Teodora Rodic1, Eva Maria Wölfel2, Petar Milovanovic1,2, Imke A K Fiedler2, Danica Cvetkovic3, Katharina Jähn2, Michael Amling2, Jelena Sopta4, Slobodan Nikolic3, Vladimir Zivkovic3, Björn Busse2, Marija Djuric5. 1. Laboratory for Anthropology and Skeletal Biology, Institute for Anatomy, School of Medicine, University of Belgrade, Dr Subotica starijeg 4, Belgrade, 11000, Serbia. 2. Institute for Osteology and Biomechanics, University Medical Center Hamburg- Eppendorf, Lottestrasse 55, 22529, Hamburg, Germany. 3. Institute for Forensic Medicine, School of Medicine, University of Belgrade, Deligradska 31/A, Belgrade, 11000, Serbia. 4. Institute for Pathology, School of Medicine, University of Belgrade, Dr Subotica starijeg 1, Belgrade, 11000, Serbia. 5. Laboratory for Anthropology and Skeletal Biology, Institute for Anatomy, School of Medicine, University of Belgrade, Dr Subotica starijeg 4, Belgrade, 11000, Serbia. marijadjuric5@gmail.com.
Abstract
OBJECTIVES: With the higher risk of dental implant failure with type 2 diabetes mellitus (T2DM), there is a need to characterize the jaw bones in those individuals. The aim of this post mortem study was to compare jaw bone quality of individuals with T2DM to healthy controls. MATERIAL AND METHODS: Bone cores from the edentulous lower first molar region and the region of mandibular angle were collected from male individuals with T2DM (n = 10, 70.6 ± 4.5 years) and healthy controls (n = 11, 71.5 ± 3.8 years) during autopsy. Within the T2DM, a subgroup treated with oral antidiabetics (OAD) and one on insulin were identified. Bone quality assessment encompassed evaluation of bone microstructure, matrix composition, and cellular activity, using microcomputed tomography (micro-CT), quantitative backscattered electron imaging (qBEI), Raman spectroscopy, and bone histomorphometry. RESULTS: In the mandibular angle, T2DM showed 51% lower porosity of the lingual cortex (p = 0.004) and 21% higher trabecular thickness (p = 0.008) compared to control. More highly mineralized bone packets were found in the buccal cortex of the mandibular angle in insulin-treated compared to OAD-treated T2DM group (p = 0.034). In the molar region, we found higher heterogeneity of trabecular calcium content in T2DM insulin compared to controls (p = 0.015) and T2DM OAD (p = 0.019). T2DM was associated with lower osteocyte lacunar size in the trabecular bone of the molar region (vs. control p = 0.03). CONCLUSIONS: Alterations in microstructure, mineralization, and osteocyte morphology were determined in jaw bone of individuals with T2DM compared to controls. CLINICAL RELEVANCE: Future studies will have to verify if the mild changes determined in this study will translate to potential contraindications for dental implant placements.
OBJECTIVES: With the higher risk of dental implant failure with type 2 diabetes mellitus (T2DM), there is a need to characterize the jaw bones in those individuals. The aim of this post mortem study was to compare jaw bone quality of individuals with T2DM to healthy controls. MATERIAL AND METHODS: Bone cores from the edentulous lower first molar region and the region of mandibular angle were collected from male individuals with T2DM (n = 10, 70.6 ± 4.5 years) and healthy controls (n = 11, 71.5 ± 3.8 years) during autopsy. Within the T2DM, a subgroup treated with oral antidiabetics (OAD) and one on insulin were identified. Bone quality assessment encompassed evaluation of bone microstructure, matrix composition, and cellular activity, using microcomputed tomography (micro-CT), quantitative backscattered electron imaging (qBEI), Raman spectroscopy, and bone histomorphometry. RESULTS: In the mandibular angle, T2DM showed 51% lower porosity of the lingual cortex (p = 0.004) and 21% higher trabecular thickness (p = 0.008) compared to control. More highly mineralized bone packets were found in the buccal cortex of the mandibular angle in insulin-treated compared to OAD-treated T2DM group (p = 0.034). In the molar region, we found higher heterogeneity of trabecular calcium content in T2DM insulin compared to controls (p = 0.015) and T2DM OAD (p = 0.019). T2DM was associated with lower osteocyte lacunar size in the trabecular bone of the molar region (vs. control p = 0.03). CONCLUSIONS: Alterations in microstructure, mineralization, and osteocyte morphology were determined in jaw bone of individuals with T2DM compared to controls. CLINICAL RELEVANCE: Future studies will have to verify if the mild changes determined in this study will translate to potential contraindications for dental implant placements.
Authors: F Marchand; A Raskin; A Dionnes-Hornes; T Barry; N Dubois; R Valéro; B Vialettes Journal: Diabetes Metab Date: 2012-01-27 Impact factor: 6.041
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Authors: L Castellanos-Cosano; A Rodriguez-Perez; S Spinato; M Wainwright; G Machuca-Portillo; M-A Serrera-Figallo; D Torres-Lagares Journal: Med Oral Patol Oral Cir Bucal Date: 2019-11-01