Literature DB >> 28178566

WNK Kinase Signaling in Ion Homeostasis and Human Disease.

Masoud Shekarabi1, Jinwei Zhang2, Arjun R Khanna3, David H Ellison4, Eric Delpire5, Kristopher T Kahle6.   

Abstract

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  GABA; KCC2; KCC3; NCC; NKCC1; WNK1; WNK3; WNK4; chloride; homeostasis; kidney

Mesh：

Substances：

Year:  2017        PMID： 28178566     DOI： 10.1016/j.cmet.2017.01.007

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  66 in total

1.  Genetic and pharmacological inactivation of apical Na+-K+-2Cl- cotransporter 1 in choroid plexus epithelial cells reveals the physiological function of the cotransporter.

Authors:  Jeannine M C Gregoriades; Aaron Madaris; Francisco J Alvarez; Francisco J Alvarez-Leefmans
Journal:  Am J Physiol Cell Physiol       Date:  2018-12-21       Impact factor: 4.249

Review 2.  "I don't get no respect": the role of chloride in acute kidney injury.

Authors:  Joshua L Rein; Steven G Coca
Journal:  Am J Physiol Renal Physiol       Date:  2018-12-12

3.  Regulation of erythrocyte Na+/K+/2Cl- cotransport by an oxygen-switched kinase cascade.

Authors:  Suilan Zheng; Nathan A Krump; Mary M McKenna; Yen-Hsing Li; Anke Hannemann; Lisa J Garrett; John S Gibson; David M Bodine; Philip S Low
Journal:  J Biol Chem       Date:  2018-12-18       Impact factor: 5.157

4.  Nephron Remodeling Underlies Hyperkalemia in Familial Hyperkalemic Hypertension.

Authors:  James A McCormick; David H Ellison
Journal:  J Am Soc Nephrol       Date:  2017-07-13       Impact factor: 10.121

5.  Pleiotropic Action of Novel Bruton's Tyrosine Kinase Inhibitor BGB-3111 in Mantle Cell Lymphoma.

Authors:  Carrie J Li; Changying Jiang; Yang Liu; Taylor Bell; Wencai Ma; Yin Ye; Shengjian Huang; Hui Guo; Hui Zhang; Lai Wang; Jing Wang; Krystle Nomie; Liang Zhang; Michael Wang
Journal:  Mol Cancer Ther       Date:  2018-11-09       Impact factor: 6.261

6.  Sodium Valproate Ameliorates Neuronal Apoptosis in a Kainic Acid Model of Epilepsy via Enhancing PKC-Dependent GABAAR γ2 Serine 327 Phosphorylation.

Authors:  Qin Li; Qiu-Qi Li; Ji-Ning Jia; Shan Cao; Zhi-Bin Wang; Xu Wang; Chao Luo; Hong-Hao Zhou; Zhao-Qian Liu; Xiao-Yuan Mao
Journal:  Neurochem Res       Date:  2018-10-11       Impact factor: 3.996

Review 7.  Cl- as a bona fide signaling ion.

Authors:  Benjamin P Lüscher; Laura Vachel; Ehud Ohana; Shmuel Muallem
Journal:  Am J Physiol Cell Physiol       Date:  2019-11-06       Impact factor: 4.249

8.  Analyses of epithelial Na+ channel variants reveal that an extracellular β-ball domain critically regulates ENaC gating.

Authors:  Xueqi Wang; Jingxin Chen; Shujie Shi; Shaohu Sheng; Thomas R Kleyman
Journal:  J Biol Chem       Date:  2019-09-24       Impact factor: 5.157

Review 9.  CRAC channels in secretory epithelial cell function and disease.

Authors:  Haiping Liu; Ahmed Kabrah; Malini Ahuja; Shmuel Muallem
Journal:  Cell Calcium       Date:  2018-12-31       Impact factor: 6.817

10.  Sympathetic Regulation of the NCC (Sodium Chloride Cotransporter) in Dahl Salt-Sensitive Hypertension.

Authors:  Franco Puleo; Kiyoung Kim; Alissa A Frame; Kathryn R Walsh; Mohammed Z Ferdaus; Jesse D Moreira; Erica Comsti; Elizabeth Faudoa; Kayla M Nist; Eric Abkin; Richard D Wainford
Journal:  Hypertension       Date:  2020-09-28       Impact factor: 10.190
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