Neetu Beniwal1, Gaurav Ameta2, Chandra Kumar Chahar3. 1. Department of Pediatrics, Geetanjali Medical College, Udaipur, Rajasthan, 313002, India. neetu.beni@gmail.com. 2. Department of Pediatrics, Geetanjali Medical College, Udaipur, Rajasthan, 313002, India. 3. Department of Pediatrics, S P Medical College, Bikaner, Rajasthan, India.
Abstract
OBJECTIVES: To evaluate the prevalence and clinical features of Celiac disease among children with severe acute malnutrition (SAM). METHODS: This prospective observational study was conducted in PBM Children Hospital, Bikaner from July 2012 through December 2013. All consecutively admitted children with SAM were recruited. All subjects were screened for Celiac disease by serological test for IgA-anti tissue Transglutaminase (IgA tTG) antibodies. All seropositive children underwent upper gastrointestinal endoscopy for small bowel biopsy for the confirmation. Clinical features of patients with and without celiac disease were compared. RESULTS: The sero-prevalence (IgA tTg positivity) of Celiac disease was found to be 15.38% while prevalence of biopsy confirmed Celiac disease was 14.42% among SAM children. Abdominal distension, diarrhea, anorexia, constipation, pain in abdomen, vitamin deficiencies, edema, clubbing and mouth ulcers were more common in patients of Celiac disease compared to patients without Celiac disease but the difference was statistically significant only for abdominal distension and pain abdomen. CONCLUSIONS: There is a high prevalence of Celiac disease in SAM. Screening for Celiac disease (especially in presence of pain abdomen and abdominal distension) should be an essential part of work-up in all children with SAM.
OBJECTIVES: To evaluate the prevalence and clinical features of Celiac disease among children with severe acute malnutrition (SAM). METHODS: This prospective observational study was conducted in PBM Children Hospital, Bikaner from July 2012 through December 2013. All consecutively admitted children with SAM were recruited. All subjects were screened for Celiac disease by serological test for IgA-anti tissue Transglutaminase (IgA tTG) antibodies. All seropositive children underwent upper gastrointestinal endoscopy for small bowel biopsy for the confirmation. Clinical features of patients with and without celiac disease were compared. RESULTS: The sero-prevalence (IgA tTg positivity) of Celiac disease was found to be 15.38% while prevalence of biopsy confirmed Celiac disease was 14.42% among SAM children. Abdominal distension, diarrhea, anorexia, constipation, pain in abdomen, vitamin deficiencies, edema, clubbing and mouth ulcers were more common in patients of Celiac disease compared to patients without Celiac disease but the difference was statistically significant only for abdominal distension and pain abdomen. CONCLUSIONS: There is a high prevalence of Celiac disease in SAM. Screening for Celiac disease (especially in presence of pain abdomen and abdominal distension) should be an essential part of work-up in all children with SAM.
Authors: Jill M Norris; Katherine Barriga; Georgeanna Klingensmith; Michelle Hoffman; George S Eisenbarth; Henry A Erlich; Marian Rewers Journal: JAMA Date: 2003-10-01 Impact factor: 56.272
Authors: Md Amran Gazi; Subhasish Das; Mustafa Mahfuz; Md Mehedi Hasan; Md Shabab Hossain; Shah Mohammad Fahim; Md Ashraful Alam; Zannatun Noor; Carol A Gilchrist; William A Petri; M Masudur Rahman; Ramendra Nath Mazumder; Rashidul Haque; Shafiqul Alam Sarker; Tahmeed Ahmed Journal: BMJ Open Gastroenterol Date: 2019-04-20