| Literature DB >> 28189312 |
Daniel T Nagasawa1, Carlito Lagman1, Michael Sun1, Andrew Yew1, Lawrance K Chung1, Seung J Lee1, Timothy T Bui1, Yinn Cher Ooi1, R Aaron Robison2, Gabriel Zada2, Isaac Yang3.
Abstract
Pineal germ cell tumors (GCTs) are primarily seen in pediatric and Asian populations. These tumors are divided into germinomatous and non-germinomatous GCTs (NGGCTs). GCTs are thought to arise by misplacement of totipotent stem cells en route to gonads during embryogenesis. Intracranial GCTs display an affinity to develop along the pineal-suprasellar axis and have variable manifestations dependent upon the location of the tumor. Management and outcomes are driven by histopathologies. In this study, we highlight two cases of pineal GCTs and present a review of the literature with an emphasis on histopathologies and biomarkers.Entities:
Keywords: Germ cell tumor; Germinoma; Intracranial neoplasms; Pathology; Yolk sac tumor
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Year: 2017 PMID： 28189312 PMCID： PMC8908809 DOI： 10.1016/j.jocn.2016.12.024
Source DB: PubMed Journal: J Clin Neurosci ISSN： 0967-5868 Impact factor: 1.961