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Literature DB >> 28218911

Expanding the product portfolio of fungal type I fatty acid synthases.

Zhiwei Zhu^1,2,3, Yongjin J Zhou^1,3, Anastasia Krivoruchko^1,3,4, Martin Grininger⁵, Zongbao K Zhao^2,6, Jens Nielsen^1,3,4,7,8.

Abstract

Fungal type I fatty acid synthases (FASs) are mega-enzymes with two separated, identical compartments, in which the acyl carrier protein (ACP) domains shuttle substrates to catalytically active sites embedded in the chamber wall. We devised synthetic FASs by integrating heterologous enzymes into the reaction chambers and demonstrated their capability to convert acyl-ACP or acyl-CoA from canonical fatty acid biosynthesis to short/medium-chain fatty acids and methyl ketones.

Entities: Chemical

Mesh：

Substances：

Year: 2017 PMID： 28218911 DOI： 10.1038/nchembio.2301

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

24 in total

1. Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.

Authors: Simon Jenni; Marc Leibundgut; Daniel Boehringer; Christian Frick; Bohdan Mikolásek; Nenad Ban
Journal: Science Date: 2007-04-13 Impact factor: 47.728

2. The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together.

Authors: Ivan B Lomakin; Yong Xiong; Thomas A Steitz
Journal: Cell Date: 2007-04-20 Impact factor: 41.582

3. Engineering fatty acid synthases for directed polyketide production.

Authors: Jan Gajewski; Floris Buelens; Sascha Serdjukow; Melanie Janßen; Niña Cortina; Helmut Grubmüller; Martin Grininger
Journal: Nat Chem Biol Date: 2017-02-20 Impact factor: 15.040

4. Enzymatic functions of wild tomato methylketone synthases 1 and 2.

Authors: Geng Yu; Thuong T H Nguyen; Yongxia Guo; Ines Schauvinhold; Michele E Auldridge; Nazmul Bhuiyan; Imri Ben-Israel; Yoko Iijima; Eyal Fridman; Joseph P Noel; Eran Pichersky
Journal: Plant Physiol Date: 2010-07-06 Impact factor: 8.340

5. Disrupted short chain specific β-oxidation and improved synthase expression increase synthesis of short chain fatty acids in Saccharomyces cerevisiae.

Authors: Christopher Leber; Jin Wook Choi; Brian Polson; Nancy A Da Silva
Journal: Biotechnol Bioeng Date: 2015-10-18 Impact factor: 4.530

6. Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS.

Authors: Manuel Fischer; Daniel Rhinow; Zhiwei Zhu; Deryck J Mills; Zongbao K Zhao; Janet Vonck; Martin Grininger
Journal: Protein Sci Date: 2015-04-02 Impact factor: 6.725

7. Engineering of Saccharomyces cerevisiae for the synthesis of short chain fatty acids.

Authors: Christopher Leber; Nancy A Da Silva
Journal: Biotechnol Bioeng Date: 2013-09-03 Impact factor: 4.530

8. Fast and accurate preparation fatty acid methyl esters by microwave-assisted derivatization in the yeast Saccharomyces cerevisiae.

Authors: Sakda Khoomrung; Pramote Chumnanpuen; Suwanee Jansa-ard; Intawat Nookaew; Jens Nielsen
Journal: Appl Microbiol Biotechnol Date: 2012-05-09 Impact factor: 4.813

9. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways.

Authors: Zengyi Shao; Hua Zhao; Huimin Zhao
Journal: Nucleic Acids Res Date: 2008-12-12 Impact factor: 16.971

10. Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories.

Authors: Yongjin J Zhou; Nicolaas A Buijs; Zhiwei Zhu; Jiufu Qin; Verena Siewers; Jens Nielsen
Journal: Nat Commun Date: 2016-05-25 Impact factor: 14.919

34 in total

1. Engineering fatty acid synthases for directed polyketide production.

Authors: Jan Gajewski; Floris Buelens; Sascha Serdjukow; Melanie Janßen; Niña Cortina; Helmut Grubmüller; Martin Grininger
Journal: Nat Chem Biol Date: 2017-02-20 Impact factor: 15.040

2. Fatty acid synthases: Re-engineering biofactories.

Authors: Timm Maier
Journal: Nat Chem Biol Date: 2017-03-22 Impact factor: 15.040

Review 3. The architectures of iterative type I PKS and FAS.

Authors: Dominik A Herbst; Craig A Townsend; Timm Maier
Journal: Nat Prod Rep Date: 2018-10-17 Impact factor: 13.423

4. QnAs with Jens Nielsen.

Authors: Tinsley H Davis
Journal: Proc Natl Acad Sci U S A Date: 2020-03-23 Impact factor: 11.205

Review 5. Microbial synthesis of medium-chain chemicals from renewables.

Authors: Stephen Sarria; Nicholas S Kruyer; Pamela Peralta-Yahya
Journal: Nat Biotechnol Date: 2017-12-08 Impact factor: 54.908

6. Metabolic engineering of β-oxidation to leverage thioesterases for production of 2-heptanone, 2-nonanone and 2-undecanone.

Authors: Qiang Yan; Trevor R Simmons; William T Cordell; Néstor J Hernández Lozada; Christian J Breckner; Xuanqi Chen; Michael A Jindra; Brian F Pfleger
Journal: Metab Eng Date: 2020-05-29 Impact factor: 9.783

Review 7. Microbial production of advanced biofuels.

Authors: Jay Keasling; Hector Garcia Martin; Taek Soon Lee; Aindrila Mukhopadhyay; Steven W Singer; Eric Sundstrom
Journal: Nat Rev Microbiol Date: 2021-06-25 Impact factor: 60.633

8. Chimeric Fatty Acyl-Acyl Carrier Protein Thioesterases Provide Mechanistic Insight into Enzyme Specificity and Expression.

Authors: Marika Ziesack; Nathan Rollins; Aashna Shah; Brendon Dusel; Gordon Webster; Pamela A Silver; Jeffrey C Way
Journal: Appl Environ Microbiol Date: 2018-05-01 Impact factor: 4.792

9. Engineering carboxylic acid reductase for selective synthesis of medium-chain fatty alcohols in yeast.

Authors: Yating Hu; Zhiwei Zhu; David Gradischnig; Margit Winkler; Jens Nielsen; Verena Siewers
Journal: Proc Natl Acad Sci U S A Date: 2020-09-01 Impact factor: 11.205

10. Structural insight into Pichia pastoris fatty acid synthase.

Authors: Joseph S Snowden; Jehad Alzahrani; Lee Sherry; Martin Stacey; David J Rowlands; Neil A Ranson; Nicola J Stonehouse
Journal: Sci Rep Date: 2021-05-07 Impact factor: 4.379