Guillaume Geri1, Florence Dumas2, Franck Bonnetain3, Wulfran Bougouin1, Benoit Champigneulle4, Michel Arnaout4, Pierre Carli5, Eloi Marijon6, Olivier Varenne7, Jean-Paul Mira4, Jean-Philippe Empana8, Alain Cariou9. 1. Medical ICU, Cochin Hospital, APHP, Paris, France; Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France. 2. Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France; Emergency Department, Cochin Hospital, Paris, France. 3. Methodological and Quality of Life Unit in Oncology (EA3181) - University Hospital of Besançon, France. 4. Medical ICU, Cochin Hospital, APHP, Paris, France; Université Paris-Descartes, Paris, France. 5. Sudden Death Expertise Centre, Paris, France; SAMU 75, France. 6. Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France; Cardiology Department, Pompidou Hospital, APHP, Paris, France. 7. Université Paris-Descartes, Paris, France; Cardiology Department, Cochin Hospital, Paris, France. 8. Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France. 9. Medical ICU, Cochin Hospital, APHP, Paris, France; Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France. Electronic address: alain.cariou@aphp.fr.
Abstract
BACKGROUND: Even if a large majority of out-of-hospital cardiac arrest (OHCA) survivors appear to have a good neurological recovery with no important sequellae, whether health-related quality of life (HRQOL) is altered is less explored. PATIENTS AND METHODS: HRQOL was evaluated by telephone interview using SF-36 questionnaire. Each OHCA case was age and gender-matched with 4 controls from the French general population. Association between current condition of the survivors with the 8 dimensions of the SF-36 questionnaire was investigated using MANCOVA. Cluster analysis was performed to identify patterns of HRQOL among CPC1 survivors. RESULTS: 255 patients discharged alive from our referral centre between 2000 and 2013 (median age of 55y [45,64], 73.7% males) were interviewed. Global physical and mental components did not differ between CPC 1 survivors and controls (47.0 vs. 47.1, p=0.88 and 46.4 vs. 46.9, p=0.45) but substantially differed between CPC2, CPC3 and the corresponding controls. Younger age, male gender, good neurological recovery and daily-life autonomy at telephone interview were significantly associated with better scores in each SF-36 dimensions. Cluster analysis individualized 4 distinct subgroups of CPC1 patients characterised by progressively increased score of SF-36. Return to work and daily-life autonomy were differently distributed across these 4 groups while pre-hospital Utstein variables were not. CONCLUSION: HRQOL of CPC1 OHCA survivors appeared similar to that of the general population, but patients with CPC2 or 3 had altered HRQOL. Younger age, male gender, good neurological recovery and daily-life autonomy were independently associated with a better HRQOL.
BACKGROUND: Even if a large majority of out-of-hospital cardiac arrest (OHCA) survivors appear to have a good neurological recovery with no important sequellae, whether health-related quality of life (HRQOL) is altered is less explored. PATIENTS AND METHODS: HRQOL was evaluated by telephone interview using SF-36 questionnaire. Each OHCA case was age and gender-matched with 4 controls from the French general population. Association between current condition of the survivors with the 8 dimensions of the SF-36 questionnaire was investigated using MANCOVA. Cluster analysis was performed to identify patterns of HRQOL among CPC1 survivors. RESULTS: 255 patients discharged alive from our referral centre between 2000 and 2013 (median age of 55y [45,64], 73.7% males) were interviewed. Global physical and mental components did not differ between CPC 1 survivors and controls (47.0 vs. 47.1, p=0.88 and 46.4 vs. 46.9, p=0.45) but substantially differed between CPC2, CPC3 and the corresponding controls. Younger age, male gender, good neurological recovery and daily-life autonomy at telephone interview were significantly associated with better scores in each SF-36 dimensions. Cluster analysis individualized 4 distinct subgroups of CPC1 patients characterised by progressively increased score of SF-36. Return to work and daily-life autonomy were differently distributed across these 4 groups while pre-hospital Utstein variables were not. CONCLUSION: HRQOL of CPC1 OHCA survivors appeared similar to that of the general population, but patients with CPC2 or 3 had altered HRQOL. Younger age, male gender, good neurological recovery and daily-life autonomy were independently associated with a better HRQOL.
Authors: Jerry P Nolan; Robert A Berg; Clifton W Callaway; Laurie J Morrison; Vinay Nadkarni; Gavin D Perkins; Claudio Sandroni; Markus B Skrifvars; Jasmeet Soar; Kjetil Sunde; Alain Cariou Journal: Intensive Care Med Date: 2018-06-02 Impact factor: 17.440
Authors: Katharyn L Flickinger; Stephany Jaramillo; Melissa J Repine; Allison C Koller; Margo Holm; Elizabeth Skidmore; Clif Callaway; Jon C Rittenberger Journal: Resusc Plus Date: 2021-12-06
Authors: Jerry P Nolan; Claudio Sandroni; Bernd W Böttiger; Alain Cariou; Tobias Cronberg; Hans Friberg; Cornelia Genbrugge; Kirstie Haywood; Gisela Lilja; Véronique R M Moulaert; Nikolaos Nikolaou; Theresa Mariero Olasveengen; Markus B Skrifvars; Fabio Taccone; Jasmeet Soar Journal: Intensive Care Med Date: 2021-03-25 Impact factor: 17.440
Authors: Stephany Jaramillo; Katharyn L Flickinger; Melissa Repine; Maria Pacella-LaBarbara; Clifton W Callaway; Allison Koller; Kevin Cullison; Jon C Rittenberger Journal: Resuscitation Date: 2020-03-10 Impact factor: 6.251
Authors: Julian Müller; Michael Behnes; Tobias Schupp; Linda Reiser; Gabriel Taton; Thomas Reichelt; Dominik Ellguth; Martin Borggrefe; Niko Engelke; Armin Bollow; Seung-Hyun Kim; Kathrin Weidner; Uzair Ansari; Kambis Mashayekhi; Muharrem Akin; Philipp Halbfass; Dirk Große Meininghaus; Ibrahim Akin; Jonas Rusnak Journal: Heart Vessels Date: 2021-11-16 Impact factor: 2.037