Literature DB >> 15967664

Synthesis and biological evaluation of novel angularly fused polycyclic coumarins.

Imtyaz A Khan1, Manohar V Kulkarni, M Gopal, M S Shahabuddin, Chung-Ming Sun.   

Abstract

In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties.

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Year:  2005        PMID： 15967664     DOI： 10.1016/j.bmcl.2005.05.063

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Multicomponent Synthesis of 2,3-Dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: A Novel Heterocyclic Scaffold with Antibacterial Activity.

Authors:  Liliya V Frolova; Indranil Malik; Pavel Y Uglinskii; Snezna Rogelj; Alexander Kornienko; Igor V Magedov
Journal:  Tetrahedron Lett       Date:  2011-12-07       Impact factor: 2.415

2.  An efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives under catalyst-free conditions.

Authors:  Yong-Xiang Zheng; Zhan Xun; Juan-Juan Zhang; Zhi-Bin Huang; Da-Qing Shi
Journal:  Mol Divers       Date:  2017-01-31       Impact factor: 2.943

Review 3.  Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media.

Authors:  Zahra Khademi; Kobra Nikoofar
Journal:  RSC Adv       Date:  2020-08-17       Impact factor: 4.036

4.  Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates.

Authors:  Kalicharan Cattopadhyay; Antonio Recio; Jon A Tunge
Journal:  Org Biomol Chem       Date:  2012-07-25       Impact factor: 3.876

5.  The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells.

Authors:  Tomonori Nakamura; Naoko Kodama; Manabu Oda; Shizuko Tsuchiya; Yu Arai; Takuya Kumamoto; Tsutomu Ishikawa; Koichi Ueno; Shingo Yano
Journal:  J Nat Med       Date:  2008-07-09       Impact factor: 2.343

6.  Novel 9-(alkylthio)-Acenaphtho[1,2-e]-1,2,4-triazine derivatives: synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2).

Authors:  Mohammad K Mohammadi; Omidreza Firuzi; Mehdi Khoshneviszadeh; Nima Razzaghi-Asl; Saghi Sepehri; Ramin Miri
Journal:  Daru       Date:  2014-01-06       Impact factor: 3.117

Review 7.  Benzofuran as a promising scaffold for the synthesis of antimicrobial and antibreast cancer agents: A review.

Authors:  Ghadamali Khodarahmi; Parvin Asadi; Farshid Hassanzadeh; Elham Khodarahmi
Journal:  J Res Med Sci       Date:  2015-11       Impact factor: 1.852
  7 in total

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