Literature DB >> 28229975

Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family.

Aamir Ali1, Shweta Tyagi.   

Abstract

WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2- Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all the SET1 family of histone 3 lysine 4 histone methyltransferase (HMT) complexes. Collectively called the WRAD complex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novel non-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation and gene expression. In this review, we examine the diversity in emerging transcription-independent functions of WRAD.

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Year:  2017        PMID： 28229975     DOI： 10.1007/s12038-017-9666-9

Source DB:  PubMed          Journal:  J Biosci        ISSN： 0250-5991            Impact factor:   1.826


  37 in total

1.  A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.

Authors:  Stephen A Shinsky; Michael Hu; Valarie E Vought; Sarah B Ng; Michael J Bamshad; Jay Shendure; Michael S Cosgrove
Journal:  J Mol Biol       Date:  2014-03-27       Impact factor: 5.469

2.  PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

Authors:  Young-Wook Cho; Teresa Hong; Sunhwa Hong; Hong Guo; Hong Yu; Doyeob Kim; Tad Guszczynski; Gregory R Dressler; Terry D Copeland; Markus Kalkum; Kai Ge
Journal:  J Biol Chem       Date:  2007-05-11       Impact factor: 5.157

3.  WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.

Authors:  Ji-Joon Song; Robert E Kingston
Journal:  J Biol Chem       Date:  2008-10-07       Impact factor: 5.157

Review 4.  Epigenetic balance of gene expression by Polycomb and COMPASS families.

Authors:  Andrea Piunti; Ali Shilatifard
Journal:  Science       Date:  2016-06-03       Impact factor: 47.728

5.  Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4.

Authors:  Hans-Martin Herz; Man Mohan; Alexander S Garruss; Kaiwei Liang; Yoh-Hei Takahashi; Kristen Mickey; Olaf Voets; C Peter Verrijzer; Ali Shilatifard
Journal:  Genes Dev       Date:  2012-11-19       Impact factor: 11.361

6.  Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1.

Authors:  Zain Odho; Stacey M Southall; Jon R Wilson
Journal:  J Biol Chem       Date:  2010-08-17       Impact factor: 5.157

7.  Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.

Authors:  Anamika Patel; Venkatasubramanian Dharmarajan; Michael S Cosgrove
Journal:  J Biol Chem       Date:  2008-10-01       Impact factor: 5.157

8.  Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

Authors:  Rick van Nuland; Arne H Smits; Paschalina Pallaki; Pascal W T C Jansen; Michiel Vermeulen; H T Marc Timmers
Journal:  Mol Cell Biol       Date:  2013-03-18       Impact factor: 4.272

9.  A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking.

Authors:  Zhuojin Xu; Qiang Gong; Bin Xia; Benjamin Groves; Marc Zimmermann; Chris Mugler; Dezhi Mu; Brian Matsumoto; Matthew Seaman; Dzwokai Ma
Journal:  J Cell Biol       Date:  2009-08-03       Impact factor: 10.539

10.  Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.

Authors:  Guillermo Senisterra; Hong Wu; Abdellah Allali-Hassani; Gregory A Wasney; Dalia Barsyte-Lovejoy; Ludmila Dombrovski; Aiping Dong; Kong T Nguyen; David Smil; Yuri Bolshan; Taraneh Hajian; Hao He; Alma Seitova; Irene Chau; Fengling Li; Gennadiy Poda; Jean-François Couture; Peter J Brown; Rima Al-Awar; Matthieu Schapira; Cheryl H Arrowsmith; Masoud Vedadi
Journal:  Biochem J       Date:  2013-01-01       Impact factor: 3.857
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  12 in total

Review 1.  A novel de novo frameshift variant in SETD1B causes epilepsy.

Authors:  Kouhei Den; Mitsuhiro Kato; Tokito Yamaguchi; Satoko Miyatake; Atsushi Takata; Takeshi Mizuguchi; Noriko Miyake; Satomi Mitsuhashi; Naomichi Matsumoto
Journal:  J Hum Genet       Date:  2019-05-20       Impact factor: 3.172

Review 2.  COMPASS and SWI/SNF complexes in development and disease.

Authors:  Bercin K Cenik; Ali Shilatifard
Journal:  Nat Rev Genet       Date:  2020-09-21       Impact factor: 53.242

3.  Novel sub-cellular localizations and intra-molecular interactions may define new functions of Mixed Lineage Leukemia protein.

Authors:  Amit Mahendra Karole; Swathi Chodisetty; Aamir Ali; Nidhi Kumari; Shweta Tyagi
Journal:  Cell Cycle       Date:  2018-12-10       Impact factor: 4.534

4.  Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia.

Authors:  Leonid O Bryzgalov; Elena E Korbolina; Ilja I Brusentsov; Elena Y Leberfarb; Natalia P Bondar; Tatiana I Merkulova
Journal:  BMC Neurosci       Date:  2018-04-19       Impact factor: 3.288

5.  Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions.

Authors:  Ali Imran; Brandon S Moyer; Ashley J Canning; Dan Kalina; Thomas M Duncan; Kelsey J Moody; Aaron J Wolfe; Michael S Cosgrove; Liviu Movileanu
Journal:  Biochem J       Date:  2021-06-11       Impact factor: 3.766

6.  The COMPASS-like complex modulates fungal development and pathogenesis by regulating H3K4me3-mediated targeted gene expression in Magnaporthe oryzae.

Authors:  Sida Zhou; Xiuying Liu; Wanyu Sun; Mengyu Zhang; Yue Yin; Song Pan; Dan He; Mi Shen; Jun Yang; Qi Zheng; Weixiang Wang
Journal:  Mol Plant Pathol       Date:  2021-02-08       Impact factor: 5.663

7.  GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.

Authors:  Shan Wei; Songjian Lu; Lifan Liang; Xian Wang; Wan Li; Tingting Li; Luping Chen; Enguo Ju; Xinquan Zhang; Zhao Lai; Yufei Huang; Xinghua Lu; Shou-Jiang Gao
Journal:  mBio       Date:  2021-12-21       Impact factor: 7.867

8.  Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia.

Authors:  Timothy Newton; Rachel Allison; James R Edgar; Jennifer H Lumb; Catherine E Rodger; Paul T Manna; Tania Rizo; Zacharias Kohl; Anders O H Nygren; Larissa Arning; Rebecca Schüle; Christel Depienne; Lisa Goldberg; Christiane Frahm; Giovanni Stevanin; Alexandra Durr; Ludger Schöls; Beate Winner; Christian Beetz; Evan Reid
Journal:  Brain       Date:  2018-05-01       Impact factor: 13.501

9.  Comprehensive Profiling of Mammalian Tribbles Interactomes Implicates TRIB3 in Gene Repression.

Authors:  Miguel Hernández-Quiles; Rosalie Baak; Anouska Borgman; Suzanne den Haan; Paula Sobrevals Alcaraz; Robert van Es; Endre Kiss-Toth; Harmjan Vos; Eric Kalkhoven
Journal:  Cancers (Basel)       Date:  2021-12-16       Impact factor: 6.639

Review 10.  SET1/MLL family of proteins: functions beyond histone methylation.

Authors:  Jeyapal Sugeedha; Jyoti Gautam; Shweta Tyagi
Journal:  Epigenetics       Date:  2020-08-31       Impact factor: 4.528
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