S T Gray1,2, L P Hoehle1,2, K M Phillips1,2, D S Caradonna1,3, A R Sedaghat1,2,3,4. 1. Department of Otolaryngology, Harvard Medical School, Boston, MA, USA. 2. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. 3. Division of Otolaryngology, Beth Israel Deaconess Medical Center, Boston, MA, USA. 4. Department of Otolaryngology and Communications Enhancement, Boston Children's Hospital, Boston, MA, USA.
Abstract
OBJECTIVE: In chronic rhinosinusitis (CRS), although patient-reported severity of sinonasal symptoms is significantly associated with diminishment of patients' general health-related quality of life (QOL), it remains unclear whether patient-perceived control of CRS symptomatology is associated with patients' QOL. In this study, we sought to determine the association between patient-perceived control of CRS symptomatology and QOL. DESIGN: Prospective cross-sectional study. SETTING: Academic, tertiary care centre. PARTICIPANTS: A cohort of 166 adults with CRS who were asked to categorise their level of CRS symptom control as "Not at all," "A little," "Somewhat," "Very" and "Completely." MAIN OUTCOME MEASURE: General health-related QOL, as reflected by the five-dimensional EuroQol quality of life survey-derived visual analogue scale (EQ5D-VAS) and health utility values (EQ5D-HUV). RESULTS: We found that higher EQ5D-VAS scores were associated with CRS patients who classified their symptom control as "Very" (adjusted β=15.74, 95% CI: 5.44 to 26.04, P=.003) and "Completely" (adjusted β=14.24, 95% CI: 2.98 to 25.52, P=.014) compared to patients who classified their symptom control as "Not at all." This was also true for higher EQ5D-HUV which was associated with patient-reported CRS symptom control of "A little" (adjusted β=0.10, 95% CI: 0.01 to 0.18, P=.024), "Somewhat" (adjusted β=0.08, 95% CI: 0.00 to 0.17, P=.049), "Very" (adjusted β=0.13, 95% CI: 0.05 to 0.21, P=.002) and "Completely" (adjusted β=0.18, 95% CI: 0.09 to 0.27, P<.001). CONCLUSIONS: Higher levels of patient-reported CRS symptom control are therefore associated with better QOL. These findings suggest that CRS symptom control should be targeted for improving patients' QOL.
OBJECTIVE: In chronic rhinosinusitis (CRS), although patient-reported severity of sinonasal symptoms is significantly associated with diminishment of patients' general health-related quality of life (QOL), it remains unclear whether patient-perceived control of CRS symptomatology is associated with patients' QOL. In this study, we sought to determine the association between patient-perceived control of CRS symptomatology and QOL. DESIGN: Prospective cross-sectional study. SETTING: Academic, tertiary care centre. PARTICIPANTS: A cohort of 166 adults with CRS who were asked to categorise their level of CRS symptom control as "Not at all," "A little," "Somewhat," "Very" and "Completely." MAIN OUTCOME MEASURE: General health-related QOL, as reflected by the five-dimensional EuroQol quality of life survey-derived visual analogue scale (EQ5D-VAS) and health utility values (EQ5D-HUV). RESULTS: We found that higher EQ5D-VAS scores were associated with CRSpatients who classified their symptom control as "Very" (adjusted β=15.74, 95% CI: 5.44 to 26.04, P=.003) and "Completely" (adjusted β=14.24, 95% CI: 2.98 to 25.52, P=.014) compared to patients who classified their symptom control as "Not at all." This was also true for higher EQ5D-HUV which was associated with patient-reported CRS symptom control of "A little" (adjusted β=0.10, 95% CI: 0.01 to 0.18, P=.024), "Somewhat" (adjusted β=0.08, 95% CI: 0.00 to 0.17, P=.049), "Very" (adjusted β=0.13, 95% CI: 0.05 to 0.21, P=.002) and "Completely" (adjusted β=0.18, 95% CI: 0.09 to 0.27, P<.001). CONCLUSIONS: Higher levels of patient-reported CRS symptom control are therefore associated with better QOL. These findings suggest that CRS symptom control should be targeted for improving patients' QOL.