| Literature DB >> 26654835 |
Yahya E Jad, Gerardo A Acosta1,2, Tricia Naicker, Melissa Ramtahal, Ayman El-Faham3,4, Thavendran Govender, Hendrik G Kruger, Beatriz G de la Torre, Fernando Albericio1,2,4,5.
Abstract
The first synthesis and biological activity of a teixobactin analogue is reported. Substitution of the unusual L-allo-enduracididine residue by the naturally occurring L-arginine was achieved, and the analogue gave an activity trend similar to that of teixobactin (against Gram-postive bacteria) and meropenem, which was approved by the FDA in 1996. The synthetic route used allows for the synthesis of the natural product as well as the development of a program of medicinal chemistry.Entities:
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Year: 2015 PMID： 26654835 DOI： 10.1021/acs.orglett.5b03176
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005