Xingchen Wu1,2, Abhisek Bhattarai3,4, Pasi Korkola5, Hannu Pertovaara6, Hannu Eskola3,4, Pirkko-Liisa Kellokumpu-Lehtinen6,7. 1. Department of Oncology, Tampere University Hospital, Tampere, Finland. Xingchen.Wu@uta.fi. 2. Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Xingchen.Wu@uta.fi. 3. Medical Imaging Centre, Department of Radiology, Tampere University Hospital, Tampere, Finland. 4. Faculty of Biomedical Engineering, Tampere University of Technology, Tampere, Finland. 5. Medical Imaging Centre, Department of Nuclear Medicine, Tampere University Hospital, Tampere, Finland. 6. Department of Oncology, Tampere University Hospital, Tampere, Finland. 7. Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Abstract
PURPOSE: The aim of this study was to explore the association between liver, mediastinum and tumor 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake during chemotherapy in diffuse large B cell lymphoma (DLBCL). PROCEDURES: Nineteen patients with proven DLBCL underwent positron emission tomography (PET)/X-ray computed tomography scan at baseline, 1 week and 2 cycles after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) therapy, and again after chemotherapy completion. The mean and maximal standardized uptake value (SUVmean and SUVmax) of the liver and mediastinum were measured and correlated with the tumor SUVmax, SUVsum, whole-body metabolic tumor volume (MTVwb), and total lesion glycolysis (TLG). RESULTS: At baseline, both the liver and mediastinum SUVmean and SUVmax correlated inversely with the tumor MTVwb or TLG (p < 0.01 or 0.001). The liver SUVmean and SUVmax increased significantly after 1 week of R-CHOP therapy and remained at the high level until chemotherapy completion. The mediastinum SUVmean and SUVmax remained stable during chemotherapy. The tumor SUVmax, SUVsum, MTVwb, and TLG decreased significantly after 1 week of R-CHOP therapy. The change of the liver SUVmean correlated inversely with the change of tumor MTVwb and TLG after 1 week of chemotherapy (p < 0.05, respectively). The intersubject variability of liver and mediastinum [18F]FDG uptake ranged from 11 to 26 %. CONCLUSIONS: The liver [18F]FDG uptake increased significantly after R-CHOP therapy. One of the possible reasons is the distribution of a greater fraction of the tracer to healthy tissues rather than tumor after effective chemotherapy. The variability of the liver [18F]FDG uptake during chemotherapy might affect the visual analysis of the interim PET scan and this needs to be confirmed in future studies with a large patient cohort. In addition, the intersubject variability of the liver and mediastinum [18F]FDG uptake should be considered.
PURPOSE: The aim of this study was to explore the association between liver, mediastinum and tumor2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake during chemotherapy in diffuse large B cell lymphoma (DLBCL). PROCEDURES: Nineteen patients with proven DLBCL underwent positron emission tomography (PET)/X-ray computed tomography scan at baseline, 1 week and 2 cycles after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) therapy, and again after chemotherapy completion. The mean and maximal standardized uptake value (SUVmean and SUVmax) of the liver and mediastinum were measured and correlated with the tumor SUVmax, SUVsum, whole-body metabolic tumor volume (MTVwb), and total lesion glycolysis (TLG). RESULTS: At baseline, both the liver and mediastinum SUVmean and SUVmax correlated inversely with the tumor MTVwb or TLG (p < 0.01 or 0.001). The liver SUVmean and SUVmax increased significantly after 1 week of R-CHOP therapy and remained at the high level until chemotherapy completion. The mediastinum SUVmean and SUVmax remained stable during chemotherapy. The tumor SUVmax, SUVsum, MTVwb, and TLG decreased significantly after 1 week of R-CHOP therapy. The change of the liver SUVmean correlated inversely with the change of tumor MTVwb and TLG after 1 week of chemotherapy (p < 0.05, respectively). The intersubject variability of liver and mediastinum [18F]FDG uptake ranged from 11 to 26 %. CONCLUSIONS: The liver [18F]FDG uptake increased significantly after R-CHOP therapy. One of the possible reasons is the distribution of a greater fraction of the tracer to healthy tissues rather than tumor after effective chemotherapy. The variability of the liver [18F]FDG uptake during chemotherapy might affect the visual analysis of the interim PET scan and this needs to be confirmed in future studies with a large patient cohort. In addition, the intersubject variability of the liver and mediastinum [18F]FDG uptake should be considered.
Authors: Sally F Barrington; Wendi Qian; Edward J Somer; Antonella Franceschetto; Bruno Bagni; Eva Brun; Helén Almquist; Annika Loft; Liselotte Højgaard; Massimo Federico; Andrea Gallamini; Paul Smith; Peter Johnson; John Radford; Michael J O'Doherty Journal: Eur J Nucl Med Mol Imaging Date: 2010-05-27 Impact factor: 9.236
Authors: Agostino Chiaravalloti; Roberta Danieli; Paolo Abbatiello; Barbara Di Pietro; Laura Travascio; Maria Cantonetti; Manlio Guazzaroni; Antonio Orlacchio; Giovanni Simonetti; Orazio Schillaci Journal: Eur J Nucl Med Mol Imaging Date: 2014-02-22 Impact factor: 9.236
Authors: Bruce D Cheson; Beate Pfistner; Malik E Juweid; Randy D Gascoyne; Lena Specht; Sandra J Horning; Bertrand Coiffier; Richard I Fisher; Anton Hagenbeek; Emanuele Zucca; Steven T Rosen; Sigrid Stroobants; T Andrew Lister; Richard T Hoppe; Martin Dreyling; Kensei Tobinai; Julie M Vose; Joseph M Connors; Massimo Federico; Volker Diehl Journal: J Clin Oncol Date: 2007-01-22 Impact factor: 44.544
Authors: Raef R Boktor; Gregory Walker; Roderick Stacey; Samuel Gledhill; Alexander G Pitman Journal: J Nucl Med Date: 2013-03-19 Impact factor: 10.057
Authors: Marius E Mayerhoefer; Anton Staudenherz; Barbara Kiesewetter; Michael Weber; Ingrid Simonitsch-Klupp; Peter Gibbs; Werner Dolak; Julius Lukas; Markus Raderer Journal: Mol Imaging Biol Date: 2019-12 Impact factor: 3.488
Authors: Gerben J C Zwezerijnen; Jakoba J Eertink; Maria C Ferrández; Sanne E Wiegers; Coreline N Burggraaff; Pieternella J Lugtenburg; Martijn W Heymans; Henrica C W de Vet; Josée M Zijlstra; Ronald Boellaard Journal: Eur J Nucl Med Mol Imaging Date: 2022-09-27 Impact factor: 10.057
Authors: Hajira Ilyas; N George Mikhaeel; Joel T Dunn; Fareen Rahman; Henrik Møller; Daniel Smith; Sally F Barrington Journal: Eur J Nucl Med Mol Imaging Date: 2018-02-19 Impact factor: 9.236
Authors: Afnan A Malaih; Joel T Dunn; Lotte Nygård; David G Kovacs; Flemming L Andersen; Sally F Barrington; Barbara M Fischer Journal: Nucl Med Commun Date: 2022-05-01 Impact factor: 1.698
Authors: Mayara L C Dourado; Luca T Dompieri; Glauber M Leitão; Felipe A Mourato; Renata G G Santos; Paulo J Almeida Filho; Brivaldo Markman Filho; Marcelo D T Melo; Simone C S Brandão Journal: Arq Bras Cardiol Date: 2022-05-02 Impact factor: 2.667