Literature DB >> 28164711

Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics.

David E Williams1, Doralyn S Dalisay1,2, Jessie Chen3, Elena A Polishchuck3, Brian O Patrick3, Gagandeep Narula4, Mary Ko4, Yossef Av-Gay4, Haoxin Li5, Nathan Magarvey5, Raymond J Andersen1.   

Abstract

The new ansa macrolide antibiotics 1 to 4 have been isolated from cultures of a Micromonospora sp. obtained from a marine sediment. Rifamycins 1 and 2 are the first natural ansa macrolides to have a 3-amino substituent. Sporalactams A (3) and B (4) are comprised of a heterocylic core 5 and a 14-membered ansa bridge that are both unprecedented. Sporalactam B (4) shows selective and potent inhibition of Mycobacterium tuberculosis.

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Year:  2017        PMID： 28164711     DOI： 10.1021/acs.orglett.6b03619

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

Review 1.  The genus Micromonospora as a model microorganism for bioactive natural product discovery.

Authors:  Mohamed S Hifnawy; Mohamed M Fouda; Ahmed M Sayed; Rabab Mohammed; Hossam M Hassan; Sameh F AbouZid; Mostafa E Rateb; Alexander Keller; Martina Adamek; Nadine Ziemert; Usama Ramadan Abdelmohsen
Journal:  RSC Adv       Date:  2020-06-08       Impact factor: 4.036

Review 2.  Antimicrobial compounds from marine actinomycetes.

Authors:  Cong Wang; Yuanyu Lu; Shugeng Cao
Journal:  Arch Pharm Res       Date:  2020-07-20       Impact factor: 4.946

3.  Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207.

Authors:  Siwen Niu; Ting-Ting Zhou; Chun-Lan Xie; Gai-Yun Zhang; Xian-Wen Yang
Journal:  Mar Drugs       Date:  2017-07-19       Impact factor: 5.118

Review 4.  Marine Pharmacology in 2016-2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

Authors:  Alejandro M S Mayer; Aimee J Guerrero; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Fumiaki Nakamura; Nobuhiro Fusetani
Journal:  Mar Drugs       Date:  2021-01-21       Impact factor: 5.118

5.  Insights into the Variation in Bioactivities of Closely Related Streptomyces Strains from Marine Sediments of the Visayan Sea against ESKAPE and Ovarian Cancer.

Authors:  Edna M Sabido; Chuckcris P Tenebro; Dana Joanne Von L Trono; Carmela Vannette B Vicera; Sheeny Fane L Leonida; Jose Jeffrey Wayne B Maybay; Rikka Reyes-Salarda; Diana S Amago; Angelica Marie V Aguadera; May C Octaviano; Jonel P Saludes; Doralyn S Dalisay
Journal:  Mar Drugs       Date:  2021-07-31       Impact factor: 5.118

6.  Bacillamidins A⁻G from a Marine-Derived Bacillus pumilus.

Authors:  Si-Yu Zhou; Yi-Jie Hu; Fan-Cheng Meng; Shen-Yue Qu; Rui Wang; Raymond J Andersen; Zhi-Hua Liao; Min Chen
Journal:  Mar Drugs       Date:  2018-09-11       Impact factor: 5.118
  6 in total

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