Literature DB >> 33302787

Regulation of mRNA stability by RBPs and noncoding RNAs contributing to the pathogenicity of Th17 cells.

Yiwei Zhang1,2, Zhiyuan Wei2, Hui Dong1, Jian Zhou1, Jizhao Yuan1, Bing Ni3, Yuzhang Wu1, Chao Han1, Yi Tian1.   

Abstract

Th17 cells remain one of the most important subsets of T cells in numerous autoimmune and chronic inflammatory diseases. Posttranscriptional regulation (PTR), especially mRNA stability, has recently emerged as an important mechanism that controls the fate of Th17 cells. This review summarizes the current knowledge on RNA-binding proteins (RBPs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) that induce mRNA stability changes and their roles in mediating the differentiation, proliferation, function, and migration of Th17 cells. In addition, we summarize the role of RNA modifications and nonsense-mediated mRNA decay (NMD) in Th17 cells. Ongoing research will help to identify practical applications for the regulation of mRNA stability and provide potential targets to prevent and treat Th17-related autoimmune diseases.

Entities:  

Keywords:  Th17; decay; lncRNAs; mRNA stability; miRNAs; nmd; pathogenicity; rbps; rna modifications

Mesh：

Substances：

Year:  2020        PMID： 33302787      PMCID： PMC8078524          DOI： 10.1080/15476286.2020.1862567

Source DB:  PubMed          Journal:  RNA Biol        ISSN： 1547-6286            Impact factor:   4.652


  129 in total

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Authors:  Xiang-Ping Yang; Kamran Ghoreschi; Scott M Steward-Tharp; Jaime Rodriguez-Canales; Jinfang Zhu; John R Grainger; Kiyoshi Hirahara; Hong-Wei Sun; Lai Wei; Golnaz Vahedi; Yuka Kanno; John J O'Shea; Arian Laurence
Journal:  Nat Immunol       Date:  2011-01-30       Impact factor: 25.606

2.  Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.

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Journal:  Nature       Date:  2006-04-30       Impact factor: 49.962

3.  Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs.

Authors:  X C Fan; J A Steitz
Journal:  EMBO J       Date:  1998-06-15       Impact factor: 11.598

Review 4.  Crosstalk in NF-κB signaling pathways.

Authors:  Andrea Oeckinghaus; Matthew S Hayden; Sankar Ghosh
Journal:  Nat Immunol       Date:  2011-07-19       Impact factor: 25.606

5.  Cyclin A message stability varies with the cell cycle.

Authors:  A Maity; W G McKenna; R J Muschel
Journal:  Cell Growth Differ       Date:  1997-03

6.  Posttranscriptional regulation of cyclin B messenger RNA expression in the regenerating rat liver.

Authors:  J H Trembley; B T Kren; C J Steer
Journal:  Cell Growth Differ       Date:  1994-01

7.  A validated regulatory network for Th17 cell specification.

Authors:  Maria Ciofani; Aviv Madar; Carolina Galan; Maclean Sellars; Kieran Mace; Florencia Pauli; Ashish Agarwal; Wendy Huang; Christopher N Parkhurst; Michael Muratet; Kim M Newberry; Sarah Meadows; Alex Greenfield; Yi Yang; Preti Jain; Francis K Kirigin; Carmen Birchmeier; Erwin F Wagner; Kenneth M Murphy; Richard M Myers; Richard Bonneau; Dan R Littman
Journal:  Cell       Date:  2012-09-25       Impact factor: 41.582

8.  The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses.

Authors:  Marlies Meisel; Natascha Hermann-Kleiter; Reinhard Hinterleitner; Thomas Gruber; Katarzyna Wachowicz; Christa Pfeifhofer-Obermair; Friedrich Fresser; Michael Leitges; Cristiana Soldani; Antonella Viola; Sandra Kaminski; Gottfried Baier
Journal:  Immunity       Date:  2013-01-03       Impact factor: 31.745

9.  Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.

Authors:  Keiji Hirota; Hiroyuki Yoshitomi; Motomu Hashimoto; Shinji Maeda; Shin Teradaira; Naoshi Sugimoto; Tomoyuki Yamaguchi; Takashi Nomura; Hiromu Ito; Takashi Nakamura; Noriko Sakaguchi; Shimon Sakaguchi
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Review 10.  Therapeutic strategies for the costimulatory molecule OX40 in T-cell-mediated immunity.

Authors:  Yu Fu; Qing Lin; Zhirong Zhang; Ling Zhang
Journal:  Acta Pharm Sin B       Date:  2019-09-03       Impact factor: 11.413
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  2 in total

Review 1.  Modulation of miRISC-Mediated Gene Silencing in Eukaryotes.

Authors:  Courtney F Jungers; Sergej Djuranovic
Journal:  Front Mol Biosci       Date:  2022-02-14

Review 2.  ADP-Ribosylation Post-Translational Modification: An Overview with a Focus on RNA Biology and New Pharmacological Perspectives.

Authors:  Giuseppe Manco; Giuseppina Lacerra; Elena Porzio; Giuliana Catara
Journal:  Biomolecules       Date:  2022-03-13
  2 in total

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