Adolfo M García1, Lucas Sedeño1, Natalia Trujillo2, Yamile Bocanegra3, Diana Gomez2, David Pineda3, Andrés Villegas4, Edinson Muñoz5, William Arias6, Agustín Ibáñez1. 1. 1Laboratory of Experimental Psychology and Neuroscience (LPEN),Institute of Cognitive and Translational Neuroscience (INCyT),INECO Foundation,Favaloro University,Buenos Aires,Argentina. 2. 4Mental Health Group,School of Public Health,University of Antioquia (UDEA),Medellín,Colombia. 3. 5Group of Neuropsychology and Conduct (GRUNECO), Faculty of Medicine,University of Antioquia (UDEA),Medellín,Colombia. 4. 6Neuroscience Group, Faculty of Medicine,University of Antioquia (UDEA),Medellín,Colombia. 5. 7Departamento de Lingüística y Literatura, Facultad de Humanidades,Universidad de Santiago de Chile,Santiago,Chile. 6. 8Molecular Genetics Laboratory,University of Antioquia (UDEA),Medellín,Colombia.
Abstract
OBJECTIVES: The worldwide spread of Parkinson's disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here, we use language measures revealing deficits in PD to explore whether similar disturbances are present in asymptomatic individuals at risk for the disease. METHODS: We administered executive, semantic, verb-production, and syntactic tasks to sporadic PD patients, genetic PD patients with PARK2 (parkin) or LRRK2 (dardarin) mutation, asymptomatic first-degree relatives of the latter with similar mutations, and socio-demographically matched controls. Moreover, to detect sui generis language disturbances, we ran analysis of covariance tests using executive functions as covariate. RESULTS: The two clinical groups showed impairments in all measures, most of which survived covariation with executive functions. However, the key finding concerned asymptomatic mutation carriers. While these subjects showed intact executive, semantic, and action-verb production skills, they evinced deficits in a syntactic test with minimal working memory load. CONCLUSIONS: We propose that this sui generis disturbance may constitute a prodromal sign anticipating eventual development of PD. Moreover, our results suggest that mutations on specific genes (PARK2 and LRRK2) compromising basal ganglia functioning may be subtly related to language-processing mechanisms. (JINS, 2017, 23, 150-158).
OBJECTIVES: The worldwide spread of Parkinson's disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here, we use language measures revealing deficits in PD to explore whether similar disturbances are present in asymptomatic individuals at risk for the disease. METHODS: We administered executive, semantic, verb-production, and syntactic tasks to sporadic PDpatients, genetic PDpatients with PARK2 (parkin) or LRRK2 (dardarin) mutation, asymptomatic first-degree relatives of the latter with similar mutations, and socio-demographically matched controls. Moreover, to detect sui generis language disturbances, we ran analysis of covariance tests using executive functions as covariate. RESULTS: The two clinical groups showed impairments in all measures, most of which survived covariation with executive functions. However, the key finding concerned asymptomatic mutation carriers. While these subjects showed intact executive, semantic, and action-verb production skills, they evinced deficits in a syntactic test with minimal working memory load. CONCLUSIONS: We propose that this sui generis disturbance may constitute a prodromal sign anticipating eventual development of PD. Moreover, our results suggest that mutations on specific genes (PARK2 and LRRK2) compromising basal ganglia functioning may be subtly related to language-processing mechanisms. (JINS, 2017, 23, 150-158).
Authors: Cheryl M Corcoran; Vijay A Mittal; Carrie E Bearden; Raquel E Gur; Kasia Hitczenko; Zarina Bilgrami; Aleksandar Savic; Guillermo A Cecchi; Phillip Wolff Journal: Schizophr Res Date: 2020-06-01 Impact factor: 4.939
Authors: Elif Eyigoz; Melody Courson; Lucas Sedeño; Katharina Rogg; Juan Rafael Orozco-Arroyave; Elmar Nöth; Sabine Skodda; Natalia Trujillo; Mabel Rodríguez; Jan Rusz; Edinson Muñoz; Juan F Cardona; Eduar Herrera; Eugenia Hesse; Agustín Ibáñez; Guillermo Cecchi; Adolfo M García Journal: Cortex Date: 2020-09-08 Impact factor: 4.027
Authors: Agustín Ibáñez; Lucas Sedeño; Adolfo M García; Robert M J Deacon; Patricia Cogram Journal: Front Aging Neurosci Date: 2018-04-06 Impact factor: 5.750