I M Aris1, J Y Bernard1, L-W Chen2, M T Tint3, W Y Lim4, S E Soh1, S-M Saw4, L P-C Shek2, K M Godfrey5, P D Gluckman1,6, Y-S Chong1,3, F Yap7,8,9, M S Kramer3,10, Y S Lee1,2,11. 1. Singapore Institute for Clinical Sciences, Agency for Science, Technology, Singapore, Singapore. 2. Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 3. Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 4. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. 5. MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, England, UK. 6. Liggins Institute, University of Auckland, Auckland, New Zealand. 7. Department of Pediatrics, KK Women's and Children's Hospital, Singapore, Singapore. 8. Duke-NUS Medical School, Singapore, Singapore. 9. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. 10. Departments of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Quebec, Canada. 11. Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Abstract
OBJECTIVE: There have been hypotheses that early life adiposity gain may influence blood pressure (BP) later in life. We examined associations between timing of height, body mass index (BMI) and adiposity gains in early life with BP at 48 months in an Asian pregnancy-birth cohort. METHODS: In 719 children, velocities for height, BMI and abdominal circumference (AC) were calculated at five intervals [0-3, 3-12, 12-24, 24-36 and 36-48 months]. Triceps (TS) and subscapular skinfold (SS) velocities were calculated between 0-18, 18-36 and 36-48 months. Systolic (SBP) and diastolic blood pressure (DBP) was measured at 48 months. Growth velocities at later periods were adjusted for growth velocities in preceding intervals, as well as measurements at birth. RESULTS: After adjusting for confounders and child height at BP measurement, each unit z-score gain in BMI, AC, TS and SS velocities at 36-48 months were associated with 2.3 (95% CI:1.6, 3.1), 2.1 (1.3, 2.8), 1.4 (0.6, 2.2) and 1.8 (1, 2.6) mmHg higher SBP respectively, and 0.9 (0.4, 1.4), 0.9 (0.4, 1.3), 0.6 (0.1, 1.1) and 0.8 (0.3, 1.3) mmHg higher DBP respectively. BMI and adiposity velocities (AC, TS or SS) at various intervals in the first 36 months however, were not associated with BP. Faster BMI, AC, TS and SS velocities, but not height, at 36-48 months were associated with 0.22 (0.15, 0.29), 0.17 (0.10, 0.24), 0.11 (0.04, 0.19) and 0.15 (0.08, 0.23) units higher SBP z-score respectively, and OR=1.46 (95% CI: 1.13-1.90), 1.49 (1.17-1.92), 1.45 (1.09-1.92) and 1.43 (1.09, 1.88) times higher risk of prehypertension/hypertension respectively at 48 months. CONCLUSIONS: Our results indicated that faster BMI and adiposity (AC, TS or SS) velocities only at the preceding interval before 48 months (36-48 months), but not at earlier intervals in the first 36 months, are predictive of BP and prehypertension/hypertension at 48 months.
OBJECTIVE: There have been hypotheses that early life adiposity gain may influence blood pressure (BP) later in life. We examined associations between timing of height, body mass index (BMI) and adiposity gains in early life with BP at 48 months in an Asian pregnancy-birth cohort. METHODS: In 719 children, velocities for height, BMI and abdominal circumference (AC) were calculated at five intervals [0-3, 3-12, 12-24, 24-36 and 36-48 months]. Triceps (TS) and subscapular skinfold (SS) velocities were calculated between 0-18, 18-36 and 36-48 months. Systolic (SBP) and diastolic blood pressure (DBP) was measured at 48 months. Growth velocities at later periods were adjusted for growth velocities in preceding intervals, as well as measurements at birth. RESULTS: After adjusting for confounders and child height at BP measurement, each unit z-score gain in BMI, AC, TS and SS velocities at 36-48 months were associated with 2.3 (95% CI:1.6, 3.1), 2.1 (1.3, 2.8), 1.4 (0.6, 2.2) and 1.8 (1, 2.6) mmHg higher SBP respectively, and 0.9 (0.4, 1.4), 0.9 (0.4, 1.3), 0.6 (0.1, 1.1) and 0.8 (0.3, 1.3) mmHg higher DBP respectively. BMI and adiposity velocities (AC, TS or SS) at various intervals in the first 36 months however, were not associated with BP. Faster BMI, AC, TS and SS velocities, but not height, at 36-48 months were associated with 0.22 (0.15, 0.29), 0.17 (0.10, 0.24), 0.11 (0.04, 0.19) and 0.15 (0.08, 0.23) units higher SBP z-score respectively, and OR=1.46 (95% CI: 1.13-1.90), 1.49 (1.17-1.92), 1.45 (1.09-1.92) and 1.43 (1.09, 1.88) times higher risk of prehypertension/hypertension respectively at 48 months. CONCLUSIONS: Our results indicated that faster BMI and adiposity (AC, TS or SS) velocities only at the preceding interval before 48 months (36-48 months), but not at earlier intervals in the first 36 months, are predictive of BP and prehypertension/hypertension at 48 months.
Authors: Caryl A Nowson; Sarah R Crozier; Siân M Robinson; Keith M Godfrey; Wendy T Lawrence; Catherine M Law; Cyrus Cooper; Hazel M Inskip Journal: BMJ Open Date: 2014-07-03 Impact factor: 2.692
Authors: Wai-Yee Lim; Yung-Seng Lee; Fabian Kok-Peng Yap; Izzudin Mohd Aris; Ngee Lek; Michael Meaney; Peter D Gluckman; Keith M Godfrey; Kenneth Kwek; Yap-Seng Chong; Seang-Mei Saw; An Pan Journal: Medicine (Baltimore) Date: 2015-11 Impact factor: 1.817
Authors: Izzuddin M Aris; Sheryl L Rifas-Shiman; Ling-Jun Li; Ken P Kleinman; Brent A Coull; Diane R Gold; Marie-France Hivert; Michael S Kramer; Emily Oken Journal: Int J Epidemiol Date: 2019-02-01 Impact factor: 7.196
Authors: Xun Zhang; Kate Tilling; Richard M Martin; Emily Oken; Ashley I Naimi; Izzuddin M Aris; Seungmi Yang; Michael S Kramer Journal: Int J Epidemiol Date: 2019-02-01 Impact factor: 7.196
Authors: Xun Zhang; Richard M Martin; Emily Oken; Izzuddin M Aris; Seungmi Yang; Michael S Kramer Journal: Am J Epidemiol Date: 2020-04-02 Impact factor: 4.897
Authors: Yi Ying Ong; Suresh Anand Sadananthan; Izzuddin M Aris; Mya Thway Tint; Wen Lun Yuan; Jonathan Y Huang; Yiong Huak Chan; Sharon Ng; See Ling Loy; Sendhil S Velan; Marielle V Fortier; Keith M Godfrey; Lynette Shek; Kok Hian Tan; Peter D Gluckman; Fabian Yap; Jonathan Tze Liang Choo; Lieng Hsi Ling; Karen Tan; Li Chen; Neerja Karnani; Yap-Seng Chong; Johan G Eriksson; Mary E Wlodek; Shiao-Yng Chan; Yung Seng Lee; Navin Michael Journal: Int J Epidemiol Date: 2020-10-01 Impact factor: 7.196
Authors: Yi Ying Ong; Jonathan Y Huang; Navin Michael; Suresh Anand Sadananthan; Wen Lun Yuan; Ling-Wei Chen; Neerja Karnani; S Sendhil Velan; Marielle V Fortier; Kok Hian Tan; Peter D Gluckman; Fabian Yap; Yap-Seng Chong; Keith M Godfrey; Mary F-F Chong; Shiao-Yng Chan; Yung Seng Lee; Mya-Thway Tint; Johan G Eriksson Journal: J Clin Endocrinol Metab Date: 2021-04-23 Impact factor: 5.958
Authors: Izzuddin M Aris; Ling-Wei Chen; Mya Thway Tint; Wei Wei Pang; Shu E Soh; Seang-Mei Saw; Lynette Pei-Chi Shek; Kok-Hian Tan; Peter D Gluckman; Yap-Seng Chong; Fabian Yap; Keith M Godfrey; Michael S Kramer; Yung Seng Lee Journal: Sci Rep Date: 2017-08-21 Impact factor: 4.379
Authors: Karen M Eny; Jonathon L Maguire; David W H Dai; Gerald Lebovic; Khosrow Adeli; Jill K Hamilton; Anthony J Hanley; Muhammad Mamdani; Brian W McCrindle; Mark S Tremblay; Patricia C Parkin; Catherine S Birken Journal: Int J Obes (Lond) Date: 2019-04-02 Impact factor: 5.095
Authors: Shirong Cai; Izzuddin M Aris; Wen Lun Yuan; Kok Hian Tan; Keith M Godfrey; Peter D Gluckman; Lynette Pei-Chi Shek; Yap-Seng Chong; Fabian Yap; Marielle V Fortier; Michael J Meaney; Yung Seng Lee; Anqi Qiu Journal: BMJ Open Diabetes Res Care Date: 2021-04