Literature DB >> 28224730

The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures.

Alan Alper Sag1, Oguzhan Sal2, Yagmur Kilic2, Emine Meltem Onal2, Mehmet Kanbay3.   

Abstract

This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician-directed fashion. ©2017 Wiley Periodicals, Inc.

Entities:  

Keywords:  denervation; hypertension resistant to conventional therapy; hypertension, essential; radiology, interventional

Mesh：

Substances：

Year:  2017        PMID： 28224730      PMCID： PMC8031179          DOI： 10.1111/jch.12978

Source DB:  PubMed          Journal:  J Clin Hypertens (Greenwich)        ISSN： 1524-6175            Impact factor:   3.738


  30 in total

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3.  Foetal kidney maldevelopment in maternal use of angiotensin II type I receptor antagonists.

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Review 4.  The renal papilla and hypertension: an up-to-date review.

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5.  Identification and characterization of retinoic acid-responsive genes in mouse kidney development.

Authors:  Mami Takayama; Koichi Miyatake; Eisuke Nishida
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6.  Fixed-dose combination of zofenopril plus hydrochlorothiazide vs. irbesartan plus hydrochlorothiazide in hypertensive patients with established metabolic syndrome uncontrolled by previous monotherapy. The ZAMES study (Zofenopril in Advanced MEtabolic Syndrome).

Authors:  Claudio Napoli; Stefano Omboni; Claudio Borghi
Journal:  J Hypertens       Date:  2016-11       Impact factor: 4.844

Review 7.  Current Status of Renal Denervation in Hypertension.

Authors:  Alexander Briasoulis; George L Bakris
Journal:  Curr Cardiol Rep       Date:  2016-11       Impact factor: 2.931

Review 8.  Mitogen-activated protein kinases in innate immunity.

Authors:  J Simon C Arthur; Steven C Ley
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9.  Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension.

Authors:  Tuula Hannila-Handelberg; Kimmo Kontula; Ilkka Tikkanen; Tuula Tikkanen; Frej Fyhrquist; Karri Helin; Heidi Fodstad; Kirsi Piippo; Helena E Miettinen; Jarmo Virtamo; Tom Krusius; Seppo Sarna; Ivan Gautschi; Laurent Schild; Timo P Hiltunen
Journal:  BMC Med Genet       Date:  2005-01-20       Impact factor: 2.103

10.  Direct physical contact between intercalated cells in the distal convoluted tubule and the afferent arteriole in mouse kidneys.

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  5 in total

1.  Should we take renal denervation with a grain of salt?

Authors:  Baris Afsar; Alan A Sag; Mehmet Kanbay
Journal:  J Clin Hypertens (Greenwich)       Date:  2017-09-24       Impact factor: 3.738

2.  Renal artery intervention utilizing carbon dioxide angiography.

Authors:  Alan A Sag; Baris Afsar; Mehmet Kanbay
Journal:  Clin Kidney J       Date:  2017-10-09

3.  Renal denervation using carbon dioxide renal angiography in patients with uncontrolled hypertension and moderate to severe chronic kidney disease.

Authors:  Mohammed Awais Hameed; Jonathan S Freedman; Richard Watkin; Arul Ganeshan; Indranil Dasgupta
Journal:  Clin Kidney J       Date:  2017-08-29

Review 4.  The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures.

Authors:  Alan Alper Sag; Oguzhan Sal; Yagmur Kilic; Emine Meltem Onal; Mehmet Kanbay
Journal:  J Clin Hypertens (Greenwich)       Date:  2017-02-21       Impact factor: 3.738

5.  Revisiting angioplasty for renovascular hypertension.

Authors:  Alan A Sag; Mehmet Kanbay
Journal:  Clin Kidney J       Date:  2017-07-29
  5 in total

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