Brook E Harmon1, Michael D Wirth2, Carol J Boushey3, Lynne R Wilkens3, Emma Draluck4, Nitin Shivappa2, Susan E Steck2, Lorne Hofseth5, Christopher A Haiman6, Loic Le Marchand3, James R Hébert2. 1. School of Public Health, University of Memphis, Memphis, TN; bharmon1@memphis.edu. 2. Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC. 3. University of Hawaii Cancer Center, Honolulu, HI. 4. School of Public Health, University of Memphis, Memphis, TN. 5. South Carolina College of Pharmacy, University of South Carolina, Columbia, SC; and. 6. Cancer Center, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Abstract
Background: Diet is known to influence systemic inflammation, a recognized risk factor for colorectal cancer (CRC). Studies in ethnically diverse populations that examine the association between dietary inflammatory potential and CRC incidence are limited. Objectives: We used the Dietary Inflammatory Index to clarify the relation between the inflammatory potential of diet and CRC incidence across racial/ethnic groups. We hypothesized that proinflammatory diets would be associated with an increased risk of CRC, and that these associations may differ across racial/ethnic groups. Methods: The Multiethnic Cohort (MEC) follows a prospective study design. It includes 190,963 white, African-American, native Hawaiian, Japanese-American, and Latino men and women aged 45-75 y at recruitment and followed over 20 y. Participants completed a food frequency questionnaire from which energy-adjusted Dietary Inflammatory Index (E-DII) scores were computed and categorized into quartiles. CRC incidence was documented through linkage to cancer registry programs. Cox proportional hazards regression was used to estimate HRs and 95% CIs, adjusting for known or expected CRC risk factors. Results: Among all participants, more-proinflammatory diets (highest quartile compared with lowest quartile) were associated with an increased risk of CRC (HR: 1.21; 95% CI: 1.11, 1.32). However, the effect size was larger for men (HR: 1.28; 95% CI: 1.13, 1.45) than for women (HR: 1.16; 95% CI: 1.02, 1.33), although the interaction term for sex was not statistically significant (P-interaction = 0.17). When stratified by race/ethnicity, the association was significantly different between groups for men (P-interaction = 0.01), although not for women (P-interaction = 0.20). Significant associations with HRs ranging from 2.33 to 1.04 were observed in white, Japanese-American, and Latino men, and native Hawaiian women.Conclusions: Overall, more-proinflammatory diets, as identified by the E-DII, were associated with increased CRC risk in MEC participants across racial/ethnic groups. This study adds to the evidence suggesting that diets with high proinflammatory potential may increase CRC risk.
Background: Diet is known to influence systemic inflammation, a recognized risk factor for colorectal cancer (CRC). Studies in ethnically diverse populations that examine the association between dietary inflammatory potential and CRC incidence are limited. Objectives: We used the Dietary Inflammatory Index to clarify the relation between the inflammatory potential of diet and CRC incidence across racial/ethnic groups. We hypothesized that proinflammatory diets would be associated with an increased risk of CRC, and that these associations may differ across racial/ethnic groups. Methods: The Multiethnic Cohort (MEC) follows a prospective study design. It includes 190,963 white, African-American, native Hawaiian, Japanese-American, and Latino men and women aged 45-75 y at recruitment and followed over 20 y. Participants completed a food frequency questionnaire from which energy-adjusted Dietary Inflammatory Index (E-DII) scores were computed and categorized into quartiles. CRC incidence was documented through linkage to cancer registry programs. Cox proportional hazards regression was used to estimate HRs and 95% CIs, adjusting for known or expected CRC risk factors. Results: Among all participants, more-proinflammatory diets (highest quartile compared with lowest quartile) were associated with an increased risk of CRC (HR: 1.21; 95% CI: 1.11, 1.32). However, the effect size was larger for men (HR: 1.28; 95% CI: 1.13, 1.45) than for women (HR: 1.16; 95% CI: 1.02, 1.33), although the interaction term for sex was not statistically significant (P-interaction = 0.17). When stratified by race/ethnicity, the association was significantly different between groups for men (P-interaction = 0.01), although not for women (P-interaction = 0.20). Significant associations with HRs ranging from 2.33 to 1.04 were observed in white, Japanese-American, and Latino men, and native Hawaiian women.Conclusions: Overall, more-proinflammatory diets, as identified by the E-DII, were associated with increased CRC risk in MEC participants across racial/ethnic groups. This study adds to the evidence suggesting that diets with high proinflammatory potential may increase CRC risk.
Authors: Nitin Shivappa; Anna E Prizment; Cindy K Blair; David R Jacobs; Susan E Steck; James R Hébert Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-08-25 Impact factor: 4.254
Authors: Fred K Tabung; Susan E Steck; Jiajia Zhang; Yunsheng Ma; Angela D Liese; Ilir Agalliu; Melanie Hingle; Lifang Hou; Thomas G Hurley; Li Jiao; Lisa W Martin; Amy E Millen; Hannah L Park; Milagros C Rosal; James M Shikany; Nitin Shivappa; Judith K Ockene; James R Hebert Journal: Ann Epidemiol Date: 2015-03-19 Impact factor: 3.797
Authors: Nitin Shivappa; James R Hébert; Ernst R Rietzschel; Marc L De Buyzere; Michel Langlois; Evi Debruyne; Ascensión Marcos; Inge Huybrechts Journal: Br J Nutr Date: 2015-02-02 Impact factor: 3.718
Authors: Alexis Sokol; Michael D Wirth; Marta Manczuk; Nitin Shivappa; Katarzyna Zatonska; Thomas G Hurley; James R Hébert Journal: Nutr Res Date: 2016-04-19 Impact factor: 3.315
Authors: D O Stram; J H Hankin; L R Wilkens; M C Pike; K R Monroe; S Park; B E Henderson; A M Nomura; M E Earle; F S Nagamine; L N Kolonel Journal: Am J Epidemiol Date: 2000-02-15 Impact factor: 4.897
Authors: Nitin Shivappa; Antonella Zucchetto; Maurizio Montella; Diego Serraino; Susan E Steck; Carlo La Vecchia; James R Hébert Journal: Br J Nutr Date: 2015-06-08 Impact factor: 3.718
Authors: Nitin Shivappa; Susan E Steck; Thomas G Hurley; James R Hussey; Yunsheng Ma; Ira S Ockene; Fred Tabung; James R Hébert Journal: Public Health Nutr Date: 2013-10-10 Impact factor: 4.022
Authors: Daria M McMahon; James B Burch; James R Hébert; James W Hardin; Jiajia Zhang; Michael D Wirth; Shawn D Youngstedt; Nitin Shivappa; Steven J Jacobsen; Bette Caan; Stephen K Van Den Eeden Journal: Ann Epidemiol Date: 2018-11-02 Impact factor: 3.797
Authors: Samuel O Antwi; William R Bamlet; Katrina S Pedersen; Kari G Chaffee; Harvey A Risch; Nitin Shivappa; Susan E Steck; Kristin E Anderson; Paige M Bracci; Jerry Polesel; Diego Serraino; Carlo La Vecchia; Cristina Bosetti; Donghui Li; Ann L Oberg; Alan A Arslan; Demetrius Albanes; Eric J Duell; Inge Huybrechts; Laufey T Amundadottir; Robert Hoover; Satu Mannisto; Stephen J Chanock; Wei Zheng; Xiao-Ou Shu; Magdalena Stepien; Federico Canzian; Bas Bueno-de-Mesquita; José Ramon Quirós; Anne Zeleniuch-Jacquotte; Fiona Bruinsma; Roger L Milne; Graham G Giles; James R Hébert; Rachael Z Stolzenberg-Solomon; Gloria M Petersen Journal: Carcinogenesis Date: 2018-07-30 Impact factor: 4.944
Authors: Gabrielle M Turner-McGrievy; Michael D Wirth; Nitin Shivappa; Caroline G Dunn; Anthony Crimarco; Thomas G Hurley; Delia S West; James R Hussey; James R Hébert Journal: Clin Nutr ESPEN Date: 2019-03-01
Authors: Michael D Wirth; Maria Sevoyan; Lorne Hofseth; Nitin Shivappa; Thomas G Hurley; James R Hébert Journal: Brain Behav Immun Date: 2017-12-05 Impact factor: 7.217