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Literature DB >> 28223390

Expression of the aac(6')-Ib-cr Gene in Class 1 Integrons.

Sophie Raherison^1,2,3, Thomas Jove^4,2,3, Margaux Gaschet^4,2,3, Emilie Pinault⁵, Aurore Tabesse^4,2,3, Carmen Torres⁶, Marie-Cécile Ploy^4,2,3.

Abstract

aac(6')-Ib-cr is a plasmid-mediated quinolone resistance gene embedded within a gene cassette, most often within an integron. It confers resistance to quinolones and aminoglycosides. We investigated the role of a 101-bp fragment frequently present upstream of the aac(6')-Ib-cr gene cassette and found that it contributes to the expression of aac(6')-Ib-cr and provides an alternative start codon, confirming the length of the AAC(6')-Ib-cr protein to 199 amino acids.

Entities: Chemical Species

Keywords: AAC(6′)-Ib-cr protein; antibiotic resistance; gene cassette expression

Mesh：

Substances：

Year: 2017 PMID： 28223390 PMCID： PMC5404527 DOI： 10.1128/AAC.02704-16

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

1. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

Authors: K J Livak; T D Schmittgen
Journal: Methods Date: 2001-12 Impact factor: 3.608

2. Intrahospitalary dissemination of Klebsiella pneumoniae carrying bla(DHA-1) and qnrB4 genes within a novel complex class 1 integron.

Authors: Mar Olga Pérez-Moreno; Vanesa Estepa; Yolanda Sáenz; María Cortell-Ortolá; Isabel Fort-Gallifa; Joaquim Ruiz; Carmen Torres
Journal: Diagn Microbiol Infect Dis Date: 2012-03-24 Impact factor: 2.803

3. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase.

Authors: Ari Robicsek; Jacob Strahilevitz; George A Jacoby; Mark Macielag; Darren Abbanat; Chi Hye Park; Karen Bush; David C Hooper
Journal: Nat Med Date: 2005-12-20 Impact factor: 53.440

4. Rapid amplification of complementary DNA ends for generation of full-length complementary DNAs: thermal RACE.

Authors: M A Frohman
Journal: Methods Enzymol Date: 1993 Impact factor: 1.600

5. Primary structure of an aminoglycoside 6'-N-acetyltransferase AAC(6')-4, fused in vivo with the signal peptide of the Tn3-encoded beta-lactamase.

Authors: G Tran van Nhieu; E Collatz
Journal: J Bacteriol Date: 1987-12 Impact factor: 3.490

6. Expression of the sulfonamide resistance gene from plasmid R46.

Authors: F Guerineau; L Brooks; P Mullineaux
Journal: Plasmid Date: 1990-01 Impact factor: 3.466

7. Characterization of two novel gene cassettes, dfrA27 and aadA16, in a non-O1, non-O139 Vibrio cholerae isolate from China.

Authors: J Sun; M Zhou; Q Wu; Y Ni
Journal: Clin Microbiol Infect Date: 2009-11-10 Impact factor: 8.067

Review 3. Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation.

Authors: Érica L Fonseca; Ana Carolina Vicente
Journal: Microorganisms Date: 2022-01-20

3 in total

Expression of the aac(6')-Ib-cr Gene in Class 1 Integrons.

1. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

2. Intrahospitalary dissemination of Klebsiella pneumoniae carrying bla(DHA-1) and qnrB4 genes within a novel complex class 1 integron.

3. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase.

4. Rapid amplification of complementary DNA ends for generation of full-length complementary DNAs: thermal RACE.

5. Primary structure of an aminoglycoside 6'-N-acetyltransferase AAC(6')-4, fused in vivo with the signal peptide of the Tn3-encoded beta-lactamase.

6. Expression of the sulfonamide resistance gene from plasmid R46.

7. Characterization of two novel gene cassettes, dfrA27 and aadA16, in a non-O1, non-O139 Vibrio cholerae isolate from China.

8. Expression of antibiotic resistance genes in the integrated cassettes of integrons.

Review 9. Gene cassettes and cassette arrays in mobile resistance integrons.

10. Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm.

1. Genetic and Biochemical Characterization of OXA-519, a Novel OXA-48-Like β-Lactamase.

2. Characterization of the novel In1059 harbouring VIM gene cassette.

Review 3. Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation.