Jean P Ferreira1, Cristina D Sartor2, Ângela M O Leal3, Isabel C N Sacco2, Tatiana O Sato1, Ivana L Ribeiro1, Alice S Soares1, Jonathan E Cunha1, Tania F Salvini4. 1. Laboratory of Skeletal Muscle Plasticity, Department of Physical Therapy, Federal University of São Carlos, SP, Brazil. 2. Physical Therapy, Speech and Occupational Therapy Department, School of Medicine, University of São Paulo, São Paulo, SP, Brazil. 3. Department of Medicine, Federal University of São Carlos, São Carlos, SP, Brazil. 4. Laboratory of Skeletal Muscle Plasticity, Department of Physical Therapy, Federal University of São Carlos, SP, Brazil. Electronic address: tania@ufscar.br.
Abstract
BACKGROUND: Skeletal muscle strength is poorly described and understood in diabetic participants with diabetic peripheral neuropathy. This study aimed to investigate the extensor and flexor torque of the knee and ankle during concentric, eccentric, and isometric contractions in men with diabetes mellitus type 2 with and without diabetic peripheral neuropathy. METHODS: Three groups of adult men (n=92), similar in age, body mass index, and testosterone levels, were analyzed: 33 non-diabetic controls, 31 with type 2 diabetes mellitus, and 28 with diabetic peripheral neuropathy. The peak torques in the concentric, eccentric, and isometric contractions were evaluated using an isokinetic dynamometer during knee and ankle flexion and extension. FINDINGS: Individuals with diabetes and diabetic peripheral neuropathy presented similar low concentric and isometric knee and ankle torques that were also lower than the controls. However, the eccentric torque was similar among the groups, the contractions, and the joints. INTERPRETATION: Regardless of the presence of peripheral neuropathy, differences in skeletal muscle function were found. The muscle involvement does not follow the same pattern of sensorial losses, since there are no distal-to-proximal impairments. Both knee and ankle were affected, but the effect sizes of the concentric and isometric torques were found to be greater in the participants' knees than in their ankles. The eccentric function did not reveal differences between the healthy control group and the two diabetic groups, raising questions about the involvement of the passive muscle components.
BACKGROUND: Skeletal muscle strength is poorly described and understood in diabeticparticipants with diabetic peripheral neuropathy. This study aimed to investigate the extensor and flexor torque of the knee and ankle during concentric, eccentric, and isometric contractions in men with diabetes mellitus type 2 with and without diabetic peripheral neuropathy. METHODS: Three groups of adult men (n=92), similar in age, body mass index, and testosterone levels, were analyzed: 33 non-diabetic controls, 31 with type 2 diabetes mellitus, and 28 with diabetic peripheral neuropathy. The peak torques in the concentric, eccentric, and isometric contractions were evaluated using an isokinetic dynamometer during knee and ankle flexion and extension. FINDINGS: Individuals with diabetes and diabetic peripheral neuropathy presented similar low concentric and isometric knee and ankle torques that were also lower than the controls. However, the eccentric torque was similar among the groups, the contractions, and the joints. INTERPRETATION: Regardless of the presence of peripheral neuropathy, differences in skeletal muscle function were found. The muscle involvement does not follow the same pattern of sensorial losses, since there are no distal-to-proximal impairments. Both knee and ankle were affected, but the effect sizes of the concentric and isometric torques were found to be greater in the participants' knees than in their ankles. The eccentric function did not reveal differences between the healthy control group and the two diabetic groups, raising questions about the involvement of the passive muscle components.
Authors: Cristina D Sartor; Mariana D Oliveira; Victoria Campos; Jane S S P Ferreira; Isabel C N Sacco Journal: Braz J Phys Ther Date: 2017-11-15 Impact factor: 3.377
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Authors: Birgit L M Van Eetvelde; Dirk Cambier; Karsten Vanden Wyngaert; Bert Celie; Patrick Calders Journal: J Diabetes Res Date: 2018-11-29 Impact factor: 4.011
Authors: Y C Estrada-Bonilla; P A T S Castro; G L F Luna; A B A Souza; G S Santos; T F Salvini; A M O Leal; T L Russo Journal: Braz J Med Biol Res Date: 2020-06-03 Impact factor: 2.590
Authors: Birgit L M Van Eetvelde; Bruno Lapauw; Pascal Proot; Karsten Vanden Wyngaert; Simon Helleputte; Jan Stautemas; Dirk C Cambier; Patrick Calders Journal: J Musculoskelet Neuronal Interact Date: 2021-12-01 Impact factor: 2.041
Authors: J P Ferreira; A M O Leal; F A Vasilceac; C D Sartor; I C N Sacco; A S Soares; T F Salvini Journal: Braz J Med Biol Res Date: 2018-07-23 Impact factor: 2.590