| Literature DB >> 28188471 |
Kwitae Chong1, Chenfanfu Jiang2, Daniel Ram3, Anand Santhanam4, Demetri Terzopoulos2, Peyman Benharash5, Erik Dutson5, Joseph Teran3, Jeff D Eldredge6.
Abstract
A tandem of particle-based computational methods is adapted to simulate injury and hemorrhage in the human body. In order to ensure anatomical fidelity, a three-dimensional model of a targeted portion of the human body is reconstructed from a dense sequence of CT scans of an anonymized patient. Skin, bone and muscular tissue are distinguished in the imaging data and assigned with their respective material properties. An injury geometry is then generated by simulating the mechanics of a ballistic projectile passing through the anatomical model with the material point method. From the injured vascular segments identified in the resulting geometry, smoothed particle hydrodynamics (SPH) is employed to simulate bleeding, based on inflow boundary conditions obtained from a network model of the systemic arterial tree. Computational blood particles interact with the stationary particles representing impermeable bone and skin and permeable muscular tissue through the Brinkman equations for porous media. The SPH results are rendered in post-processing for improved visual fidelity. The overall simulation strategy is demonstrated on an injury scenario in the lower leg.Entities:
Keywords: Cardiovascular tree model; Hemorrhage simulation; Injury biomechanics; Material point method; Smoothed particle hydrodynamics
Mesh:
Year: 2017 PMID: 28188471 DOI: 10.1007/s11517-017-1619-9
Source DB: PubMed Journal: Med Biol Eng Comput ISSN: 0140-0118 Impact factor: 2.602