Literature DB >> 28180919

Pathophysiology of Bone Fragility in Patients with Diabetes.

Andrea Palermo1, Luca D'Onofrio2, Raffaella Buzzetti2, Silvia Manfrini1, Nicola Napoli3,4.   

Abstract

It has been well established that bone fragility is one of the chronic complications of diabetes mellitus, and both type 1 and type 2 diabetes are risk factors for fragility fractures. Diabetes may negatively affect bone health by unbalancing several pathways: bone formation, bone resorption, collagen formation, inflammatory cytokine, muscular and incretin system, bone marrow adiposity and calcium metabolism. The purpose of this narrative review is to explore the current understanding of pathophysiological pathways underlying bone fragility in diabetics. In particular, the review will focus on the peculiar cellular and molecular system impairment that may lead to increased risk of fracture in type 1 and type 2 diabetes.

Entities:  

Keywords:  Diabetes; Hyperglycaemia; Osteoblast; Osteoclast; Osteoporosis

Mesh：

Year:  2017        PMID： 28180919     DOI： 10.1007/s00223-016-0226-3

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  18 in total

Review 1.  Bone health in type 1 diabetes.

Authors:  Viral N Shah; R Dana Carpenter; Virginia L Ferguson; Ann V Schwartz
Journal:  Curr Opin Endocrinol Diabetes Obes       Date:  2018-08       Impact factor: 3.243

Review 2.  Lifestyle Management of Diabetes: Implications for the Bone-Vascular Axis.

Authors:  Silvia Pieralice; Francesca Vigevano; Rossella Del Toro; Nicola Napoli; Ernesto Maddaloni
Journal:  Curr Diab Rep       Date:  2018-08-18       Impact factor: 4.810

Review 3.  Osteomacs and Bone Regeneration.

Authors:  Lena Batoon; Susan Marie Millard; Liza Jane Raggatt; Allison Robyn Pettit
Journal:  Curr Osteoporos Rep       Date:  2017-08       Impact factor: 5.096

4.  Serum biomarker-based osteoporosis risk prediction and the systemic effects of Trifolium pratense ethanolic extract in a postmenopausal model.

Authors:  Yixian Quah; Jireh Chan Yi-Le; Na-Hye Park; Yuan Yee Lee; Eon-Bee Lee; Seung-Hee Jang; Min-Jeong Kim; Man Hee Rhee; Seung-Jin Lee; Seung-Chun Park
Journal:  Chin Med       Date:  2022-06-14       Impact factor: 4.546

5.  Caffeine at a Moderate Dose Did Not Affect the Skeletal System of Rats with Streptozotocin-Induced Diabetes.

Authors:  Joanna Folwarczna; Aleksandra Janas; Urszula Cegieła; Maria Pytlik; Leszek Śliwiński; Magdalena Matejczyk; Anna Nowacka; Karolina Rudy; Zora Krivošíková; Kornélia Štefíková; Martin Gajdoš
Journal:  Nutrients       Date:  2017-10-30       Impact factor: 5.717

Review 6.  Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety.

Authors:  Beibei Chen; Lili Wang; Lin Li; Ruyuan Zhu; Haixia Liu; Chenyue Liu; Rufeng Ma; Qiangqiang Jia; Dandan Zhao; Jianzhao Niu; Min Fu; Sihua Gao; Dongwei Zhang
Journal:  Molecules       Date:  2017-09-05       Impact factor: 4.411

7.  Fluorine-contained hydroxyapatite suppresses bone resorption through inhibiting osteoclasts differentiation and function in vitro and in vivo.

Authors:  Shibo Liu; Hao Zhou; Hanghang Liu; Huanzhong Ji; Wei Fei; En Luo
Journal:  Cell Prolif       Date:  2019-04-10       Impact factor: 6.831

8.  Bone quality analysis of jaw bones in individuals with type 2 diabetes mellitus-post mortem anatomical and microstructural evaluation.

Authors:  Teodora Rodic; Eva Maria Wölfel; Petar Milovanovic; Imke A K Fiedler; Danica Cvetkovic; Katharina Jähn; Michael Amling; Jelena Sopta; Slobodan Nikolic; Vladimir Zivkovic; Björn Busse; Marija Djuric
Journal:  Clin Oral Investig       Date:  2021-03-11       Impact factor: 3.573

9.  Diabetes mellitus accelerates the progression of osteoarthritis in streptozotocin-induced diabetic mice by deteriorating bone microarchitecture, bone mineral composition, and bone strength of subchondral bone.

Authors:  Hua-Jun Wang; Hugo Giambini; Ji-Wen Chen; Qiu-Shi Wang; Hui-Ge Hou; Si-Min Luo; Jun-Yuan Chen; Teng-Feng Zhuang; Yuan-Feng Chen; Ting-Ting Wu; Zhen-Gang Zha; You-Jie Liu; Xiao-Fei Zheng
Journal:  Ann Transl Med       Date:  2021-05

10.  Osteoporosis knowledge and beliefs in diabetic patients: a cross sectional study from Palestine.

Authors:  Ghaith A Ishtaya; Yazan M Anabtawi; Sa'ed H Zyoud; Waleed M Sweileh
Journal:  BMC Musculoskelet Disord       Date:  2018-02-07       Impact factor: 2.362
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