Literature DB >> 28197541

Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks.

Valentina Palermo1, Sara Rinalducci2, Massimo Sanchez3, Francesca Grillini1, Annapaola Franchitto4, Pietro Pichierri1.   

Abstract

Replication-dependent double-strand breaks (DSBs) are the main source of genomic instability as their inaccurate repair stimulates chromosomal rearrangements. In a recent work, we uncover a novel regulatory circuit that involves the Werner's syndrome helicase and CDK1, and that is essential for repair pathway choice at replication-dependent DSBs.

Entities:  

Keywords:  DNA repair; WRN protein; end-resection

Year:  2016        PMID： 28197541      PMCID： PMC5286962          DOI： 10.1080/23723556.2016.1268243

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Genomic instability--an evolving hallmark of cancer.

Authors:  Simona Negrini; Vassilis G Gorgoulis; Thanos D Halazonetis
Journal:  Nat Rev Mol Cell Biol       Date:  2010-03       Impact factor: 94.444

Review 2.  DNA replication and oncogene-induced replicative stress.

Authors:  Stephanie A Hills; John F X Diffley
Journal:  Curr Biol       Date:  2014-05-19       Impact factor: 10.834

3.  DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.

Authors:  Andreas Sturzenegger; Kamila Burdova; Radhakrishnan Kanagaraj; Maryna Levikova; Cosimo Pinto; Petr Cejka; Pavel Janscak
Journal:  J Biol Chem       Date:  2014-08-13       Impact factor: 5.157

Review 4.  Repair Pathway Choices and Consequences at the Double-Strand Break.

Authors:  Raphael Ceccaldi; Beatrice Rondinelli; Alan D D'Andrea
Journal:  Trends Cell Biol       Date:  2015-10-01       Impact factor: 20.808

5.  Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle.

Authors:  P Pichierri; A Franchitto; P Mosesso; L Proietti de Santis; A S Balajee; F Palitti
Journal:  Mutat Res       Date:  2000-03-20       Impact factor: 2.433

6.  Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage.

Authors:  P Pichierri; A Franchitto; P Mosesso; F Palitti
Journal:  Mutat Res       Date:  2000-11-30       Impact factor: 2.433

Review 7.  Roles of eukaryotic topoisomerases in transcription, replication and genomic stability.

Authors:  Yves Pommier; Yilun Sun; Shar-Yin N Huang; John L Nitiss
Journal:  Nat Rev Mol Cell Biol       Date:  2016-09-21       Impact factor: 113.915

Review 8.  The Werner syndrome protein: linking the replication checkpoint response to genome stability.

Authors:  Pietro Pichierri; Francesca Ammazzalorso; Margherita Bignami; Annapaola Franchitto
Journal:  Aging (Albany NY)       Date:  2011-03       Impact factor: 5.682

9.  CDK1 phosphorylates WRN at collapsed replication forks.

Authors:  Valentina Palermo; Sara Rinalducci; Massimo Sanchez; Francesca Grillini; Joshua A Sommers; Robert M Brosh; Lello Zolla; Annapaola Franchitto; Pietro Pichierri
Journal:  Nat Commun       Date:  2016-09-16       Impact factor: 14.919

10.  Replication stress links structural and numerical cancer chromosomal instability.

Authors:  Rebecca A Burrell; Sarah E McClelland; David Endesfelder; Petra Groth; Marie-Christine Weller; Nadeem Shaikh; Enric Domingo; Nnennaya Kanu; Sally M Dewhurst; Eva Gronroos; Su Kit Chew; Andrew J Rowan; Arne Schenk; Michal Sheffer; Michael Howell; Maik Kschischo; Axel Behrens; Thomas Helleday; Jiri Bartek; Ian P Tomlinson; Charles Swanton
Journal:  Nature       Date:  2013-02-28       Impact factor: 49.962
  10 in total
  4 in total

1.  Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation.

Authors:  Dipon Das; Molly L Bristol; Nathan W Smith; Claire D James; Xu Wang; Pietro Pichierri; Iain M Morgan
Journal:  mBio       Date:  2019-03-19       Impact factor: 7.867

Review 2.  Using a Human Papillomavirus Model to Study DNA Replication and Repair of Wild Type and Damaged DNA Templates in Mammalian Cells.

Authors:  Dipon Das; Molly L Bristol; Pietro Pichierri; Iain M Morgan
Journal:  Int J Mol Sci       Date:  2020-10-13       Impact factor: 5.923

Review 3.  Activating the DNA Damage Response and Suppressing Innate Immunity: Human Papillomaviruses Walk the Line.

Authors:  Claire D James; Dipon Das; Molly L Bristol; Iain M Morgan
Journal:  Pathogens       Date:  2020-06-13

4.  Werner Syndrome Protein (WRN) Regulates Cell Proliferation and the Human Papillomavirus 16 Life Cycle during Epithelial Differentiation.

Authors:  Claire D James; Dipon Das; Ethan L Morgan; Raymonde Otoa; Andrew Macdonald; Iain M Morgan
Journal:  mSphere       Date:  2020-09-16       Impact factor: 4.389
  4 in total

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