PURPOSE: To investigate age-related changes in T1 relaxation time in deep gray matter structures in healthy volunteers using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE). MATERIALS AND METHODS: In all, 70 healthy volunteers (aged 20-76, mean age 42.6 years) were scanned at 3T magnetic resonance imaging (MRI). A MP2RAGE sequence was employed to quantify T1 relaxation times. After the spatial normalization of T1 maps with the diffeomorphic anatomical registration using the exponentiated Lie algebra algorithm, voxel-based regression analysis was conducted. In addition, linear and quadratic regression analyses of regions of interest (ROIs) were also performed. RESULTS: With aging, voxel-based analysis (VBA) revealed significant T1 value decreases in the ventral-inferior putamen, nucleus accumbens, and amygdala, whereas T1 values significantly increased in the thalamus and white matter as well (P < 0.05 at cluster level, false discovery rate). ROI analysis revealed that T1 values in the nucleus accumbens linearly decreased with aging (P = 0.0016), supporting the VBA result. T1 values in the thalamus (P < 0.0001), substantia nigra (P = 0.0003), and globus pallidus (P < 0.0001) had a best fit to quadratic curves, with the minimum T1 values observed between 30 and 50 years of age. CONCLUSION: Age-related changes in T1 relaxation time vary by location in deep gray matter. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:724-731.
PURPOSE: To investigate age-related changes in T1 relaxation time in deep gray matter structures in healthy volunteers using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE). MATERIALS AND METHODS: In all, 70 healthy volunteers (aged 20-76, mean age 42.6 years) were scanned at 3T magnetic resonance imaging (MRI). A MP2RAGE sequence was employed to quantify T1 relaxation times. After the spatial normalization of T1 maps with the diffeomorphic anatomical registration using the exponentiated Lie algebra algorithm, voxel-based regression analysis was conducted. In addition, linear and quadratic regression analyses of regions of interest (ROIs) were also performed. RESULTS: With aging, voxel-based analysis (VBA) revealed significant T1 value decreases in the ventral-inferior putamen, nucleus accumbens, and amygdala, whereas T1 values significantly increased in the thalamus and white matter as well (P < 0.05 at cluster level, false discovery rate). ROI analysis revealed that T1 values in the nucleus accumbens linearly decreased with aging (P = 0.0016), supporting the VBA result. T1 values in the thalamus (P < 0.0001), substantia nigra (P = 0.0003), and globus pallidus (P < 0.0001) had a best fit to quadratic curves, with the minimum T1 values observed between 30 and 50 years of age. CONCLUSION: Age-related changes in T1 relaxation time vary by location in deep gray matter. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:724-731.
Authors: Mustapha Bouhrara; Abinand C Rejimon; Luis E Cortina; Nikkita Khattar; Christopher M Bergeron; Luigi Ferrucci; Susan M Resnick; Richard G Spencer Journal: Neurobiol Aging Date: 2019-10-14 Impact factor: 4.673
Authors: Luis E Cortina; Richard W Kim; Matthew Kiely; Curtis Triebswetter; Zhaoyuan Gong; Maryam H Alsameen; Mustapha Bouhrara Journal: Magn Reson Imaging Date: 2021-10-19 Impact factor: 2.546
Authors: Mustapha Bouhrara; Joseph S R Alisch; Nikkita Khattar; Richard W Kim; Abinand C Rejimon; Luis E Cortina; Wenshu Qian; Luigi Ferrucci; Susan M Resnick; Richard G Spencer Journal: BMJ Neurol Open Date: 2020-07-01
Authors: Sen Ma; Nan Wang; Zhaoyang Fan; Marwa Kaisey; Nancy L Sicotte; Anthony G Christodoulou; Debiao Li Journal: Magn Reson Med Date: 2020-10-26 Impact factor: 4.668
Authors: Nikkita Khattar; Curtis Triebswetter; Matthew Kiely; Luigi Ferrucci; Susan M Resnick; Richard G Spencer; Mustapha Bouhrara Journal: Neuroimage Date: 2021-06-15 Impact factor: 7.400
Authors: Nikos Priovoulos; Stan C J van Boxel; Heidi I L Jacobs; Benedikt A Poser; Kamil Uludag; Frans R J Verhey; Dimo Ivanov Journal: Brain Struct Funct Date: 2020-10-22 Impact factor: 3.270