Literature DB >> 28231547

Nonmonotonic responses to low doses of xenoestrogens: A review.

Zhixiang Xu1, Jun Liu1, Xinhao Wu1, Bin Huang2, Xuejun Pan1.   

Abstract

Xenoestrogens (XEs) mimic or block the synthesis, metabolism and transport of normal endogenous hormones, disturbing normal endocrine function. The available data on the nonmonotonic estrogenic effects of low doses of many XEs are reviewed, covering in vitro, in vivo and epidemiological studies. The observed nonmonotonic patterns of the dose-response curves are discussed, along with possible underlying mechanisms. This review is intended to provide guidance for harm predication and to suggest prevention measures.
Copyright © 2017 Elsevier Inc. All rights reserved.

Keywords:  Dose-response effects; Molecular mechanisms; Nonmonotonic responses; Toxicology; Xenoestrogens

Mesh：

Substances：

Year:  2017        PMID： 28231547     DOI： 10.1016/j.envres.2017.02.018

Source DB:  PubMed          Journal:  Environ Res        ISSN： 0013-9351            Impact factor:   6.498


  10 in total

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2.  The modulatory role of low concentrations of bisphenol A on tamoxifen-induced proliferation and apoptosis in breast cancer cells.

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4.  Identification of nonmonotonic concentration-responses in Tox21 high-throughput screening estrogen receptor assays.

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Journal:  Dev Reprod       Date:  2017-06-30

6.  Nonmonotonic Effects of Chronic Low-Dose Di(2-ethylhexyl) Phthalate on Gonadal Weight and Reproductive.

Authors:  Sunyeong Cha; Kayeon Jung; Min Young Lee; Yeon Jeong Hwang; Eunhyeok Yang; Sung-Ho Lee; Hyo-Il Jung; Yong-Pil Cheon
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7.  Transfer and Metabolism of the Xenoestrogen Zearalenone in Human Perfused Placenta.

Authors:  Benedikt Warth; Karin Preindl; Pius Manser; Peter Wick; Doris Marko; Tina Buerki-Thurnherr
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8.  Sex-dependent dysregulation of human neutrophil responses by bisphenol A.

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9.  Bisphenol A: Potential Factor of Miscarriage in Women in the Context of the Phenomenon of Neutrophil Extracellular Traps.

Authors:  Wioleta Justyna Omeljaniuk; Angelika Edyta Charkiewicz; Marzena Garley; Wioletta Ratajczak-Wrona; Jan Czerniecki; Ewa Jabłońska; Marzanna Cechowska-Pasko; Wojciech Miltyk
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2022-10-01       Impact factor: 3.831

10.  Effect of bisphenol A on human neutrophils immunophenotype.

Authors:  Wioletta Ratajczak-Wrona; Małgorzata Rusak; Karolina Nowak; Milena Dabrowska; Piotr Radziwon; Ewa Jablonska
Journal:  Sci Rep       Date:  2020-02-20       Impact factor: 4.379
  10 in total

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