Katalin Z Ronai1, Andras Szentkiralyi1,2, Alpar S Lazar1,3, Akos Ujszaszi4, Csilla Turanyi1, Ferenc Gombos5, Istvan Mucsi1,6, Robert Bodizs1,5, Miklos Z Molnar7,8, Marta Novak1,9. 1. Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary. 2. Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany. 3. Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom. 4. Institute of Pathophysiology, Semmelweis University, Budapest, Hungary. 5. Department of General Psychology, Pázmány Péter Catholic University, Budapest, Hungary. 6. Department of Medicine, Division of Nephrology, University Health Network, University of Toronto, Toronto, Canada. 7. Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Tennessee. 8. Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary. 9. Centre for Mental Health, University Health Network and Department of Psychiatry, University of Toronto, Toronto, Canada.
Abstract
STUDY OBJECTIVES: Both depression and sleep complaints are very prevalent among kidney transplant (kTx) recipients. However, details of the complex relationship between sleep and depression in this population are not well documented. Thus, we investigated the association between depressive symptoms and sleep macrostructure parameters among prevalent kTx recipients. METHODS: Ninety-five kTx recipients participated in the study (54 males, mean ± standard devation age 51 ± 13 years, body mass index 26 ± 4 kg/m2, estimated glomerular filtration rate 53 ± 19 ml/min/1.73 m2). Symptoms of depression were assessed by the Center for Epidemiologic Studies - Depression Scale (CES-D). After 1-night polysomnography each recording was visually scored and sleep macrostructure was analyzed. RESULTS: The CES-D score was significantly associated with the amount of stage 2 sleep (r = 0.20, P < .05), rapid eye movement (REM) latency (r = 0.21, P < .05) and REM percentage (r = -0.24, P < .05), but not with the amount of slow wave sleep (r = -0.12, P > .05). In multivariable linear regression models the CES-D score was independently associated with the amount of stage 2 sleep (β: 0.205; confidence interval: 0.001-0.409; P = .05) and REM latency (β: 0.234; confidence interval: 0.001-0.468; P = .05) after adjustment for potential confounders. CONCLUSIONS: Depressive symptoms among kTx recipients are associated with increased amount of stage 2 sleep and prolonged REM latency. Further studies are needed to confirm our findings and understand potential clinical implications.
STUDY OBJECTIVES: Both depression and sleep complaints are very prevalent among kidney transplant (kTx) recipients. However, details of the complex relationship between sleep and depression in this population are not well documented. Thus, we investigated the association between depressive symptoms and sleep macrostructure parameters among prevalent kTx recipients. METHODS: Ninety-five kTx recipients participated in the study (54 males, mean ± standard devation age 51 ± 13 years, body mass index 26 ± 4 kg/m2, estimated glomerular filtration rate 53 ± 19 ml/min/1.73 m2). Symptoms of depression were assessed by the Center for Epidemiologic Studies - Depression Scale (CES-D). After 1-night polysomnography each recording was visually scored and sleep macrostructure was analyzed. RESULTS: The CES-D score was significantly associated with the amount of stage 2 sleep (r = 0.20, P < .05), rapid eye movement (REM) latency (r = 0.21, P < .05) and REM percentage (r = -0.24, P < .05), but not with the amount of slow wave sleep (r = -0.12, P > .05). In multivariable linear regression models the CES-D score was independently associated with the amount of stage 2 sleep (β: 0.205; confidence interval: 0.001-0.409; P = .05) and REM latency (β: 0.234; confidence interval: 0.001-0.468; P = .05) after adjustment for potential confounders. CONCLUSIONS:Depressive symptoms among kTx recipients are associated with increased amount of stage 2 sleep and prolonged REM latency. Further studies are needed to confirm our findings and understand potential clinical implications.
Authors: Suetonia Palmer; Mariacristina Vecchio; Jonathan C Craig; Marcello Tonelli; David W Johnson; Antonio Nicolucci; Fabio Pellegrini; Valeria Saglimbene; Giancarlo Logroscino; Steven Fishbane; Giovanni F M Strippoli Journal: Kidney Int Date: 2013-03-13 Impact factor: 10.612
Authors: Claire Juliet Martin; Elmi Muller; Demetre Labadarios; Frederick Johannes Veldman; Susanna Maria Kassier Journal: Qual Life Res Date: 2021-06-22 Impact factor: 4.147
Authors: Minxuan Huang; Donald L Bliwise; Martica H Hall; Dayna A Johnson; Richard P Sloan; Amit Shah; Jack Goldberg; Yi-An Ko; Nancy Murrah; Oleksiy M Levantsevych; Lucy Shallenberger; Rami Abdulbagki; J Douglas Bremner; Viola Vaccarino Journal: Ann Behav Med Date: 2022-03-01