kidney.

V L Nebes1, D DeFranco, S M Morris.   

Abstract

Cyclic AMP analogues induced expression of metallothionein-I (MT-I) mRNA in adult rat liver and in rat hepatocytes cultured in serum-free medium. This induction occurred via an increased rate of transcription of the MT-I gene. The effect of cyclic AMP analogues was tissue-specific since no induction of MT-I mRNA occurred in rat kidney. Induction of MT-I mRNA by a combination of cyclic AMP analogue and dexamethasone was additive in liver and cultured hepatocytes, indicating that induction occurred via independent regulatory pathways.

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Year:  1988        PMID： 2849426      PMCID： PMC1135289     

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  27 in total

1.  Hormonal regulation of liver metallothionein zinc: independent and synergistic action of glucagon and glucocorticoids.

Authors:  K R Etzel; R J Cousins
Journal:  Proc Soc Exp Biol Med       Date:  1981-06

2.  Differential expression of two neural cell-specific beta-tubulin mRNAs during rat brain development.

Authors:  J F Bond; G S Robinson; S R Farmer
Journal:  Mol Cell Biol       Date:  1984-07       Impact factor: 4.272

3.  Genomic sequencing.

Authors:  G M Church; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

4.  Growth of normal human glial cells in a defined medium containing platelet-derived growth factor.

Authors:  C H Heldin; A Wasteson; B Westermark
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

5.  Nucleotide triphosphate utilization by cardiac and skeletal muscle sarcoplasmic reticulum. Evidence for a hydrolysis cycle not coupled to intermediate acyl phosphate formation and calcium translocation.

Authors:  W B Van Winkle; C A Tate; R J Bick; M L Entman
Journal:  J Biol Chem       Date:  1981-03-10       Impact factor: 5.157

6.  Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids.

Authors:  L J Hager; R D Palmiter
Journal:  Nature       Date:  1981-05-28       Impact factor: 49.962

7.  Regulation of messenger ribonucleic acid levels for five urea cycle enzymes in cultured rat hepatocytes. Requirements for cyclic adenosine monophosphate, glucocorticoids, and ongoing protein synthesis.

Authors:  V L Nebes; S M Morris
Journal:  Mol Endocrinol       Date:  1988-05

8.  Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.

Authors:  D M Durnam; J S Hoffman; C J Quaife; E P Benditt; H Y Chen; R L Brinster; R D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

9.  Glucocorticoid regulation of metallothionein-I mRNA synthesis in cultured mouse cells.

Authors:  K E Mayo; R D Palmiter
Journal:  J Biol Chem       Date:  1981-03-25       Impact factor: 5.157

10.  Induction of cadmium-thionein in isolated rat liver cells.

Authors:  H A Hidalgo; V Koppa; S E Bryan
Journal:  Biochem J       Date:  1978-02-15       Impact factor: 3.857
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  4 in total

1.  Glucocorticoid and cAMP induction mechanisms are differentially affected by the p85gag-mos oncoprotein.

Authors:  B J Hamilton; D DeFranco
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

2.  Effect of stress, adrenalectomy and changes in glutathione metabolism on rat kidney metallothionein content: comparison with liver metallothionein.

Authors:  M Giralt; T Gasull; J Hernandez; A Garcia; J Hidalgo
Journal:  Biometals       Date:  1993       Impact factor: 2.949

3.  Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures.

Authors:  J J Schroeder; R J Cousins
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

4.  Activation of gene expression by metal-responsive signal transduction pathways.

Authors:  Timothy K Adams; Nurten Saydam; Florian Steiner; Walter Schaffner; Jonathan H Freedman
Journal:  Environ Health Perspect       Date:  2002-10       Impact factor: 9.031
  4 in total

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