| Literature DB >> 28215223 |
Abstract
The balance of CD4+CD25+FOXP3+ regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imbalance of them is related to many inflammatory diseases in both human and mice. Here we discuss about the plasticity of Tregs and Th17 cells, and the related human diseases resulted from the imbalance of them. Further, we will focus on the mechanisms regulating the plasticity between Tregs and Th17 cells and the potential therapeutic strategies by targeting regulators of the expression and activity of FOXP3 and RORγt or regulators of Treg/Th17 balance in autoimmune diseases, allergy, infection, and cancer.Entities:
Keywords: Disease; FOXP3; Plasticity; RORγt; Th17; Tregs
Mesh：
Substances：
Year: 2016 PMID： 28215223 DOI： 10.1016/bs.apcsb.2016.10.002
Source DB: PubMed Journal: Adv Protein Chem Struct Biol ISSN： 1876-1623 Impact factor: 3.507