Jin-Yi Li1, Yan He1, Hong-Hong Ke1, Yu Jin2, Zhi-Yuan Jiang1, Guo-Qiang Zhong1. 1. Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. 2. Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
Abstract
BACKGROUND: Oxidative stress and inflammatory processes are responsible for the pathogenesis of AF, but their relationship with the sizes of the LA and PVs in AF patients remains unclear. HYPOTHESIS: Oxidative stress and inflammatory processes are associated with the sizes of the LA and PVs in AF patients. METHODS: 82 AF patients were compared to 30 control patients by using a case-control study design. Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were detected. RESULTS: (1) Hs-CRP, IL-6, IL-8, TNF-α, MDA and ox-LDL were higher, and SOD was lower in AF patients than in control patients. Hs-CRP, MDA and ox-LDL were higher in permanent AF patients than in paroxysmal and persistent AF patients. (2) CsA of LSPV, RSPV, RIPV, LAA and LAV were statistically higher in AF patients than in control patients. CsA of RSPV, LSPV, LIPV and LAV were higher in permanent AF patients than in paroxysmal and persistent AF patients. (3) In the AF group, hs-CRP and TNF-α were positively correlated with LAV; MDA was positively correlated with CsA of LAA, LSPV and LAV; SOD was passively correlated with CsA of LAA and LAV; ox-LDL was positively correlated with CsA of LAA and LAV. Multivariate logistic regression analysis showed hs-CRP, ox-LDL, RSPV CsA, LIPV CsA and LAV were associated with AF. CONCLUSIONS: Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were significantly increased in AF patients. Hs-CRP, ox-LDL, RSPV CsA, LIPV CsA and LAV were associated with AF persistence.
BACKGROUND: Oxidative stress and inflammatory processes are responsible for the pathogenesis of AF, but their relationship with the sizes of the LA and PVs in AFpatients remains unclear. HYPOTHESIS: Oxidative stress and inflammatory processes are associated with the sizes of the LA and PVs in AFpatients. METHODS: 82 AFpatients were compared to 30 control patients by using a case-control study design. Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were detected. RESULTS: (1) Hs-CRP, IL-6, IL-8, TNF-α, MDA and ox-LDL were higher, and SOD was lower in AFpatients than in control patients. Hs-CRP, MDA and ox-LDL were higher in permanent AFpatients than in paroxysmal and persistent AFpatients. (2) CsA of LSPV, RSPV, RIPV, LAA and LAV were statistically higher in AFpatients than in control patients. CsA of RSPV, LSPV, LIPV and LAV were higher in permanent AFpatients than in paroxysmal and persistent AFpatients. (3) In the AF group, hs-CRP and TNF-α were positively correlated with LAV; MDA was positively correlated with CsA of LAA, LSPV and LAV; SOD was passively correlated with CsA of LAA and LAV; ox-LDL was positively correlated with CsA of LAA and LAV. Multivariate logistic regression analysis showed hs-CRP, ox-LDL, RSPV CsA, LIPVCsA and LAV were associated with AF. CONCLUSIONS: Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were significantly increased in AFpatients. Hs-CRP, ox-LDL, RSPV CsA, LIPVCsA and LAV were associated with AF persistence.
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