Literature DB >> 28218000

Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa.

Ping-Chung Kuo1, Hsin-Yi Hung1, Chi-Wei Nian2, Tsong-Long Hwang3, Ju-Chien Cheng4, Daih-Huang Kuo5, E-Jian Lee6, Shih-Huang Tai6, Tian-Shung Wu1,5.   

Abstract

Fifty compounds were isolated from the fruits of Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1-8), three new lignans (9-11), a new iridoid (12), and a new triterpenoid (13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro. The results showed that several compounds displayed significant inhibition of fMLP/CB-induced superoxide anion generation and elastase release, with IC50 values ranging from 0.6 ± 0.1 to 8.6 ± 0.8 μg/mL and from 0.8 ± 0.3 to 7.3 ± 1.1 μg/mL, respectively.

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Year:  2017        PMID： 28218000     DOI： 10.1021/acs.jnatprod.6b01141

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

1.  Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity.

Authors:  Shih-Huang Tai; Ping-Chung Kuo; Ching-Che Hung; Ying-Hsuan Lin; Tsong-Long Hwang; Sio Hong Lam; Daih-Huang Kuo; Jin-Bin Wu; Hsin-Yi Hung; Tian-Shung Wu
Journal:  RSC Adv       Date:  2019-10-23       Impact factor: 4.036

Review 2.  Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics.

Authors:  Zhanglu Dong; Xianyuan Lu; Xueli Tong; Yaqian Dong; Lan Tang; Menghua Liu
Journal:  Molecules       Date:  2017-09-04       Impact factor: 4.411

3.  Forsythoside A Modulates Zymosan-Induced Peritonitis in Mice.

Authors:  Xiao-Tian Zhang; Yue Ding; Ping Kang; Xin-Yu Zhang; Tong Zhang
Journal:  Molecules       Date:  2018-03-06       Impact factor: 4.411

4.  Self-Microemulsifying Drug Delivery System of Phillygenin: Formulation Development, Characterization and Pharmacokinetic Evaluation.

Authors:  Lingzhi Wang; Wenrui Yan; Yurun Tian; Huanhuan Xue; Jiankai Tang; Liwei Zhang
Journal:  Pharmaceutics       Date:  2020-02-03       Impact factor: 6.321

Review 5.  Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes.

Authors:  Emmanuelle Lautié; Olivier Russo; Pierre Ducrot; Jean A Boutin
Journal:  Front Pharmacol       Date:  2020-04-07       Impact factor: 5.810

6.  Tissue-Specific Accumulation and Isomerization of Valuable Phenylethanoid Glycosides from Plantago and Forsythia Plants.

Authors:  Moritz Zürn; Gergő Tóth; Tim Ausbüttel; Zoltán Mucsi; Kata Horváti; Szilvia Bősze; Magdolna Sütöri-Diószegi; Bernadett Pályi; Zoltán Kis; Béla Noszál; Imre Boldizsár
Journal:  Int J Mol Sci       Date:  2021-04-09       Impact factor: 5.923

Review 7.  Extraction Techniques and Analytical Methods for Isolation and Characterization of Lignans.

Authors:  Andrzej Patyra; Małgorzata Kołtun-Jasion; Oktawia Jakubiak; Anna Karolina Kiss
Journal:  Plants (Basel)       Date:  2022-09-05

8.  Phytochemical Investigation and Anti-Inflammatory Activity of the Leaves of Machilus japonica var. kusanoi.

Authors:  Shiou-Ling Li; Ho-Cheng Wu; Tsong-Long Hwang; Chu-Hung Lin; Shuen-Shin Yang; Hsun-Shuo Chang
Journal:  Molecules       Date:  2020-09-10       Impact factor: 4.411

9.  Meso-Dihydroguaiaretic Acid Ameliorates Acute Respiratory Distress Syndrome through Inhibiting Neutrophilic Inflammation and Scavenging Free Radical.

Authors:  Yen-Tung Lee; Yu-Li Chen; Yi-Hsuan Wu; Ih-Sheng Chen; Hsun-Shuo Chang; Yi-Hsuan Wang; Shih-Hsin Chang; Yi-Hsiu Wu; Ting-I Kao; Huang-Ping Yu; Tsong-Long Hwang
Journal:  Antioxidants (Basel)       Date:  2022-01-06
  9 in total

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