Ana Carolina Amorim Pellicioli1, Felipe Paiva Fonseca2, Rodrigo Neves Silva2, Luiz Alcino Monteiro Gueiros3, Oslei Paes de Almeida2, Pablo Agustin Vargas2, Marcio Ajudarte Lopes2, Helder Antonio Rebelo Pontes4, Manoela Domingues Martins5, Vinícius Coelho Carrard6, Alan Roger Santos-Silva2. 1. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. Electronic address: anacarolinapellicioli@gmail.com. 2. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. 3. Oral Medicine Unit, Department of Clinic and Preventive Dentist, Federal University of Pernambuco, Recife, Brazil. 4. Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil. 5. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. 6. School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Abstract
OBJECTIVES: The aim of this study was to characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in the tissue biopsy samples of the tongue. STUDY DESIGN: A 12-year retrospective study on the files of 3 oral pathology centers yielded 28 SNPs. Hematoxylin and eosin-stained sections were used for histologic analysis, and immunohistochemical staining for S100 protein was performed to better characterize the neural structures. Slides were scanned and histomorphometric analysis carried out using ImageScope software. RESULTS: Twenty-one women (75%) and 6 men (21.4%) comprised the sample (mean age 46.4 and 49 years, respectively). Twenty cases (71.4%) were juxtaposed to the tongue epithelium and 16 cases (57.1%) were associated with lymphoid tissue. The mean area of the SNPs was 0.160 mm2, and the mean distance to the overlying epithelium was 0.312 mm. CONCLUSIONS: SNPs are normal neural structures located on the posterior border of the tongue that represent a non-neoplastic regional anatomic variation. In some cases, signs or symptoms may be present, and further investigation should be performed. Pathologists should be aware of this entity to avoid confusion with neural lesions.
OBJECTIVES: The aim of this study was to characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in the tissue biopsy samples of the tongue. STUDY DESIGN: A 12-year retrospective study on the files of 3 oral pathology centers yielded 28 SNPs. Hematoxylin and eosin-stained sections were used for histologic analysis, and immunohistochemical staining for S100 protein was performed to better characterize the neural structures. Slides were scanned and histomorphometric analysis carried out using ImageScope software. RESULTS: Twenty-one women (75%) and 6 men (21.4%) comprised the sample (mean age 46.4 and 49 years, respectively). Twenty cases (71.4%) were juxtaposed to the tongue epithelium and 16 cases (57.1%) were associated with lymphoid tissue. The mean area of the SNPs was 0.160 mm2, and the mean distance to the overlying epithelium was 0.312 mm. CONCLUSIONS: SNPs are normal neural structures located on the posterior border of the tongue that represent a non-neoplastic regional anatomic variation. In some cases, signs or symptoms may be present, and further investigation should be performed. Pathologists should be aware of this entity to avoid confusion with neural lesions.
Authors: John Lennon Silva Cunha; Ana Luiza Oliveira Corrêa Roza; Vitória Maria Sousa Cruz; Jaqueline Lemes Ribeiro; Israel Leal Cavalcante; Roberta Barroso Cavalcante; Ana Lia Anbinder; Aline Corrêa Abrahão; Bruno Augusto Benevenuto de Andrade; Mário José Romañach; Fábio Ramôa Pires; Alan Roger Dos Santos-Silva; Márcio Ajudarte Lopes; Pablo Agustin Vargas; Ciro Dantas Soares; Oslei Paes de Almeida Journal: Head Neck Pathol Date: 2021-06-29