Eugenia Eftimie Totu1, Aurelia Cristina Nechifor2, Gheorghe Nechifor3, Hassan Y Aboul-Enein4, Corina Marilena Cristache5. 1. Dept. of Analytical Chemistry and Environment Engineering, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu St., 1, Bucharest, Romania. Electronic address: eugenia_totu@yahoo.com. 2. Dept. of Analytical Chemistry and Environment Engineering, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu St., 1, Bucharest, Romania. Electronic address: nechiforus@yahoo.com. 3. Dept. of Analytical Chemistry and Environment Engineering, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu St., 1, Bucharest, Romania. Electronic address: doru.nechifor@yahoo.com. 4. Pharmaceutical and Medicinal Chemistry Department, Pharamceutical and Drug Industries Research Division, National Research Centre, Dokki, Giza 12622, Egypt,. Electronic address: haboulenein@yahoo.com. 5. Faculty of Midwifery and Medical Assisting, "Carol Davila" University of Medicine and Pharmacy, 8, Blvd Eroilor Sanitari, 050474, Bucharest, Romania,. Electronic address: corinacristache@gmail.com.
Abstract
OBJECTIVES: The aim of this study was to obtain a Poly(methylmethacrylate) (PMMA)-TiO2 nanocomposite material with improved antibacterial characteristics, suitable for manufacturing 3D printed dental prosthesis. METHODS: 0.2, 0.4, 0.6, 1, 2.5 by weight% of TiO2 nanoparticles have been added to the commercially available stereolithographic PMMA material and the obtained nanocomposites have been analyzed using FTIR, SEM and also tested for antimicrobial efficacy against bacterial cultures from Candida species (C. scotti). RESULTS: SEM images and EDX results highlighted the presence of TiO2 in PMMA nanocomposites. The elemental composition (EDX) also showed the presence of other fillers included in stereolithographic PMMA solution. FTIR analysis clearly revealed changes in polymeric matrix structure when adding TiO2 nanoparticles. Sample containing 0.4, 1 and 2.5wt% TiO2 nanoparticles inhibited the growth of Candida scotti strain in standard conditions according to the toxicity control method (DHA). Increasing quantity of nano-titania has resulted in particles fooling, forming new aggregates instead of the homogenous dispersion of nanoparticles with modified viscosity characteristics and expected lower mechanical parameters. CONCLUSIONS: Significant improvements in polymer characteristics and nice dispersion of the TiO2 nanoparticles have been noticed for 0.4wt%, therefore it was used for stereolitographic complete denture prototyping. CLINICAL SIGNIFICANCE: Incorporation of TiO2 nanoparticles in PMMA polymer matrix was proved to have antibacterial effects, specifically on Candida species. The newly obtained 0.4% nanocomposite was successfully used with stereolitographic technique for complete denture manufacturing. However, mechanical and biocompatibility tests need to be performed in order to extend the clinical usage.
OBJECTIVES: The aim of this study was to obtain a Poly(methylmethacrylate) (PMMA)-TiO2 nanocomposite material with improved antibacterial characteristics, suitable for manufacturing 3D printed dental prosthesis. METHODS: 0.2, 0.4, 0.6, 1, 2.5 by weight% of TiO2 nanoparticles have been added to the commercially available stereolithographic PMMA material and the obtained nanocomposites have been analyzed using FTIR, SEM and also tested for antimicrobial efficacy against bacterial cultures from Candida species (C. scotti). RESULTS: SEM images and EDX results highlighted the presence of TiO2 in PMMA nanocomposites. The elemental composition (EDX) also showed the presence of other fillers included in stereolithographic PMMA solution. FTIR analysis clearly revealed changes in polymeric matrix structure when adding TiO2 nanoparticles. Sample containing 0.4, 1 and 2.5wt% TiO2 nanoparticles inhibited the growth of Candida scotti strain in standard conditions according to the toxicity control method (DHA). Increasing quantity of nano-titania has resulted in particles fooling, forming new aggregates instead of the homogenous dispersion of nanoparticles with modified viscosity characteristics and expected lower mechanical parameters. CONCLUSIONS: Significant improvements in polymer characteristics and nice dispersion of the TiO2 nanoparticles have been noticed for 0.4wt%, therefore it was used for stereolitographic complete denture prototyping. CLINICAL SIGNIFICANCE: Incorporation of TiO2 nanoparticles in PMMA polymer matrix was proved to have antibacterial effects, specifically on Candida species. The newly obtained 0.4% nanocomposite was successfully used with stereolitographic technique for complete denture manufacturing. However, mechanical and biocompatibility tests need to be performed in order to extend the clinical usage.
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