Kota Tsutsumimoto1, Hyuma Makizako2, Takehiko Doi2, Ryo Hotta2, Sho Nakakubo2, Keitaro Makino2, Hiroyuki Shimada3, Takao Suzuki4. 1. Section for Health Promotion,Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; Japan Society for the Promotion of Science, Tokyo, Japan. Electronic address: kota.tsutsu@gmail.com. 2. Section for Health Promotion,Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan. 3. Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan. 4. National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; Institute for Gerontology, J.F. Oberlin University Graduate School, Tokyo, Japan.
Abstract
OBJECTIVE: Although subjective memory complaints (SMCs) are considered a risk factor for incident dementia in older people, the effect might differ based on cognitive function. The aim of the present study was to investigate whether the effect of SMCs on the incidence of dementia in older people differed based on cognitive function. DESIGN: A 24-month follow-up cohort study. SETTING: Japanese community. PARTICIPANTS: Prospective, longitudinal data for incident dementia were collected for 3,672 participants (mean age: 71.7 years; 46.5% men) for up to 24 months. MEASUREMENTS: Baseline measurements included covariates for incident dementia, SMCs, and cognitive function. Associations between SMCs, cognitive impairment, and incident dementia were examined using Cox proportional hazards models. RESULTS: Incidences of dementia in the cognitively intact without SMC, cognitively intact with SMC, cognitive impairment without SMC, and cognitive impairment with SMC groups were 0.3%, 1.8%, 3.4%, and 4.8%, respectively. In the cognitively intact participants, SMCs were associated with a significantly higher risk of dementia (hazard ratio [HR]: 4.95, 95% confidence interval [CI]: 1.52-16.11, p = 0.008). Incident dementia with cognitive impairment was not significantly different based on SMC presence (p = 0.527). Participants with cognitive impairment in multiple domains had a significantly higher risk of incident dementia (HR: 2.07, 95% CI: 1.01-4.24, p = 0.046) CONCLUSION: SMCs were related with dementia in cognitively intact older people, but not in those with cognitive impairment.Multiple domains of cognitive impairment were associated with a higher risk of incident dementia.
OBJECTIVE: Although subjective memory complaints (SMCs) are considered a risk factor for incident dementia in older people, the effect might differ based on cognitive function. The aim of the present study was to investigate whether the effect of SMCs on the incidence of dementia in older people differed based on cognitive function. DESIGN: A 24-month follow-up cohort study. SETTING: Japanese community. PARTICIPANTS: Prospective, longitudinal data for incident dementia were collected for 3,672 participants (mean age: 71.7 years; 46.5% men) for up to 24 months. MEASUREMENTS: Baseline measurements included covariates for incident dementia, SMCs, and cognitive function. Associations between SMCs, cognitive impairment, and incident dementia were examined using Cox proportional hazards models. RESULTS: Incidences of dementia in the cognitively intact without SMC, cognitively intact with SMC, cognitive impairment without SMC, and cognitive impairment with SMC groups were 0.3%, 1.8%, 3.4%, and 4.8%, respectively. In the cognitively intact participants, SMCs were associated with a significantly higher risk of dementia (hazard ratio [HR]: 4.95, 95% confidence interval [CI]: 1.52-16.11, p = 0.008). Incident dementia with cognitive impairment was not significantly different based on SMC presence (p = 0.527). Participants with cognitive impairment in multiple domains had a significantly higher risk of incident dementia (HR: 2.07, 95% CI: 1.01-4.24, p = 0.046) CONCLUSION: SMCs were related with dementia in cognitively intact older people, but not in those with cognitive impairment.Multiple domains of cognitive impairment were associated with a higher risk of incident dementia.
Authors: David P Sheppard; Matthew W Gallagher; Erin E Morgan; Angulique Y Outlaw; Sylvie Naar; Steven Paul Woods Journal: J Int Neuropsychol Soc Date: 2021-05-06 Impact factor: 3.114
Authors: Lauren Zajac; Bang-Bon Koo; Yorghos Tripodis; Asim Mian; Eric Steinberg; Jesse Mez; Michael L Alosco; Anna Cervantes-Arslanian; Robert Stern; Ronald Killiany Journal: Cereb Cortex Commun Date: 2020-05-28
Authors: Anya Topiwala; Sana Suri; Charlotte Allan; Enikő Zsoldos; Nicola Filippini; Claire E Sexton; Abda Mahmood; Archana Singh-Manoux; Clare E Mackay; Mika Kivimäki; Klaus P Ebmeier Journal: Am J Geriatr Psychiatry Date: 2020-07-07 Impact factor: 4.105