Literature DB >> 28197540

An RB insensitive to CDK regulation.

Manel Joaquin1, Eulàlia de Nadal1, Francesc Posas1.   

Abstract

The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays tumor cell growth. This novel mechanism of RB regulation opens up a window for developing new cancer drug treatments for tumors harboring high CDK-Cyclin activity and a wild-type RB gene.

Entities:  

Keywords:  CDK; Cellular stress; p38; retinoblastoma; tumor suppressor

Year:  2016        PMID： 28197540      PMCID： PMC5286971          DOI： 10.1080/23723556.2016.1268242

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  RB: mitotic implications of a tumour suppressor.

Authors:  Amity L Manning; Nicholas J Dyson
Journal:  Nat Rev Cancer       Date:  2012-02-09       Impact factor: 60.716

Review 2.  The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses.

Authors:  Alba Duch; Eulàlia de Nadal; Francesc Posas
Journal:  FEBS Lett       Date:  2012-07-20       Impact factor: 4.124

3.  The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells.

Authors:  Albert Gubern; Manel Joaquin; Miriam Marquès; Pedro Maseres; Javier Garcia-Garcia; Ramon Amat; Daniel González-Nuñez; Baldo Oliva; Francisco X Real; Eulàlia de Nadal; Francesc Posas
Journal:  Mol Cell       Date:  2016-09-15       Impact factor: 17.970

Review 4.  Signal integration by JNK and p38 MAPK pathways in cancer development.

Authors:  Erwin F Wagner; Angel R Nebreda
Journal:  Nat Rev Cancer       Date:  2009-08       Impact factor: 60.716

Review 5.  Molecular mechanisms underlying RB protein function.

Authors:  Frederick A Dick; Seth M Rubin
Journal:  Nat Rev Mol Cell Biol       Date:  2013-04-18       Impact factor: 94.444

Review 6.  Deciphering the retinoblastoma protein phosphorylation code.

Authors:  Seth M Rubin
Journal:  Trends Biochem Sci       Date:  2012-12-03       Impact factor: 13.807

Review 7.  Response to hyperosmotic stress.

Authors:  Haruo Saito; Francesc Posas
Journal:  Genetics       Date:  2012-10       Impact factor: 4.562

8.  The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle.

Authors:  Shauna A Henley; Frederick A Dick
Journal:  Cell Div       Date:  2012-03-14       Impact factor: 5.130

9.  A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress.

Authors:  Manel Joaquin; Albert Gubern; Francesc Posas
Journal:  Cell Cycle       Date:  2012-08-23       Impact factor: 4.534

10.  The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress.

Authors:  Manel Joaquin; Albert Gubern; Daniel González-Nuñez; E Josué Ruiz; Isabel Ferreiro; Eulalia de Nadal; Angel R Nebreda; Francesc Posas
Journal:  EMBO J       Date:  2012-05-08       Impact factor: 11.598
  10 in total
  3 in total

Review 1.  The p38 Pathway: From Biology to Cancer Therapy.

Authors:  Adrián Martínez-Limón; Manel Joaquin; María Caballero; Francesc Posas; Eulàlia de Nadal
Journal:  Int J Mol Sci       Date:  2020-03-11       Impact factor: 5.923

Review 2.  Understanding Retinoblastoma Post-Translational Regulation for the Design of Targeted Cancer Therapies.

Authors:  Radoslav Janostiak; Ariadna Torres-Sanchez; Francesc Posas; Eulàlia de Nadal
Journal:  Cancers (Basel)       Date:  2022-02-28       Impact factor: 6.639

3.  The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis.

Authors:  Javier Jiménez; Ethel Queralt; Francesc Posas; Eulàlia de Nadal
Journal:  Cell Cycle       Date:  2020-08-14       Impact factor: 4.534
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.