Literature DB >> 2821431

The contribution of behavioural studies to the neuropharmacology of anxiety.

S E File1.   

Abstract

This article reviews animal tests of anxiety and charts the contribution of behavioural studies to the neuropharmacology of anxiety. In particular it has been possible to distinguish several sites of action for anxiogenic drugs. Whilst great progress has been made to knowledge of the functioning of the GABA-benzodiazepine receptor complex, there has been little advance in the understanding of the other neurochemical pathways concerned with mediating changes in anxiety. The claim to have a drug that is a non-sedative anxiolytic should be based on firm behavioural evidence. The extent to which this has been realised for the existing candidates is reviewed.

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Year:  1987        PMID： 2821431     DOI： 10.1016/0028-3908(87)90065-7

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  21 in total

1.  Dendritic morphology of amygdala and hippocampal neurons in more and less predator stress responsive rats and more and less spontaneously anxious handled controls.

Authors:  Robert Adamec; Mark Hebert; Jacqueline Blundell; Ronald F Mervis
Journal:  Behav Brain Res       Date:  2011-09-12       Impact factor: 3.332

2.  Discriminative stimulus effects of the alpha 2-adrenoceptor antagonist idazoxan.

Authors:  D J Sanger
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

3.  The alpha 2-adrenoceptor antagonists idazoxan and yohimbine increase rates of DRL responding in rats.

Authors:  D J Sanger
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

4.  Screening antidepressants in the chick separation-stress paradigm.

Authors:  Matthew W Feltenstein; Kenneth J Sufka
Journal:  Psychopharmacology (Berl)       Date:  2005-10-15       Impact factor: 4.530

5.  The antidepressant drug phenelzine produces antianxiety effects in the plus-maze and increases in rat brain GABA.

Authors:  T Paslawski; D Treit; G B Baker; M George; R T Coutts
Journal:  Psychopharmacology (Berl)       Date:  1996-09       Impact factor: 4.530

6.  Opposite effects of agonist and inverse agonist ligands of benzodiazepine receptor on self-defensive and submissive postures in the rat.

Authors:  B Piret; A Depaulis; M Vergnes
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

7.  Differences in fear motivated behaviors among inbred mouse strains.

Authors:  R Trullas; P Skolnick
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

8.  Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat.

Authors:  S E File; A L Johnston
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

9.  A re-evaluation of the role of alpha 2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat.

Authors:  W S Redfern; A Williams
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

10.  Idazoxan increases rough-and-tumble play, activity and exploration in juvenile rats.

Authors:  S M Siviy; D M Atrens; J A Menendez
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530
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