Karim G Kheniser1, Sangeeta R Kashyap2, Philip R Schauer3, Eddie T C Lam4, Emily S Kullman4. 1. Department of Endocrinology and Metabolism, Cleveland Clinic, 9500 Euclid Avenue F20, Cleveland, OH, 44195, USA. 2. Department of Endocrinology and Metabolism, Cleveland Clinic, 9500 Euclid Avenue F20, Cleveland, OH, 44195, USA. Kashyas@ccf.org. 3. Bariatric and Metabolic Institute, Metabolic Translational Research Center, Endocrine and Metabolism Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. 4. Department of Health and Human Performance, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH, 44115, USA.
Abstract
PURPOSE: Although bariatric surgery fosters heightened excess weight loss values, nutritional deficiencies are prominent; one of the most common being iron deficiency anemia. The purpose is to elucidate the frequency of anemia in Roux-en-Y gastric bypass and sleeve gastrectomy subjects. MATERIALS AND METHODS: A retrospective analysis was conducted, in subjects (N = 100) diagnosed with type II diabetes who were randomized into sleeve gastrectomy or Roux-en-Y gastric bypass and intensive medical therapy. RESULTS:Anemia was more common in female subjects who underwentsleeve gastrectomy-roughly half developed microcytosis at 24 months and thereafter. CONCLUSION: The etiology of anemia appears to be iron-related and precipitated by the female sex. Scant iron supplementation is likely causative. However, anemia of chronic inflammation cannot be discounted as being somewhat causal. Subsequently, the aggregate may have had a synergistic influence.
RCT Entities:
PURPOSE: Although bariatric surgery fosters heightened excess weight loss values, nutritional deficiencies are prominent; one of the most common being irondeficiency anemia. The purpose is to elucidate the frequency of anemia in Roux-en-Y gastric bypass and sleeve gastrectomy subjects. MATERIALS AND METHODS: A retrospective analysis was conducted, in subjects (N = 100) diagnosed with type II diabetes who were randomized into sleeve gastrectomy or Roux-en-Y gastric bypass and intensive medical therapy. RESULTS:Anemia was more common in female subjects who underwent sleeve gastrectomy-roughly half developed microcytosis at 24 months and thereafter. CONCLUSION: The etiology of anemia appears to be iron-related and precipitated by the female sex. Scant iron supplementation is likely causative. However, anemia of chronic inflammation cannot be discounted as being somewhat causal. Subsequently, the aggregate may have had a synergistic influence.
Entities:
Keywords:
Anemia of chronic inflammation; Iron deficiency anemia; Metabolic surgery; Nutritional deficiencies; Type II diabetes
Authors: Philip R Schauer; Sangeeta R Kashyap; Kathy Wolski; Stacy A Brethauer; John P Kirwan; Claire E Pothier; Susan Thomas; Beth Abood; Steven E Nissen; Deepak L Bhatt Journal: N Engl J Med Date: 2012-03-26 Impact factor: 91.245