Christina Magnussen1, Francisco M Ojeda2, Nargiz Rzayeva2, Tanja Zeller2, Christoph R Sinning2, Norbert Pfeiffer3, Manfred Beutel4, Maria Blettner5, Karl J Lackner6, Stefan Blankenberg2, Thomas Münzel7, Klaus F Rabe8, Philipp S Wild9, Renate B Schnabel2. 1. Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany. Electronic address: c.magnussen@uke.de. 2. Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany. 3. Department of Ophthalmology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany. 4. Department of Psychosomatic Medicine and Psychotherapy, Johannes Gutenberg-University Mainz, Mainz, Germany. 5. Institute of Medical Biometry, Epidemiology and Informatics (IMBEI), Johannes Gutenberg-University Mainz, Mainz, Germany. 6. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. 7. Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. 8. LungenClinic Großhansdorf and Christian Albrechts Universität Kiel, Airway Research Center North within the German Center for Lung Research (DZL), Germany. 9. Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Center for Translational Vascular Biology (CTVB), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Abstract
BACKGROUND: Lung function has previously been related to increased mortality. Whether pulmonary impairment is associated with an increased mortality independent of cardiac dysfunction remains unclear. METHODS: In 15010 individuals from the general population (age range 35-74years, 51% men) in the Gutenberg Health Study we performed spirometry and transthoracic echocardiography. N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and high-sensitive troponin I (hsTnI) were measured in all individuals. 1819 individuals with pulmonary diseases were excluded from further analysis. RESULTS: The median for forced expiratory volume in 1s (FEV1) was 94.2% and for forced vital capacity (FVC) 94.2% as a percentage of their predicted values. The median FEV1/FVC ratio was 79.1%. In 13191 subjects, 335 deaths were verified from death certificate over a median follow-up of 5.5years. Multivariable-adjusted Cox regression analyses for common cardiovascular risk factors and heart failure revealed that an increase of one standard deviation (SD) of percent predicted (%pred.) FEV1 was associated with a 22% risk reduction (hazard ratio [HR] per SD 0.78 [95% confidence interval (CI): 0.70, 0.86]). The association remained statistically significant after additional adjustment for diastolic dysfunction, Nt-proBNP or hsTnI. Comparable results were seen for %pred. FVC. After adjustment, no association of FEV1/FVC ratio with mortality could be shown. No significant interaction by heart failure was observed. CONCLUSIONS: The lung function parameters FEV1 and FVC, but not FEV1/FVC ratio, were related to all-cause mortality in individuals from the general population independent of cardiac function.
BACKGROUND: Lung function has previously been related to increased mortality. Whether pulmonary impairment is associated with an increased mortality independent of cardiac dysfunction remains unclear. METHODS: In 15010 individuals from the general population (age range 35-74years, 51% men) in the Gutenberg Health Study we performed spirometry and transthoracic echocardiography. N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and high-sensitive troponin I (hsTnI) were measured in all individuals. 1819 individuals with pulmonary diseases were excluded from further analysis. RESULTS: The median for forced expiratory volume in 1s (FEV1) was 94.2% and for forced vital capacity (FVC) 94.2% as a percentage of their predicted values. The median FEV1/FVC ratio was 79.1%. In 13191 subjects, 335 deaths were verified from death certificate over a median follow-up of 5.5years. Multivariable-adjusted Cox regression analyses for common cardiovascular risk factors and heart failure revealed that an increase of one standard deviation (SD) of percent predicted (%pred.) FEV1 was associated with a 22% risk reduction (hazard ratio [HR] per SD 0.78 [95% confidence interval (CI): 0.70, 0.86]). The association remained statistically significant after additional adjustment for diastolic dysfunction, Nt-proBNP or hsTnI. Comparable results were seen for %pred. FVC. After adjustment, no association of FEV1/FVC ratio with mortality could be shown. No significant interaction by heart failure was observed. CONCLUSIONS: The lung function parameters FEV1 and FVC, but not FEV1/FVC ratio, were related to all-cause mortality in individuals from the general population independent of cardiac function.
Authors: Charles Antwi-Boasiako; Michael M Asare; Ibrahim Baba; Alfred Doku; Kevin Adutwum-Ofosu; Charles Hayfron-Benjamin; Chamila P Asare; Robert Aryee; Gifty Boatemaah Dankwah; John Ahenkorah Journal: Am J Blood Res Date: 2021-04-15
Authors: Andrew J Collaro; Anne B Chang; Julie M Marchant; Mark D Chatfield; Annette Dent; Kwun M Fong; Margaret S McElrea Journal: Lung Date: 2022-10-22 Impact factor: 3.777
Authors: Obianuju B Ozoh; Joy N Eze; Olufunke O Adeyeye; Ojiebun Eromosele; Sandra K Dede; Chizalu I Ndukwu; Richard Van Zyl-Smit Journal: Niger Med J Date: 2020-08-04