Literature DB >> 28217800

X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.

H Yang1, D R Du Bois1, J W Ziller1, J S Nowick1.   

Abstract

The X-ray crystallographic structure of a truncated teixobactin analogue reveals hydrogen-bonding and hydrophobic interactions and a cavity that binds a chloride anion. Minimum inhibitory concentration (MIC) assays against Gram-positive bacteria correlate the observed structure with antibiotic activity.

Entities:  

Mesh：

Substances：

Year:  2017        PMID： 28217800      PMCID： PMC5381722          DOI： 10.1039/c7cc00783c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

1.  The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics.

Authors:  Shang-Te D Hsu; Eefjan Breukink; Eugene Tischenko; Mandy A G Lutters; Ben de Kruijff; Robert Kaptein; Alexandre M J J Bonvin; Nico A J van Nuland
Journal:  Nat Struct Mol Biol       Date:  2004-09-12       Impact factor: 15.369

2.  A new antibiotic kills pathogens without detectable resistance.

Authors:  Losee L Ling; Tanja Schneider; Aaron J Peoples; Amy L Spoering; Ina Engels; Brian P Conlon; Anna Mueller; Till F Schäberle; Dallas E Hughes; Slava Epstein; Michael Jones; Linos Lazarides; Victoria A Steadman; Douglas R Cohen; Cintia R Felix; K Ashley Fetterman; William P Millett; Anthony G Nitti; Ashley M Zullo; Chao Chen; Kim Lewis
Journal:  Nature       Date:  2015-01-07       Impact factor: 49.962

3.  Efficient total syntheses and biological activities of two teixobactin analogues.

Authors:  Anish Parmar; Abhishek Iyer; Charlotte S Vincent; Dorien Van Lysebetten; Stephen H Prior; Annemieke Madder; Edward J Taylor; Ishwar Singh
Journal:  Chem Commun (Camb)       Date:  2016-04-26       Impact factor: 6.222

4.  Elucidation of the Teixobactin Pharmacophore.

Authors:  Hyunjun Yang; Kevin H Chen; James S Nowick
Journal:  ACS Chem Biol       Date:  2016-06-03       Impact factor: 5.100

5.  A Highly Stereoselective and Scalable Synthesis of L-allo-Enduracididine.

Authors:  William Craig; Janet Chen; David Richardson; Rondel Thorpe; Yu Yuan
Journal:  Org Lett       Date:  2015-09-10       Impact factor: 6.005

6.  Dual Targeting of Cell Wall Precursors by Teixobactin Leads to Cell Lysis.

Authors:  Tomoyuki Homma; Austin Nuxoll; Autumn Brown Gandt; Patrick Ebner; Ina Engels; Tanja Schneider; Friedrich Götz; Kim Lewis; Brian P Conlon
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

7.  Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activities.

Authors:  Anish Parmar; Stephen H Prior; Abhishek Iyer; Charlotte S Vincent; Dorien Van Lysebetten; Eefjan Breukink; Annemieke Madder; Edward J Taylor; Ishwar Singh
Journal:  Chem Commun (Camb)       Date:  2017-02-07       Impact factor: 6.222

8.  Total Synthesis of Teixobactin.

Authors:  Andrew M Giltrap; Luke J Dowman; Gayathri Nagalingam; Jessica L Ochoa; Roger G Linington; Warwick J Britton; Richard J Payne
Journal:  Org Lett       Date:  2016-05-18       Impact factor: 6.005

9.  Synthesis and Biological Evaluation of a Teixobactin Analogue.

Authors:  Yahya E Jad; Gerardo A Acosta; Tricia Naicker; Melissa Ramtahal; Ayman El-Faham; Thavendran Govender; Hendrik G Kruger; Beatriz G de la Torre; Fernando Albericio
Journal:  Org Lett       Date:  2015-12-10       Impact factor: 6.005

10.  Total synthesis of teixobactin.

Authors:  Kang Jin; Iek Hou Sam; Kathy Hiu Laam Po; Du'an Lin; Ebrahim H Ghazvini Zadeh; Sheng Chen; Yu Yuan; Xuechen Li
Journal:  Nat Commun       Date:  2016-08-03       Impact factor: 14.919
View more
  13 in total

1.  Linearized teixobactin is inactive and after sequence enhancement, kills methicillin-resistant Staphylococcus aureus via a different mechanism.

Authors:  Qianhui Wu; Biswajit Mishra; Guangshun Wang
Journal:  Pept Sci (Hoboken)       Date:  2022-04-25

2.  Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin.

Authors:  Hyunjun Yang; Arthur V Pishenko; Xingyue Li; James S Nowick
Journal:  J Org Chem       Date:  2019-12-09       Impact factor: 4.354

3.  X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly.

Authors:  Hyunjun Yang; Michał Wierzbicki; Derek R Du Bois; James S Nowick
Journal:  J Am Chem Soc       Date:  2018-10-12       Impact factor: 15.419

4.  Binding Modes of Teixobactin to Lipid II: Molecular Dynamics Study.

Authors:  Yang Liu; Yaxin Liu; Mary B Chan-Park; Yuguang Mu
Journal:  Sci Rep       Date:  2017-12-08       Impact factor: 4.379

Review 5.  In silico approach in reveal traditional medicine plants pharmacological material basis.

Authors:  Fan Yi; Li Li; Li-Jia Xu; Hong Meng; Yin-Mao Dong; Hai-Bo Liu; Pei-Gen Xiao
Journal:  Chin Med       Date:  2018-06-19       Impact factor: 5.455

6.  Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding.

Authors:  Anish Parmar; Abhishek Iyer; Stephen H Prior; Daniel G Lloyd; Eunice Tze Leng Goh; Charlotte S Vincent; Timea Palmai-Pallag; Csanad Z Bachrati; Eefjan Breukink; Annemieke Madder; Rajamani Lakshminarayanan; Edward J Taylor; Ishwar Singh
Journal:  Chem Sci       Date:  2017-10-05       Impact factor: 9.825

7.  Structural studies suggest aggregation as one of the modes of action for teixobactin.

Authors:  Carl Öster; Grzegorz P Walkowiak; Dallas E Hughes; Amy L Spoering; Aaron J Peoples; Anita C Catherwood; Julie A Tod; Adrian J Lloyd; Torsten Herrmann; Kim Lewis; Christopher G Dowson; Józef R Lewandowski
Journal:  Chem Sci       Date:  2018-09-20       Impact factor: 9.825

8.  Probing key elements of teixobactin-lipid II interactions in membranes.

Authors:  Po-Chao Wen; Juan M Vanegas; Susan B Rempe; Emad Tajkhorshid
Journal:  Chem Sci       Date:  2018-07-20       Impact factor: 9.825

9.  Investigation of the N-Terminus Amino Function of Arg10-Teixobactin.

Authors:  Shimaa A H Abdel Monaim; Sikabwe Noki; Estelle J Ramchuran; Ayman El-Faham; Fernando Albericio; Beatriz G de la Torre
Journal:  Molecules       Date:  2017-09-28       Impact factor: 4.411

10.  In Vitro Antibacterial Activity of Teixobactin Derivatives on Clinically Relevant Bacterial Isolates.

Authors:  Estelle J Ramchuran; Anou M Somboro; Shimaa A H Abdel Monaim; Daniel G Amoako; Raveen Parboosing; Hezekiel M Kumalo; Nikhil Agrawal; Fernando Albericio; Beatriz G de La Torre; Linda A Bester
Journal:  Front Microbiol       Date:  2018-07-11       Impact factor: 5.640
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.