Literature DB >> 28212803

Calcium Channels in Vascular Smooth Muscle.

D Ghosh1, A U Syed1, M P Prada1, M A Nystoriak2, L F Santana1, M Nieves-Cintrón1, M F Navedo3.   

Abstract

Calcium (Ca2+) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+ concentration ([Ca2+]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca2+-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca2+]i. In this review, we discuss the major Ca2+-permeable channels expressed in VSM and their contribution to vascular physiology and pathology.
© 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Arteries; Ca(2+) signaling; Contraction; Ion channels; Myogenic tone; Sarcoplasmic reticulum

Mesh:

Substances:

Year:  2016        PMID: 28212803      PMCID: PMC5439506          DOI: 10.1016/bs.apha.2016.08.002

Source DB:  PubMed          Journal:  Adv Pharmacol        ISSN: 1054-3589


  192 in total

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