| Literature DB >> 26527110 |
Sarah Marler1, Bradley J Ferguson2, Evon Batey Lee3, Brittany Peters4, Kent C Williams5, Erin McDonnell6, Eric A Macklin7, Pat Levitt8,9, Catherine Hagan Gillespie10, George M Anderson11, Kara Gross Margolis12, David Q Beversdorf13, Jeremy Veenstra-VanderWeele14,15,16.
Abstract
Elevated whole blood serotonin levels are observed in more than 25% of children with autism spectrum disorder (ASD). Co-occurring gastrointestinal (GI) symptoms are also common in ASD but have not previously been examined in relationship with hyperserotonemia, despite the synthesis of serotonin in the gut. In 82 children and adolescents with ASD, we observed a correlation between a quantitative measure of lower GI symptoms and whole blood serotonin levels. No significant association was seen between functional constipation diagnosis and serotonin levels in the hyperserotonemia range, suggesting that this correlation is not driven by a single subgroup. More specific assessment of gut function, including the microbiome, will be necessary to evaluate the contribution of gut physiology to serotonin levels in ASD.Entities:
Keywords: 5-HT; Autism Treatment Network; Gastrointestinal (GI); IL-6; Medical comorbidities; Serotonin
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Year: 2016 PMID： 26527110 PMCID： PMC4852703 DOI： 10.1007/s10803-015-2646-8
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257