Literature DB >> 28144767

An efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives under catalyst-free conditions.

Yong-Xiang Zheng1, Zhan Xun1, Juan-Juan Zhang1, Zhi-Bin Huang1, Da-Qing Shi2.   

Abstract

A concise, efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives via a three-component reaction of 4-oxo-4H-chromene-3-carbaldehydes, malononitrile or cyanoacetates, and aromatic amines under catalyst-free conditions in an environmentally friendly medium (ethanol-water, 3:1 v/v) is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystallization and chromatographic purification methods.

Entities:  

Keywords:  Chromeno[4,3-b]pyridine; Group-assisted purification (GAP) process; Multicomponent reactions (MCRs)

Mesh：

Substances：

Year:  2017        PMID： 28144767     DOI： 10.1007/s11030-016-9723-6

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  30 in total

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9.  Synthesis, X-ray structure, and pharmacological activity of some 6,6-disubstituted chromeno[4,3-b]- and chromeno- [3,4-c]-quinolines.

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  1 in total

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