Ian N Glaspole1,2, Sally A Chapman3, Wendy A Cooper4,5,6, Samantha J Ellis7, Nicole S Goh1,8, Peter M Hopkins9, Sacha Macansh10, Annabelle Mahar4,5, Yuben P Moodley11, Eldho Paul12,13, Paul N Reynolds3, E Haydn Walters14, Christopher J Zappala15, Tamera J Corte16,17. 1. Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia. 2. Department of Medicine, Monash University, Melbourne, Victoria, Australia. 3. Department of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia. 4. Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. 5. Department of Pathology, University of Sydney, Sydney, New South Wales, Australia. 6. School of Medicine, University of Western Sydney, Sydney, New South Wales, Australia. 7. Department of Radiology, The Alfred Hospital, Melbourne, Victoria, Australia. 8. Institute of Breathing and Sleep, Austin Hospital, Melbourne, Victoria, Australia. 9. Department of Thoracic Medicine, Prince Charles Hospital, Brisbane, Queensland, Australia. 10. Australian IPF Registry, Lung Foundation of Australia, Brisbane, Queensland, Australia. 11. Department of Respiratory Medicine, Fiona Stanley Hospital, Perth, Western Australia, Australia. 12. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. 13. Clinical Haematology Department, The Alfred Hospital, Melbourne, Victoria, Australia. 14. NHMRC CRE for Chronic Respiratory Disease, University of Tasmania, Hobart, Tasmania, Australia. 15. Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia. 16. Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. 17. Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Abstract
BACKGROUND AND OBJECTIVE: Studies analysing the effect of worsening pulmonary physiological impairment in idiopathic pulmonary fibrosis (IPF) with respect to quality of life have been limited to single centres or highly selected trial populations. The aim of this study was to determine the principal determinants of baseline and longitudinal health-related quality of life (HRQoL) in a large unselected IPF population. METHODS: We used the Australian IPF Registry to examine the relationship between HRQoL, measured using the St George Respiratory Questionnaire (SGRQ), and demographic features, physiological features, co-morbidities and symptoms. Linear regression analysis was performed to identify predictors of baseline HRQoL, linear mixed model analysis to determine the effect of time and forced vital capacity (FVC) on SGRQ and Cox proportional hazards regression to examine the relationship between HRQoL and all-cause mortality. RESULTS: Baseline data from 516 patients were available (347 males; mean (SD) age: 71.3 ± 8.6 years). Univariate analysis showed significant associations between HRQoL and demographic, clinical and physiological features. However, multivariate analysis demonstrated independent associations only between SGRQ and dyspnoea (University of California San Diego Shortness of Breathlessness Questionnaire (UCSD-SOBQ); R2 = 0.71, P < 0.0001), cough severity (visual analogue scale; R2 = 0.06, P < 0.0001) and depression (Hospital Anxiety and Depression Scale; R2 = 0.04, P < 0.0001). Linear mixed-effects modelling of combined baseline and longitudinal data confirmed these associations, as well as for FVC% predicted (P = 0.005). Multivariate Cox proportionate-proportional hazards regression analysis demonstrated no association between HRQoL and risk of mortality. CONCLUSION: Cough, dyspnoea and depression are major symptomatic determinants of HRQoL in IPF. FVC decline is associated with worsening HRQoL.
BACKGROUND AND OBJECTIVE: Studies analysing the effect of worsening pulmonary physiological impairment in idiopathic pulmonary fibrosis (IPF) with respect to quality of life have been limited to single centres or highly selected trial populations. The aim of this study was to determine the principal determinants of baseline and longitudinal health-related quality of life (HRQoL) in a large unselected IPF population. METHODS: We used the Australian IPF Registry to examine the relationship between HRQoL, measured using the St George Respiratory Questionnaire (SGRQ), and demographic features, physiological features, co-morbidities and symptoms. Linear regression analysis was performed to identify predictors of baseline HRQoL, linear mixed model analysis to determine the effect of time and forced vital capacity (FVC) on SGRQ and Cox proportional hazards regression to examine the relationship between HRQoL and all-cause mortality. RESULTS: Baseline data from 516 patients were available (347 males; mean (SD) age: 71.3 ± 8.6 years). Univariate analysis showed significant associations between HRQoL and demographic, clinical and physiological features. However, multivariate analysis demonstrated independent associations only between SGRQ and dyspnoea (University of California San Diego Shortness of Breathlessness Questionnaire (UCSD-SOBQ); R2 = 0.71, P < 0.0001), cough severity (visual analogue scale; R2 = 0.06, P < 0.0001) and depression (Hospital Anxiety and Depression Scale; R2 = 0.04, P < 0.0001). Linear mixed-effects modelling of combined baseline and longitudinal data confirmed these associations, as well as for FVC% predicted (P = 0.005). Multivariate Cox proportionate-proportional hazards regression analysis demonstrated no association between HRQoL and risk of mortality. CONCLUSION:Cough, dyspnoea and depression are major symptomatic determinants of HRQoL in IPF. FVC decline is associated with worsening HRQoL.
Authors: E Haydn Walters; Andrew J Palmer; Ingrid A Cox; Barbara de Graaff; Hasnat Ahmed; Julie Campbell; Petr Otahal; Tamera J Corte; Ian Glaspole; Yuben Moodley; Nicole Goh; Sacha Macansh Journal: Qual Life Res Date: 2021-05-17 Impact factor: 4.147
Authors: Michael Kreuter; Jeff Swigris; David Pittrow; Silke Geier; Jens Klotsche; Antje Prasse; Hubert Wirtz; Dirk Koschel; Stefan Andreas; Martin Claussen; Christian Grohé; Henrike Wilkens; Lars Hagmeyer; Dirk Skowasch; Joachim F Meyer; Joachim Kirschner; Sven Gläser; Felix J F Herth; Tobias Welte; Claus Neurohr; Martin Schwaiblmair; Matthias Held; Thomas Bahmer; Marion Frankenberger; Jürgen Behr Journal: Respir Res Date: 2017-07-14
Authors: Ye Jin Lee; Sun Mi Choi; Yeon Joo Lee; Young-Jae Cho; Ho Il Yoon; Jae-Ho Lee; Choon-Taek Lee; Jong Sun Park Journal: PLoS One Date: 2017-09-11 Impact factor: 3.240
Authors: Jeffrey J Swigris; Hilary Wilson; Dirk Esser; Craig S Conoscenti; Wibke Stansen; Nancy Kline Leidy; Kevin K Brown Journal: BMJ Open Respir Res Date: 2018-05-18