| Literature DB >> 28212803 |
D Ghosh1, A U Syed1, M P Prada1, M A Nystoriak2, L F Santana1, M Nieves-Cintrón1, M F Navedo3.
Abstract
Calcium (Ca2+) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+ concentration ([Ca2+]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca2+-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca2+]i. In this review, we discuss the major Ca2+-permeable channels expressed in VSM and their contribution to vascular physiology and pathology.Entities:
Keywords: Arteries; Ca(2+) signaling; Contraction; Ion channels; Myogenic tone; Sarcoplasmic reticulum
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Year: 2016 PMID: 28212803 PMCID: PMC5439506 DOI: 10.1016/bs.apha.2016.08.002
Source DB: PubMed Journal: Adv Pharmacol ISSN: 1054-3589