Literature DB >> 28213183

A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure.

Kara Gross Margolis1.   

Abstract

Many disease conditions considered CNS-predominant harbor significant intestinal comorbidities. Serotonin (5-HT) and the serotonin reuptake transporter (SERT) have increasingly been shown to play important roles in both brain and intestinal development and long-term function. 5-HT and SERT may thus modulate critical functions in the development and perpetuation of brain-gut axis disease. We discuss the potential roles of 5-HT and SERT in the brain and intestinal manifestations of autism spectrum disorders and developmental antidepressant exposure. The potential therapeutic value of 5-HT4 modulation in the subsequent treatment of these conditions is also addressed.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  5-HT(4) receptor; Antidepressants; Autism spectrum disorders; Brain-gut axis; Selective serotonin reuptake inhibitors; Serotonin; Serotonin reuptake transporter

Mesh：

Substances：

Year:  2017        PMID： 28213183      PMCID： PMC5555828          DOI： 10.1016/j.jchemneu.2017.02.001

Source DB:  PubMed          Journal:  J Chem Neuroanat        ISSN： 0891-0618            Impact factor:   3.052


  62 in total

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2.  Distinct effects of perinatal exposure to fluoxetine or methylmercury on parvalbumin and perineuronal nets, the markers of critical periods in brain development.

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Review 3.  Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets.

Authors:  Gary M Mawe; Jill M Hoffman
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2013-06-25       Impact factor: 46.802

Review 4.  Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders.

Authors:  Preeti Jaiswal; Kochupurackal P Mohanakumar; Usha Rajamma
Journal:  Neurosci Biobehav Rev       Date:  2015-05-27       Impact factor: 8.989

5.  Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.

Authors:  Jill M Hoffman; Karl Tyler; Sarah J MacEachern; Onesmo B Balemba; Anthony C Johnson; Elice M Brooks; Hong Zhao; Greg M Swain; Peter L Moses; James J Galligan; Keith A Sharkey; Beverley Greenwood-Van Meerveld; Gary M Mawe
Journal:  Gastroenterology       Date:  2012-01-04       Impact factor: 22.682

6.  Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception.

Authors:  J X Chen; H Pan; T P Rothman; P R Wade; M D Gershon
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Review 7.  Safety of Selective Serotonin Reuptake Inhibitors in Pregnancy: A Review of Current Evidence.

Authors:  Sura Alwan; Jan M Friedman; Christina Chambers
Journal:  CNS Drugs       Date:  2016-06       Impact factor: 5.749

8.  Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder.

Authors:  Sarah Marler; Bradley J Ferguson; Evon Batey Lee; Brittany Peters; Kent C Williams; Erin McDonnell; Eric A Macklin; Pat Levitt; Catherine Hagan Gillespie; George M Anderson; Kara Gross Margolis; David Q Beversdorf; Jeremy Veenstra-VanderWeele
Journal:  J Autism Dev Disord       Date:  2016-03

Review 9.  Brain-gut-microbiota axis: challenges for translation in psychiatry.

Authors:  John R Kelly; Gerard Clarke; John F Cryan; Timothy G Dinan
Journal:  Ann Epidemiol       Date:  2016-03-08       Impact factor: 3.797

Review 10.  Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome.

Authors:  Rachel D Moloney; Anthony C Johnson; Siobhain M O'Mahony; Timothy G Dinan; Beverley Greenwood-Van Meerveld; John F Cryan
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  8 in total

1.  Impact of Auditory Integration Therapy (AIT) on the Plasma Levels of Human Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Autism Spectrum Disorder.

Authors:  Laila Al-Ayadhi; Afaf El-Ansary; Geir Bjørklund; Salvatore Chirumbolo; Gehan Ahmed Mostafa
Journal:  J Mol Neurosci       Date:  2019-05-09       Impact factor: 3.444

Review 2.  Novel aspects of enteric serotonergic signaling in health and brain-gut disease.

Authors:  Andrew Del Colle; Narek Israelyan; Kara Gross Margolis
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2019-11-04       Impact factor: 4.052

Review 3.  The gut, its microbiome, and the brain: connections and communications.

Authors:  Michael D Gershon; Kara Gross Margolis
Journal:  J Clin Invest       Date:  2021-09-15       Impact factor: 19.456

Review 4.  Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation.

Authors:  Sabah Haq; Jensine A Grondin; Waliul I Khan
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Review 5.  The Microbiota-Gut-Brain Axis: From Motility to Mood.

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Journal:  Gastroenterology       Date:  2021-01-22       Impact factor: 22.682

Review 6.  Prenatal Stress and Maternal Immune Dysregulation in Autism Spectrum Disorders: Potential Points for Intervention.

Authors:  David Q Beversdorf; Hanna E Stevens; Kara Gross Margolis; Judy Van de Water
Journal:  Curr Pharm Des       Date:  2019       Impact factor: 3.310

7.  Brain Network for Exploring the Change of Brain Neurotransmitter 5-Hydroxytryptamine of Autism Children by Resting-State EEG.

Authors:  Jun Shao; Fan Zhang; Chuanzhi Chen; Ye Wang; Qiang Wang; Jie Zhou
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8.  p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.

Authors:  Matthew J Robson; Meagan A Quinlan; Kara Gross Margolis; Paula A Gajewski-Kurdziel; Jeremy Veenstra-VanderWeele; Michael D Gershon; D Martin Watterson; Randy D Blakely
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-08       Impact factor: 11.205
  8 in total

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