Onur Turan1, Barış Akinci2, Ahmet Omer Ikiz3, Oya Itil4, Ibrahim Oztura5, Emel Ada6, Bahri Akdeniz7, Serkan Yener2, Murat Kaya8, Arzu Gedik9, Abdurrahman Comlekci2. 1. Division of Chest Diseases, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey. 2. Division of Endocrinology and Metabolism, Dokuz Eylul University, Izmir, Turkey. 3. Division of Otolaryngology, Dokuz Eylul University, Izmir, Turkey. 4. Division of Chest Diseases, Dokuz Eylul University, Izmir, Turkey. 5. Division of Neurology, Dokuz Eylul University, Izmir, Turkey. 6. Division of Radiodiagnostics, Dokuz Eylul University, Izmir, Turkey. 7. Division of Cardiology, Dokuz Eylul University, Izmir, Turkey. 8. Division of Chest Diseases, Alanya Anatolia Hospital, Antalya, Turkey. 9. Division of Endocrinology and Metabolism, Ağrı State Hospital, Ağrı, Turkey.
Abstract
OBJECTIVE: Acromegaly is a multisystemic disorder caused by excessive secretion of growth hormone (GH). Sleep-disordered breathing (SDB) such as sleep apnea syndrome (SAS) may occur in acromegaly. The aim of study was to assess the presence of sleep disorders and evaluate the systemic complications on respiratory, cardiovascular, and upper airway systems in acromegalic patients. METHODS: The study group consisted of 30 acromegaly outpatients. GH and insulin-like growth factor 1 (IGF-1) measurements were obtained; body pletysmography, arterial blood gas analysis, tissue-doppler imaging, echocardiography, polysomnography, otorhinolaryngologic examination, and head-neck computed tomography were performed. RESULTS: Sixteen female (53.3%) and 14 male (46.7%) acromegalic patients had a mean age of 51.1 ± 13.2. GH was supressed in 19 patients (63.3%) when 11 had active acromegaly (36.7%). There were 17 patients with SAS (62.9%) (7: mild, 3:intermediate, 7:severe SAS) and average AHI was 16/h. Sixteen patients had predominantly obstructive SAS while one patient had predominantly central SAS. SAS was statistically more frequent in males than females (P = .015). The mean neck circumference was significantly longer in patients with SAS (P = .048). In SAS patients,the soft palate was elongated and thickened,which was statistically significant (P = .014 and P = .05).Vallecula-to-tongue distance was statistically longer in acromegalic patients with SAS (P = .007).There was a positive correlation between tonsil size,vallecula-to-tongue distance and AHI (r = 0.432, P = .045 and r = 0.512, P = .021, respectively). CONCLUSION: SDB seems to be common and clinically important in patients with acromegaly, particularly in men. The most frequent type of apnea in acromegalics is obstructive. Hormonal activity of acromegaly does not seem to have an effect on the development of SAS. Despite its high prevalence, SAS is frequently under-assessed in patients with acromegaly. Systemic complications and SDB should be researched in acromegalics.
OBJECTIVE:Acromegaly is a multisystemic disorder caused by excessive secretion of growth hormone (GH). Sleep-disordered breathing (SDB) such as sleep apnea syndrome (SAS) may occur in acromegaly. The aim of study was to assess the presence of sleep disorders and evaluate the systemic complications on respiratory, cardiovascular, and upper airway systems in acromegalicpatients. METHODS: The study group consisted of 30 acromegaly outpatients. GH and insulin-like growth factor 1 (IGF-1) measurements were obtained; body pletysmography, arterial blood gas analysis, tissue-doppler imaging, echocardiography, polysomnography, otorhinolaryngologic examination, and head-neck computed tomography were performed. RESULTS: Sixteen female (53.3%) and 14 male (46.7%) acromegalicpatients had a mean age of 51.1 ± 13.2. GH was supressed in 19 patients (63.3%) when 11 had active acromegaly (36.7%). There were 17 patients with SAS (62.9%) (7: mild, 3:intermediate, 7:severe SAS) and average AHI was 16/h. Sixteen patients had predominantly obstructive SAS while one patient had predominantly central SAS. SAS was statistically more frequent in males than females (P = .015). The mean neck circumference was significantly longer in patients with SAS (P = .048). In SAS patients,the soft palate was elongated and thickened,which was statistically significant (P = .014 and P = .05).Vallecula-to-tongue distance was statistically longer in acromegalicpatients with SAS (P = .007).There was a positive correlation between tonsil size,vallecula-to-tongue distance and AHI (r = 0.432, P = .045 and r = 0.512, P = .021, respectively). CONCLUSION: SDB seems to be common and clinically important in patients with acromegaly, particularly in men. The most frequent type of apnea in acromegalics is obstructive. Hormonal activity of acromegaly does not seem to have an effect on the development of SAS. Despite its high prevalence, SAS is frequently under-assessed in patients with acromegaly. Systemic complications and SDB should be researched in acromegalics.
Authors: Maria Rosaria Ambrosio; Irene Gagliardi; Sabrina Chiloiro; Ana Gonçalves Ferreira; Marta Bondanelli; Antonella Giampietro; Antonio Bianchi; Laura De Marinis; Maria Fleseriu; Maria Chiara Zatelli Journal: Endocrine Date: 2020-02-14 Impact factor: 3.633
Authors: Konstantina Vouzouneraki; Karl A Franklin; Maria Forsgren; Maria Wärn; Jenny Tiberg Persson; Helena Wik; Christina Dahlgren; Ann-Sofie Nilsson; Caroline Alkebro; Pia Burman; Eva-Marie Erfurth; Jeanette Wahlberg; Anna-Karin Åkerman; Charlotte Høybye; Oskar Ragnarsson; Britt Edén Engström; Per Dahlqvist Journal: Endocrine Date: 2018-07-31 Impact factor: 3.633
Authors: Thalijn L C Wolters; Sean H P P Roerink; Linda C A Drenthen; Jolanda H G M van Haren-Willems; Margaretha A E M Wagenmakers; Johannes W A Smit; Adrianus R M M Hermus; Romana T Netea-Maier Journal: J Clin Endocrinol Metab Date: 2020-01-01 Impact factor: 5.958