Literature DB >> 2822484

The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria.

B Kholodenko1, V Zilinskiene, V Borutaite, L Ivanoviene, A Toleikis, A Praskevicius.   

Abstract

The regulative role of adenine nucleotide translocators (ANTs) in oxidative phosphorylation has been estimated by the titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the presence of a non-rate limiting creatine phosphokinase ADP-regenerating system. It has been established that the respiration rate is not controlled by ANTs in the two extreme states, state 3 and state 4. On the other hand, at an intermediate respiration rate (30-70% of the state 3 respiration, which roughly corresponds to that under physiological conditions) the ANT control coefficient had a value of 0.62-0.75. Thus, ANTs seem to play a key role in the regulation of oxidative phosphorylation.

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Year:  1987        PMID： 2822484     DOI： 10.1016/0014-5793(87)80298-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  19 in total

1.  Dominant and sensitive control of oxidative flux by the ATP-ADP carrier in human skeletal muscle mitochondria: Effect of lysine acetylation.

Authors:  W T Willis; D Miranda-Grandjean; J Hudgens; E A Willis; J Finlayson; E A De Filippis; R Zapata Bustos; P R Langlais; C Mielke; L J Mandarino
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2.  Control theory of metabolic channelling.

Authors:  B N Kholodenko; M Cascante; H V Westerhoff
Journal:  Mol Cell Biochem       Date:  1995-02-23       Impact factor: 3.396

Review 3.  Elusive control.

Authors:  H V Westerhoff; B N Kholodenko; M Cascante; K Van Dam
Journal:  J Bioenerg Biomembr       Date:  1995-10       Impact factor: 2.945

4.  Ca2+ stimulates both the respiratory and phosphorylation subsystems in rat heart mitochondria.

Authors:  V Mildaziene; R Baniene; Z Nauciene; A Marcinkeviciute; R Morkuniene; V Borutaite; B Kholodenko; G C Brown
Journal:  Biochem J       Date:  1996-11-15       Impact factor: 3.857

5.  Control of respiration in non-phosphorylating mitochondria is shared between the proton leak and the respiratory chain.

Authors:  M D Brand; R P Hafner; G C Brown
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

6.  Effect of calcium on the oxidative phosphorylation cascade in skeletal muscle mitochondria.

Authors:  Brian Glancy; Wayne T Willis; David J Chess; Robert S Balaban
Journal:  Biochemistry       Date:  2013-04-11       Impact factor: 3.162

7.  Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation.

Authors:  Clinton Mielke; Natalie Lefort; Carrie G McLean; Jeanine M Cordova; Paul R Langlais; Andrew J Bordner; Jerez A Te; S Banu Ozkan; Wayne T Willis; Lawrence J Mandarino
Journal:  Biochemistry       Date:  2014-06-09       Impact factor: 3.162

Review 8.  Control theory of metabolic channelling.

Authors:  B N Kholodenko; M Cascante; H V Westerhoff
Journal:  Mol Cell Biochem       Date:  1994 Apr-May       Impact factor: 3.396

9.  Influence of cerebral ischemia and post-ischemic reperfusion on mitochondrial oxidative phosphorylation.

Authors:  C K Kurup; K K Kumaroo; A J Dutka
Journal:  J Bioenerg Biomembr       Date:  1990-02       Impact factor: 2.945

10.  In brain mitochondria the branched-chain fatty acid phytanic acid impairs energy transduction and sensitizes for permeability transition.

Authors:  Peter Schönfeld; Stefan Kahlert; Georg Reiser
Journal:  Biochem J       Date:  2004-10-01       Impact factor: 3.857
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